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Cholecystokinin in transient lower oesophageal sphincter relaxation due to gastric distension in humans.
Gut. 1997 May; 40(5):575-81.Gut

Abstract

BACKGROUND AND AIMS

Transient lower oesophageal sphincter relaxations (TLOSRs) has been found to be the main mechanism of gastro-oesophageal reflux. In dogs, cholecystokinin (CCK) is involved in their occurrence. The aim was to evaluate the role of endogenous and exogenous CCK in the occurrence of TLOSRs induced by gastric distension at constant pressure in humans.

METHODS

Ten healthy volunteers were studied. Lower oesophageal sphincter pressure was monitored with a sleeve device and gastric distension was performed via an intragastric bag monitored by a barostat. During distensions, saline, CCK (30 ng/kg/h) or the CCK-A receptor antagonist loxiglumide (10 mg/kg/h) was perfused in a random double blind order.

RESULTS

There was no significant difference between the number of TLOSRs during the different distensions with saline; CCK increased the number of TLOSRs at a mean rate of 13.1 compared with 9.1 with saline (p < 0.001). Loxiglumide significantly decreased the number of relaxations to 5.3 versus 8.3 under paired saline infusion (p < 0.001).

CONCLUSIONS

In humans, CCK-A receptor subtype is involved in the occurrence of transient lower oesophageal sphincter relaxations induced by gastric distension.

Authors+Show Affiliations

Department of Gastroenterology, Hôtel-Dieu, Clermont-Ferrand, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9203932

Citation

Boulant, J, et al. "Cholecystokinin in Transient Lower Oesophageal Sphincter Relaxation Due to Gastric Distension in Humans." Gut, vol. 40, no. 5, 1997, pp. 575-81.
Boulant J, Mathieu S, D'Amato M, et al. Cholecystokinin in transient lower oesophageal sphincter relaxation due to gastric distension in humans. Gut. 1997;40(5):575-81.
Boulant, J., Mathieu, S., D'Amato, M., Abergel, A., Dapoigny, M., & Bommelaer, G. (1997). Cholecystokinin in transient lower oesophageal sphincter relaxation due to gastric distension in humans. Gut, 40(5), 575-81.
Boulant J, et al. Cholecystokinin in Transient Lower Oesophageal Sphincter Relaxation Due to Gastric Distension in Humans. Gut. 1997;40(5):575-81. PubMed PMID: 9203932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholecystokinin in transient lower oesophageal sphincter relaxation due to gastric distension in humans. AU - Boulant,J, AU - Mathieu,S, AU - D'Amato,M, AU - Abergel,A, AU - Dapoigny,M, AU - Bommelaer,G, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 575 EP - 81 JF - Gut JO - Gut VL - 40 IS - 5 N2 - BACKGROUND AND AIMS: Transient lower oesophageal sphincter relaxations (TLOSRs) has been found to be the main mechanism of gastro-oesophageal reflux. In dogs, cholecystokinin (CCK) is involved in their occurrence. The aim was to evaluate the role of endogenous and exogenous CCK in the occurrence of TLOSRs induced by gastric distension at constant pressure in humans. METHODS: Ten healthy volunteers were studied. Lower oesophageal sphincter pressure was monitored with a sleeve device and gastric distension was performed via an intragastric bag monitored by a barostat. During distensions, saline, CCK (30 ng/kg/h) or the CCK-A receptor antagonist loxiglumide (10 mg/kg/h) was perfused in a random double blind order. RESULTS: There was no significant difference between the number of TLOSRs during the different distensions with saline; CCK increased the number of TLOSRs at a mean rate of 13.1 compared with 9.1 with saline (p < 0.001). Loxiglumide significantly decreased the number of relaxations to 5.3 versus 8.3 under paired saline infusion (p < 0.001). CONCLUSIONS: In humans, CCK-A receptor subtype is involved in the occurrence of transient lower oesophageal sphincter relaxations induced by gastric distension. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/9203932/Cholecystokinin_in_transient_lower_oesophageal_sphincter_relaxation_due_to_gastric_distension_in_humans_ L2 - https://gut.bmj.com/lookup/pmidlookup?view=long&amp;pmid=9203932 DB - PRIME DP - Unbound Medicine ER -