Tags

Type your tag names separated by a space and hit enter

Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream.
Contact Dermatitis. 1997 May; 36(5):256-60.CD

Abstract

Moisturizers are used daily by many people to alleviate symptoms of clinically and subjectively dry skin. Recent studies suggest that certain ingredients in creams may accelerate the recovery of a disrupted barrier and decrease the skin susceptibility to irritant stimuli. In the present single-blind study, a moisturizing cream was tested for its influence both on barrier recovery in surfactant-damaged skin and on the susceptibility of normal skin to exposure to the irritant sodium lauryl sulphate (SLS). Parameters measured were transepidermal water loss (TEWL) and skin corneometer values, indicating degree of hydration. Treatment of surfactant-damaged skin with the test cream for 14 days promoted barrier recovery, as observed as a decrease in TEWL. Skin corneometer values also normalized more rapidly during the treatment. In normal skin, use of the test cream significantly reduced TEWL after 14 days of treatment, and irritant reactions to SLS were significantly decreased. Skin corneometer values increased after only 1 application and remained elevated after 14 days. In conclusion, the accelerated rate of recovery of surfactant-damaged skin and the lower degree of SLS-induced irritation in normal skin treated with the test cream may be of clinical relevance in attempts to reduce contact dermatitis due to irritant stimuli.

Authors+Show Affiliations

Department of Dermatology, University Hospital, Uppsala, Sweden.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9197961

Citation

Lodén, M. "Barrier Recovery and Influence of Irritant Stimuli in Skin Treated With a Moisturizing Cream." Contact Dermatitis, vol. 36, no. 5, 1997, pp. 256-60.
Lodén M. Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream. Contact Dermatitis. 1997;36(5):256-60.
Lodén, M. (1997). Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream. Contact Dermatitis, 36(5), 256-60.
Lodén M. Barrier Recovery and Influence of Irritant Stimuli in Skin Treated With a Moisturizing Cream. Contact Dermatitis. 1997;36(5):256-60. PubMed PMID: 9197961.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Barrier recovery and influence of irritant stimuli in skin treated with a moisturizing cream. A1 - Lodén,M, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 256 EP - 60 JF - Contact dermatitis JO - Contact Dermatitis VL - 36 IS - 5 N2 - Moisturizers are used daily by many people to alleviate symptoms of clinically and subjectively dry skin. Recent studies suggest that certain ingredients in creams may accelerate the recovery of a disrupted barrier and decrease the skin susceptibility to irritant stimuli. In the present single-blind study, a moisturizing cream was tested for its influence both on barrier recovery in surfactant-damaged skin and on the susceptibility of normal skin to exposure to the irritant sodium lauryl sulphate (SLS). Parameters measured were transepidermal water loss (TEWL) and skin corneometer values, indicating degree of hydration. Treatment of surfactant-damaged skin with the test cream for 14 days promoted barrier recovery, as observed as a decrease in TEWL. Skin corneometer values also normalized more rapidly during the treatment. In normal skin, use of the test cream significantly reduced TEWL after 14 days of treatment, and irritant reactions to SLS were significantly decreased. Skin corneometer values increased after only 1 application and remained elevated after 14 days. In conclusion, the accelerated rate of recovery of surfactant-damaged skin and the lower degree of SLS-induced irritation in normal skin treated with the test cream may be of clinical relevance in attempts to reduce contact dermatitis due to irritant stimuli. SN - 0105-1873 UR - https://www.unboundmedicine.com/medline/citation/9197961/Barrier_recovery_and_influence_of_irritant_stimuli_in_skin_treated_with_a_moisturizing_cream_ DB - PRIME DP - Unbound Medicine ER -