Tags

Type your tag names separated by a space and hit enter

A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13.
Genomics. 1997 Jun 15; 42(3):405-12.G

Abstract

A transcription map of a 1200-kb region encompassing the MEN1 locus was constructed by direct cDNA selection and mapping ESTs. A total of 29 genes were mapped. Ten transcripts were identified by cDNA selection of a focused 300-kb genomic region telomeric to the MEN1 consensus region. Since many of the sequences cloned by cDNA selection also identified ESTs from the region, 19 additional RH-mapped ESTs were mapped to the entire contig region by PCR amplification of genomic clones. Nine known genes, 2 putative human homologues to mouse genes, and 18 novel transcripts map to the region. Transcripts that map to the MEN1 interval PYGM-D11S449 include SGC35223, IB1256, AA147620, ZFM1, FAU, and CAPN1. The latter 3 known genes have already been excluded as candidate MEN1 genes. The 2 putative human homologues of mouse genes Ltbp2 and Spa-1 may be candidate tumor suppressor genes, but they map telomeric to D11S449. Although both of these genes map outside the MEN1 consensus region they may play a role in sporadic endocrine tumors independent of the MEN1 gene or in other tumors, such as breast cancer, that have loss of heterozygosity within this region.

Authors+Show Affiliations

Department of Surgery Molecular Biology Core Unit, West Los Angeles Veterans Administration Medical Center, California 90073, USA. msawicki@ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

9205112

Citation

Sawicki, M, et al. "A Transcript Map Encompassing the Multiple Endocrine Neoplasia Type-1 (MEN1) Locus On Chromosome 11q13." Genomics, vol. 42, no. 3, 1997, pp. 405-12.
Sawicki M, Arnold E, Ebrahimi S, et al. A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13. Genomics. 1997;42(3):405-12.
Sawicki, M., Arnold, E., Ebrahimi, S., Duell, T., Jin, S., Wood, T., Chakrabarti, R., Peters, J., Wan, Y., Samara, G., Weier, H. U., Udar, N., Passaro, E., & Srivatsan, E. S. (1997). A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13. Genomics, 42(3), 405-12.
Sawicki M, et al. A Transcript Map Encompassing the Multiple Endocrine Neoplasia Type-1 (MEN1) Locus On Chromosome 11q13. Genomics. 1997 Jun 15;42(3):405-12. PubMed PMID: 9205112.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A transcript map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13. AU - Sawicki,M, AU - Arnold,E, AU - Ebrahimi,S, AU - Duell,T, AU - Jin,S, AU - Wood,T, AU - Chakrabarti,R, AU - Peters,J, AU - Wan,Y, AU - Samara,G, AU - Weier,H U, AU - Udar,N, AU - Passaro,E,Jr AU - Srivatsan,E S, PY - 1997/6/15/pubmed PY - 2001/3/28/medline PY - 1997/6/15/entrez SP - 405 EP - 12 JF - Genomics JO - Genomics VL - 42 IS - 3 N2 - A transcription map of a 1200-kb region encompassing the MEN1 locus was constructed by direct cDNA selection and mapping ESTs. A total of 29 genes were mapped. Ten transcripts were identified by cDNA selection of a focused 300-kb genomic region telomeric to the MEN1 consensus region. Since many of the sequences cloned by cDNA selection also identified ESTs from the region, 19 additional RH-mapped ESTs were mapped to the entire contig region by PCR amplification of genomic clones. Nine known genes, 2 putative human homologues to mouse genes, and 18 novel transcripts map to the region. Transcripts that map to the MEN1 interval PYGM-D11S449 include SGC35223, IB1256, AA147620, ZFM1, FAU, and CAPN1. The latter 3 known genes have already been excluded as candidate MEN1 genes. The 2 putative human homologues of mouse genes Ltbp2 and Spa-1 may be candidate tumor suppressor genes, but they map telomeric to D11S449. Although both of these genes map outside the MEN1 consensus region they may play a role in sporadic endocrine tumors independent of the MEN1 gene or in other tumors, such as breast cancer, that have loss of heterozygosity within this region. SN - 0888-7543 UR - https://www.unboundmedicine.com/medline/citation/9205112/A_transcript_map_encompassing_the_multiple_endocrine_neoplasia_type_1__MEN1__locus_on_chromosome_11q13_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0888-7543(97)94773-X DB - PRIME DP - Unbound Medicine ER -