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Cardiopulmonary manifestations of schistosomiasis.
Semin Respir Infect. 1997 Jun; 12(2):159-70.SR

Abstract

Three major schistosome species infect hundreds of millions of people worldwide. The majority of these infections are asymptomatic, but significant morbidity and mortality can occur as a consequence of ongoing egg deposition in host tissues. Acutely, transient chest radiographic abnormalities and nonspecific influenza-like symptoms can occur, including cough. The most common chronic pathological sequelae of schistosomiasis are those of portal hypertension with Schistosoma mansoni or S. japonicum, and genitourinary tract obstruction with S. haematobium. In less than 5% of infections, schistosomal egg obstruction of the lung vasculature results in pulmonary hypertension and cor pulmonale. Limited data suggests that cardiopulmonary schistosomiasis is seen most often in S. mansoni infections. Hepatic fibrosis and portal hypertension appear to be a prerequisite to the development of schistosomal cor pulmonale caused by this species. The premortem diagnosis of cardiopulmonary schistosomiasis depends on the detection of viable schistosomal ova in stool or urine along with evidence of characteristic hepatic fibrosis and pulmonary hypertension. Although treatment with praziquantel can effectively eradicate all schistosomal infections with minimal toxicity, cardiopulmonary manifestations are not likely to be reversible given the chronic fibrotic tissue changes that are present.

Authors+Show Affiliations

Department of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, USA.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

9195681

Citation

Morris, W, and C M. Knauer. "Cardiopulmonary Manifestations of Schistosomiasis." Seminars in Respiratory Infections, vol. 12, no. 2, 1997, pp. 159-70.
Morris W, Knauer CM. Cardiopulmonary manifestations of schistosomiasis. Semin Respir Infect. 1997;12(2):159-70.
Morris, W., & Knauer, C. M. (1997). Cardiopulmonary manifestations of schistosomiasis. Seminars in Respiratory Infections, 12(2), 159-70.
Morris W, Knauer CM. Cardiopulmonary Manifestations of Schistosomiasis. Semin Respir Infect. 1997;12(2):159-70. PubMed PMID: 9195681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiopulmonary manifestations of schistosomiasis. AU - Morris,W, AU - Knauer,C M, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 159 EP - 70 JF - Seminars in respiratory infections JO - Semin Respir Infect VL - 12 IS - 2 N2 - Three major schistosome species infect hundreds of millions of people worldwide. The majority of these infections are asymptomatic, but significant morbidity and mortality can occur as a consequence of ongoing egg deposition in host tissues. Acutely, transient chest radiographic abnormalities and nonspecific influenza-like symptoms can occur, including cough. The most common chronic pathological sequelae of schistosomiasis are those of portal hypertension with Schistosoma mansoni or S. japonicum, and genitourinary tract obstruction with S. haematobium. In less than 5% of infections, schistosomal egg obstruction of the lung vasculature results in pulmonary hypertension and cor pulmonale. Limited data suggests that cardiopulmonary schistosomiasis is seen most often in S. mansoni infections. Hepatic fibrosis and portal hypertension appear to be a prerequisite to the development of schistosomal cor pulmonale caused by this species. The premortem diagnosis of cardiopulmonary schistosomiasis depends on the detection of viable schistosomal ova in stool or urine along with evidence of characteristic hepatic fibrosis and pulmonary hypertension. Although treatment with praziquantel can effectively eradicate all schistosomal infections with minimal toxicity, cardiopulmonary manifestations are not likely to be reversible given the chronic fibrotic tissue changes that are present. SN - 0882-0546 UR - https://www.unboundmedicine.com/medline/citation/9195681/Cardiopulmonary_manifestations_of_schistosomiasis_ L2 - http://www.diseaseinfosearch.org/result/6440 DB - PRIME DP - Unbound Medicine ER -