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Omeprazole-based dual and triple regimens for Helicobacter pylori eradication in children.
Pediatrics. 1997 Jul; 100(1):E3.Ped

Abstract

OBJECTIVE

To evaluate the efficacy and safety of omeprazole-based dual and triple regimens for the treatment of children with Helicobacter pylori infection.

METHODS

Twenty-two patients (3 with gastric ulcer, 12 with duodenal ulcer, and 7 with nodular gastritis alone) were studied. Twelve ulcer patients also had nodular gastritis. The dual regimen included a 2-week course of omeprazole (0.6 mg/kg twice a day) and amoxicillin (30 mg/kg twice a day) (n = 10), and the triple regimen included the dual regimen plus clarithromycin (15 mg/kg twice a day) (n = 12). In patients with active ulcers, omeprazole once daily was administered for another 4 weeks. Endoscopic biopsies were taken before therapy and 4 weeks after completion of a 2-week course of therapy, and patients were followed for 6 months. The gastritis score (grade 0 to 3) and serum anti-H pylori IgG antibody titers were also determined.

RESULTS

The regimens were tolerated by all patients. Eradication rates for the dual and triple regimens were 70% and 92%, respectively. Active ulcers completely healed within 6 weeks. Patients with nodular gastritis alone showed different clinical responses to therapy. Pretreatment histology showed chronic gastritis in all patients. Successful H pylori eradication significantly reduced the mean gastritis score from 2.9 to 1.3, but unsuccessful eradication did not reduce it. The disappearance of antral nodularity often coincided with the success of eradication. Successful eradication significantly decreased pretreatment serum anti-H pylori IgG antibody titers by 29% at 1 month, by 52% at 3 months, and by 67% at 6 months. Side effects were mild and were reported in 23% of patients.

CONCLUSION

An omeprazole-based regimen is safe and may be a better option for eradication of H pylori in children. Antral nodularity is a macroscopic marker of H pylori infection.

Authors+Show Affiliations

Department of Pediatrics, Sendai City Hospital, Sendai, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

9200377

Citation

Kato, S, et al. "Omeprazole-based Dual and Triple Regimens for Helicobacter Pylori Eradication in Children." Pediatrics, vol. 100, no. 1, 1997, pp. E3.
Kato S, Takeyama J, Ebina K, et al. Omeprazole-based dual and triple regimens for Helicobacter pylori eradication in children. Pediatrics. 1997;100(1):E3.
Kato, S., Takeyama, J., Ebina, K., & Naganuma, H. (1997). Omeprazole-based dual and triple regimens for Helicobacter pylori eradication in children. Pediatrics, 100(1), E3.
Kato S, et al. Omeprazole-based Dual and Triple Regimens for Helicobacter Pylori Eradication in Children. Pediatrics. 1997;100(1):E3. PubMed PMID: 9200377.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omeprazole-based dual and triple regimens for Helicobacter pylori eradication in children. AU - Kato,S, AU - Takeyama,J, AU - Ebina,K, AU - Naganuma,H, PY - 1997/7/1/pubmed PY - 1998/4/3/medline PY - 1997/7/1/entrez SP - E3 EP - E3 JF - Pediatrics JO - Pediatrics VL - 100 IS - 1 N2 - OBJECTIVE: To evaluate the efficacy and safety of omeprazole-based dual and triple regimens for the treatment of children with Helicobacter pylori infection. METHODS: Twenty-two patients (3 with gastric ulcer, 12 with duodenal ulcer, and 7 with nodular gastritis alone) were studied. Twelve ulcer patients also had nodular gastritis. The dual regimen included a 2-week course of omeprazole (0.6 mg/kg twice a day) and amoxicillin (30 mg/kg twice a day) (n = 10), and the triple regimen included the dual regimen plus clarithromycin (15 mg/kg twice a day) (n = 12). In patients with active ulcers, omeprazole once daily was administered for another 4 weeks. Endoscopic biopsies were taken before therapy and 4 weeks after completion of a 2-week course of therapy, and patients were followed for 6 months. The gastritis score (grade 0 to 3) and serum anti-H pylori IgG antibody titers were also determined. RESULTS: The regimens were tolerated by all patients. Eradication rates for the dual and triple regimens were 70% and 92%, respectively. Active ulcers completely healed within 6 weeks. Patients with nodular gastritis alone showed different clinical responses to therapy. Pretreatment histology showed chronic gastritis in all patients. Successful H pylori eradication significantly reduced the mean gastritis score from 2.9 to 1.3, but unsuccessful eradication did not reduce it. The disappearance of antral nodularity often coincided with the success of eradication. Successful eradication significantly decreased pretreatment serum anti-H pylori IgG antibody titers by 29% at 1 month, by 52% at 3 months, and by 67% at 6 months. Side effects were mild and were reported in 23% of patients. CONCLUSION: An omeprazole-based regimen is safe and may be a better option for eradication of H pylori in children. Antral nodularity is a macroscopic marker of H pylori infection. SN - 1098-4275 UR - https://www.unboundmedicine.com/medline/citation/9200377/Omeprazole_based_dual_and_triple_regimens_for_Helicobacter_pylori_eradication_in_children_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=9200377 DB - PRIME DP - Unbound Medicine ER -