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S-allyl cysteine inhibits nitrosomorpholine formation and bioactivation.
Nutr Cancer. 1997; 28(1):1-6.NC

Abstract

Water extracts of garlic, deodorized garlic powder, and onions, but not leeks, were found to significantly (p < 0.05) reduce the in vitro formation of N-nitrosomorpholine (NMOR), a known liver carcinogen. Addition of increasing quantities (20, 40, and 80 mM) of S-allyl cysteine (SAC), a water-soluble compound in processed garlic, depressed NMOR formation by 16%, 27%, and 43%, respectively (p < 0.05). The ability of SAC to block NMOR formation decreased as the NaNO7 and morpholine concentrations increased. SAC and its non-allyl analog S-propyl cysteine effectively blocked NMOR formation. SAC and S-propyl cysteine were less effective than isomolar cysteine in reducing NMOR formation (p < 0.05). The oil-soluble sulfur compounds diallyl disulfide (DADS), dipropyl disulfide, and diallyl sulfide were ineffective inhibitors of NMOR generation (p > 0.05). SAC and DADS reduced the mutagenicity of NMOR in Salmonella typhimurium TA100 (p < 0.05). SAC at 70 mumol/plate reduced the number of histidine revertants per plate by 51% (p < 0.05), whereas DADS at 0.12 mumol/plate reduced mutant colony number by 76% (p < 0.05). SAC and DADS were more effective than isomolar cysteine in reducing NMOR mutagenicity (p < 0.05). The ability of sulfur compounds in garlic and onions to depress nitrosamine formation and bioactivation in these studies is consistent with epidemiologic evidence that higher intake of allium plants is associated with a reduction in the risks of some cancers.

Authors+Show Affiliations

Nutrition Department, Pennsylvania State University, University Park 16802, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9200143

Citation

Dion, M E., et al. "S-allyl Cysteine Inhibits Nitrosomorpholine Formation and Bioactivation." Nutrition and Cancer, vol. 28, no. 1, 1997, pp. 1-6.
Dion ME, Agler M, Milner JA. S-allyl cysteine inhibits nitrosomorpholine formation and bioactivation. Nutr Cancer. 1997;28(1):1-6.
Dion, M. E., Agler, M., & Milner, J. A. (1997). S-allyl cysteine inhibits nitrosomorpholine formation and bioactivation. Nutrition and Cancer, 28(1), 1-6.
Dion ME, Agler M, Milner JA. S-allyl Cysteine Inhibits Nitrosomorpholine Formation and Bioactivation. Nutr Cancer. 1997;28(1):1-6. PubMed PMID: 9200143.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - S-allyl cysteine inhibits nitrosomorpholine formation and bioactivation. AU - Dion,M E, AU - Agler,M, AU - Milner,J A, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 1 EP - 6 JF - Nutrition and cancer JO - Nutr Cancer VL - 28 IS - 1 N2 - Water extracts of garlic, deodorized garlic powder, and onions, but not leeks, were found to significantly (p < 0.05) reduce the in vitro formation of N-nitrosomorpholine (NMOR), a known liver carcinogen. Addition of increasing quantities (20, 40, and 80 mM) of S-allyl cysteine (SAC), a water-soluble compound in processed garlic, depressed NMOR formation by 16%, 27%, and 43%, respectively (p < 0.05). The ability of SAC to block NMOR formation decreased as the NaNO7 and morpholine concentrations increased. SAC and its non-allyl analog S-propyl cysteine effectively blocked NMOR formation. SAC and S-propyl cysteine were less effective than isomolar cysteine in reducing NMOR formation (p < 0.05). The oil-soluble sulfur compounds diallyl disulfide (DADS), dipropyl disulfide, and diallyl sulfide were ineffective inhibitors of NMOR generation (p > 0.05). SAC and DADS reduced the mutagenicity of NMOR in Salmonella typhimurium TA100 (p < 0.05). SAC at 70 mumol/plate reduced the number of histidine revertants per plate by 51% (p < 0.05), whereas DADS at 0.12 mumol/plate reduced mutant colony number by 76% (p < 0.05). SAC and DADS were more effective than isomolar cysteine in reducing NMOR mutagenicity (p < 0.05). The ability of sulfur compounds in garlic and onions to depress nitrosamine formation and bioactivation in these studies is consistent with epidemiologic evidence that higher intake of allium plants is associated with a reduction in the risks of some cancers. SN - 0163-5581 UR - https://www.unboundmedicine.com/medline/citation/9200143/S_allyl_cysteine_inhibits_nitrosomorpholine_formation_and_bioactivation_ L2 - https://www.tandfonline.com/doi/full/10.1080/01635589709514545 DB - PRIME DP - Unbound Medicine ER -