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N(omega)-nitro-L-arginine methyl ester protects retinal neurons against N-methyl-D-aspartate-induced neurotoxicity in vivo.
Eur J Pharmacol. 1997 Jun 05; 328(1):45-9.EJ

Abstract

We investigated whether the inhibition of nitric oxide (NO) synthesis with N(omega)-nitro-L-arginine methyl ester (L-NAME), a competitive inhibitor of NO synthase, affects N-methyl-D-aspartate (NMDA)-induced neurotoxicity in the rat retina in vivo. A single intravitreal injection of NMDA damaged the ganglion cell layer and the inner plexiform layer without affecting the other retinal layers 7 days after injection. Intravitreal injection of (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5, 10-imine hydrogen maleate (MK-801) with NMDA significantly reduced NMDA-induced degeneration of the retina. NMDA-induced degeneration was also prevented by intravitreal injection of L-NAME but not of D-NAME. The protective effect of L-NAME was antagonized by L-arginine. These results suggest that NO plays an important role in NMDA-induced excitotoxic degeneration in the retina.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9203567

Citation

Morizane, C, et al. "N(omega)-nitro-L-arginine Methyl Ester Protects Retinal Neurons Against N-methyl-D-aspartate-induced Neurotoxicity in Vivo." European Journal of Pharmacology, vol. 328, no. 1, 1997, pp. 45-9.
Morizane C, Adachi K, Furutani I, et al. N(omega)-nitro-L-arginine methyl ester protects retinal neurons against N-methyl-D-aspartate-induced neurotoxicity in vivo. Eur J Pharmacol. 1997;328(1):45-9.
Morizane, C., Adachi, K., Furutani, I., Fujita, Y., Akaike, A., Kashii, S., & Honda, Y. (1997). N(omega)-nitro-L-arginine methyl ester protects retinal neurons against N-methyl-D-aspartate-induced neurotoxicity in vivo. European Journal of Pharmacology, 328(1), 45-9.
Morizane C, et al. N(omega)-nitro-L-arginine Methyl Ester Protects Retinal Neurons Against N-methyl-D-aspartate-induced Neurotoxicity in Vivo. Eur J Pharmacol. 1997 Jun 5;328(1):45-9. PubMed PMID: 9203567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - N(omega)-nitro-L-arginine methyl ester protects retinal neurons against N-methyl-D-aspartate-induced neurotoxicity in vivo. AU - Morizane,C, AU - Adachi,K, AU - Furutani,I, AU - Fujita,Y, AU - Akaike,A, AU - Kashii,S, AU - Honda,Y, PY - 1997/6/5/pubmed PY - 1997/6/5/medline PY - 1997/6/5/entrez SP - 45 EP - 9 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 328 IS - 1 N2 - We investigated whether the inhibition of nitric oxide (NO) synthesis with N(omega)-nitro-L-arginine methyl ester (L-NAME), a competitive inhibitor of NO synthase, affects N-methyl-D-aspartate (NMDA)-induced neurotoxicity in the rat retina in vivo. A single intravitreal injection of NMDA damaged the ganglion cell layer and the inner plexiform layer without affecting the other retinal layers 7 days after injection. Intravitreal injection of (5R,10S)-(+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclo-hepten-5, 10-imine hydrogen maleate (MK-801) with NMDA significantly reduced NMDA-induced degeneration of the retina. NMDA-induced degeneration was also prevented by intravitreal injection of L-NAME but not of D-NAME. The protective effect of L-NAME was antagonized by L-arginine. These results suggest that NO plays an important role in NMDA-induced excitotoxic degeneration in the retina. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/9203567/N_omega__nitro_L_arginine_methyl_ester_protects_retinal_neurons_against_N_methyl_D_aspartate_induced_neurotoxicity_in_vivo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(97)83026-9 DB - PRIME DP - Unbound Medicine ER -