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Effects of red wine on 24-hour esophageal pH and pressures in healthy volunteers.
Dig Dis Sci 1997; 42(6):1189-93DD

Abstract

The purpose of this study was to assess the effects of red wine taken with meals on esophageal motility, esophageal exposure to acid, and gastric pH. Following a randomized design, 14 healthy male volunteers (mean age 25 years, range 18-35 years were given 360 ml of red wine or tap water during lunch or dinner. All subjects underwent ambulatory 24-hr esophageal motility and esophagogastric pH monitoring studies. Three different periods were analyzed: during meals (30 min), postprandial (3 hr), and 8-hr supine. Two volunteers complained of heartburn after wine ingestion. An increase in the number of high amplitude waves (> 125 mm Hg, 95th percentile of our motility unit controls) was observed during meals accompanied by wine: water 1.2 (0-10.2), wine 1.6 (0-32.6), P = 0.02 [median (range)]. No other esophageal motility changes occurred. Percent reflux time increased during the postprandial period after wine ingestion in comparison with water: 1.7 (0-14.9) vs 0.1 (0-0.8), P < 0.05. Gastric pH was unaffected by the type of drink. Ingestion of moderate amounts of red wine with meals increases postprandial esophageal exposure to gastric acid in healthy persons.

Authors+Show Affiliations

Department of Surgery, Hospital Clinic i Provincial, University of Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9201083

Citation

Grande, L, et al. "Effects of Red Wine On 24-hour Esophageal pH and Pressures in Healthy Volunteers." Digestive Diseases and Sciences, vol. 42, no. 6, 1997, pp. 1189-93.
Grande L, Manterola C, Ros E, et al. Effects of red wine on 24-hour esophageal pH and pressures in healthy volunteers. Dig Dis Sci. 1997;42(6):1189-93.
Grande, L., Manterola, C., Ros, E., Lacima, G., & Pera, C. (1997). Effects of red wine on 24-hour esophageal pH and pressures in healthy volunteers. Digestive Diseases and Sciences, 42(6), pp. 1189-93.
Grande L, et al. Effects of Red Wine On 24-hour Esophageal pH and Pressures in Healthy Volunteers. Dig Dis Sci. 1997;42(6):1189-93. PubMed PMID: 9201083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of red wine on 24-hour esophageal pH and pressures in healthy volunteers. AU - Grande,L, AU - Manterola,C, AU - Ros,E, AU - Lacima,G, AU - Pera,C, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 1189 EP - 93 JF - Digestive diseases and sciences JO - Dig. Dis. Sci. VL - 42 IS - 6 N2 - The purpose of this study was to assess the effects of red wine taken with meals on esophageal motility, esophageal exposure to acid, and gastric pH. Following a randomized design, 14 healthy male volunteers (mean age 25 years, range 18-35 years were given 360 ml of red wine or tap water during lunch or dinner. All subjects underwent ambulatory 24-hr esophageal motility and esophagogastric pH monitoring studies. Three different periods were analyzed: during meals (30 min), postprandial (3 hr), and 8-hr supine. Two volunteers complained of heartburn after wine ingestion. An increase in the number of high amplitude waves (> 125 mm Hg, 95th percentile of our motility unit controls) was observed during meals accompanied by wine: water 1.2 (0-10.2), wine 1.6 (0-32.6), P = 0.02 [median (range)]. No other esophageal motility changes occurred. Percent reflux time increased during the postprandial period after wine ingestion in comparison with water: 1.7 (0-14.9) vs 0.1 (0-0.8), P < 0.05. Gastric pH was unaffected by the type of drink. Ingestion of moderate amounts of red wine with meals increases postprandial esophageal exposure to gastric acid in healthy persons. SN - 0163-2116 UR - https://www.unboundmedicine.com/medline/citation/9201083/Effects_of_red_wine_on_24_hour_esophageal_pH_and_pressures_in_healthy_volunteers_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9201083.ui DB - PRIME DP - Unbound Medicine ER -