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Mortality studies in systemic lupus erythematosus. Results from a single center. III. Improved survival over 24 years.
J Rheumatol 1997; 24(6):1061-5JR

Abstract

OBJECTIVE

Prognosis studies have indicated that survival of patients with systemic lupus erythematosus (SLE) has improved significantly. We investigate whether the apparent improvement in the survival of patients with SLE is associated with a reduction in the risk of death compared with the general population, or with changes over time in the distribution of various prognostic factors.

METHODS

The University of Toronto cohort of 720 patients with SLE followed between 1970 and 1994 was divided into 3 groups based on year of entry into study: Group A 1970-77, Group B 1978-85, Group C 1986-1994. Standardized mortality ratios (SMR) were calculated for each cohort. Prognostic factors for death occurring in the first 8 yr period after entry into the study were examined in each of the 3 cohorts. Analysis involved chi-squared tests for categorical values and unpaired t tests for continuous variables.

RESULTS

Group A comprised 183 patients, Group B 332 patients, and Group C 205 patients. An examination of the first 8 years of evaluation for each group revealed that the SMR decrease over time ranged from 10.1-fold greater than the general population in Group A, to 4.8-fold in Group B, to 3.3-fold in Group C. Prognostic factors for death varied over time, with vasculitis decreasing and hyperlipidemia increasing.

CONCLUSION

Survival in SLE has improved over 24 yrs in the University of Toronto cohort more than the health of the general population has improved. This improved survival was not related to changing demographics, severity of lupus at presentation, major change in disease patterns, or new modalities of treatment.

Authors+Show Affiliations

Centre for Prognostic Studies in the Rheumatic Diseases, University of Toronto, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9195509

Citation

Urowitz, M B., et al. "Mortality Studies in Systemic Lupus Erythematosus. Results From a Single Center. III. Improved Survival Over 24 Years." The Journal of Rheumatology, vol. 24, no. 6, 1997, pp. 1061-5.
Urowitz MB, Gladman DD, Abu-Shakra M, et al. Mortality studies in systemic lupus erythematosus. Results from a single center. III. Improved survival over 24 years. J Rheumatol. 1997;24(6):1061-5.
Urowitz, M. B., Gladman, D. D., Abu-Shakra, M., & Farewell, V. T. (1997). Mortality studies in systemic lupus erythematosus. Results from a single center. III. Improved survival over 24 years. The Journal of Rheumatology, 24(6), pp. 1061-5.
Urowitz MB, et al. Mortality Studies in Systemic Lupus Erythematosus. Results From a Single Center. III. Improved Survival Over 24 Years. J Rheumatol. 1997;24(6):1061-5. PubMed PMID: 9195509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mortality studies in systemic lupus erythematosus. Results from a single center. III. Improved survival over 24 years. AU - Urowitz,M B, AU - Gladman,D D, AU - Abu-Shakra,M, AU - Farewell,V T, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 1061 EP - 5 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 24 IS - 6 N2 - OBJECTIVE: Prognosis studies have indicated that survival of patients with systemic lupus erythematosus (SLE) has improved significantly. We investigate whether the apparent improvement in the survival of patients with SLE is associated with a reduction in the risk of death compared with the general population, or with changes over time in the distribution of various prognostic factors. METHODS: The University of Toronto cohort of 720 patients with SLE followed between 1970 and 1994 was divided into 3 groups based on year of entry into study: Group A 1970-77, Group B 1978-85, Group C 1986-1994. Standardized mortality ratios (SMR) were calculated for each cohort. Prognostic factors for death occurring in the first 8 yr period after entry into the study were examined in each of the 3 cohorts. Analysis involved chi-squared tests for categorical values and unpaired t tests for continuous variables. RESULTS: Group A comprised 183 patients, Group B 332 patients, and Group C 205 patients. An examination of the first 8 years of evaluation for each group revealed that the SMR decrease over time ranged from 10.1-fold greater than the general population in Group A, to 4.8-fold in Group B, to 3.3-fold in Group C. Prognostic factors for death varied over time, with vasculitis decreasing and hyperlipidemia increasing. CONCLUSION: Survival in SLE has improved over 24 yrs in the University of Toronto cohort more than the health of the general population has improved. This improved survival was not related to changing demographics, severity of lupus at presentation, major change in disease patterns, or new modalities of treatment. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/9195509/Mortality_studies_in_systemic_lupus_erythematosus__Results_from_a_single_center__III__Improved_survival_over_24_years_ L2 - http://www.diseaseinfosearch.org/result/9373 DB - PRIME DP - Unbound Medicine ER -