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Posttraining injections of MK-801 produce a time-dependent impairment of memory in two water maze tasks.
Neurobiol Learn Mem. 1997 Jul; 68(1):42-50.NL

Abstract

The role of glutamatergic N-methyl-D-aspartate (NMDA) receptors in memory storage processes was examined using systemic posttraining injections of MK-801. Male Long-Evans rats received an eight-trial (30-s ITI) training session on a spatial or cued water maze task. In the spatial task, a submerged escape platform was located in the same quadrant of the maze on all trials. In the cued task, a visible escape platform was located in a different quadrant of the maze on each trial. Following Trial 8 in both tasks, the rats received a posttraining intraperitoneal injection of the NMDA receptor antagonist MK-801 (0.025, 0.05, 0.1, or 0.2 mg/kg) or saline. On a retention test session 24 h later, latency to mount the escape platform was used as a measure of memory. In both tasks, the retention test escape latencies of animals given MK-801 (0.05 and 0.1 mg/kg) were significantly higher than those of saline-injected controls, indicating a drug-induced impairment of memory. Injections of MK-801 (0.05 mg/kg) did not affect retention when administered 2 h posttraining in either task, indicating that the effects of MK-801 on retention are not due to an influence on non-mnemonic factors. Control experiments indicated that the memory impairing effects of MK-801 were due to an influence on memory for the type of discrimination training given (i.e., spatial or cued) and not due to an influence on a mnemonic strategy common to both tasks. The findings indicate a time-dependent role for NMDA receptor function in memory storage processes.

Authors+Show Affiliations

Department of Psychology, University of New Orleans, LA 70148, USA. mgpps@uno.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9195588

Citation

Packard, M G., and L A. Teather. "Posttraining Injections of MK-801 Produce a Time-dependent Impairment of Memory in Two Water Maze Tasks." Neurobiology of Learning and Memory, vol. 68, no. 1, 1997, pp. 42-50.
Packard MG, Teather LA. Posttraining injections of MK-801 produce a time-dependent impairment of memory in two water maze tasks. Neurobiol Learn Mem. 1997;68(1):42-50.
Packard, M. G., & Teather, L. A. (1997). Posttraining injections of MK-801 produce a time-dependent impairment of memory in two water maze tasks. Neurobiology of Learning and Memory, 68(1), 42-50.
Packard MG, Teather LA. Posttraining Injections of MK-801 Produce a Time-dependent Impairment of Memory in Two Water Maze Tasks. Neurobiol Learn Mem. 1997;68(1):42-50. PubMed PMID: 9195588.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Posttraining injections of MK-801 produce a time-dependent impairment of memory in two water maze tasks. AU - Packard,M G, AU - Teather,L A, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 42 EP - 50 JF - Neurobiology of learning and memory JO - Neurobiol Learn Mem VL - 68 IS - 1 N2 - The role of glutamatergic N-methyl-D-aspartate (NMDA) receptors in memory storage processes was examined using systemic posttraining injections of MK-801. Male Long-Evans rats received an eight-trial (30-s ITI) training session on a spatial or cued water maze task. In the spatial task, a submerged escape platform was located in the same quadrant of the maze on all trials. In the cued task, a visible escape platform was located in a different quadrant of the maze on each trial. Following Trial 8 in both tasks, the rats received a posttraining intraperitoneal injection of the NMDA receptor antagonist MK-801 (0.025, 0.05, 0.1, or 0.2 mg/kg) or saline. On a retention test session 24 h later, latency to mount the escape platform was used as a measure of memory. In both tasks, the retention test escape latencies of animals given MK-801 (0.05 and 0.1 mg/kg) were significantly higher than those of saline-injected controls, indicating a drug-induced impairment of memory. Injections of MK-801 (0.05 mg/kg) did not affect retention when administered 2 h posttraining in either task, indicating that the effects of MK-801 on retention are not due to an influence on non-mnemonic factors. Control experiments indicated that the memory impairing effects of MK-801 were due to an influence on memory for the type of discrimination training given (i.e., spatial or cued) and not due to an influence on a mnemonic strategy common to both tasks. The findings indicate a time-dependent role for NMDA receptor function in memory storage processes. SN - 1074-7427 UR - https://www.unboundmedicine.com/medline/citation/9195588/Posttraining_injections_of_MK_801_produce_a_time_dependent_impairment_of_memory_in_two_water_maze_tasks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1074-7427(96)93762-4 DB - PRIME DP - Unbound Medicine ER -