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Pancreatic endocrine tumors with loss of heterozygosity at the multiple endocrine neoplasia type I locus.
Am J Surg. 1997 Jun; 173(6):518-20.AJ

Abstract

BACKGROUND

Loss of heterozygosity (LOH) at chromosome 11q13 has been demonstrated in multiple endocrine neoplasia type I (MEN I) and sporadic parathyroid tumors, pituitary adenomas, and a few types of pancreatic endocrine tumors. Gastrinomas are the most common pancreatic endocrine tumor in MEN I. We hypothesized that all pancreatic endocrine tumors have LOH at 11q13, resulting in inactivation of the previously described tumor suppressor gene in this region.

METHODS

We analyzed a sporadic gastrinoma, a MEN I-associated gastrinoma, and a nonfunctional pancreatic endocrine tumor from a patient with Von Hippel-Lindau (VHL) disease for LOH at seven loci at 11q13: D11S149, PYGM, D11S427, D11S546, SEA, D11S97, and D11S146.

RESULTS AND CONCLUSIONS

We found LOH at 11q13 in all three tumors. The MEN I-associated gastrinoma we analyzed is the first tumor of this type to have LOH. This is also the first report of LOH at 11q13 in a pancreatic endocrine tumor from a patient with VHL. These findings suggest that the etiology of pancreatic endocrine tumor formation involves a common genetic pathway for sporadic, MEN I, and VHL tumors.

Authors+Show Affiliations

Department of Surgery, Harbor-UCLA Medical Center, Torrance, California 90509, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9207166

Citation

Eubanks, P J., et al. "Pancreatic Endocrine Tumors With Loss of Heterozygosity at the Multiple Endocrine Neoplasia Type I Locus." American Journal of Surgery, vol. 173, no. 6, 1997, pp. 518-20.
Eubanks PJ, Sawicki MP, Samara GJ, et al. Pancreatic endocrine tumors with loss of heterozygosity at the multiple endocrine neoplasia type I locus. Am J Surg. 1997;173(6):518-20.
Eubanks, P. J., Sawicki, M. P., Samara, G. J., Wan, Y. J., Gatti, R. A., Hurwitz, M., & Passaro, E. (1997). Pancreatic endocrine tumors with loss of heterozygosity at the multiple endocrine neoplasia type I locus. American Journal of Surgery, 173(6), 518-20.
Eubanks PJ, et al. Pancreatic Endocrine Tumors With Loss of Heterozygosity at the Multiple Endocrine Neoplasia Type I Locus. Am J Surg. 1997;173(6):518-20. PubMed PMID: 9207166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic endocrine tumors with loss of heterozygosity at the multiple endocrine neoplasia type I locus. AU - Eubanks,P J, AU - Sawicki,M P, AU - Samara,G J, AU - Wan,Y J, AU - Gatti,R A, AU - Hurwitz,M, AU - Passaro,E,Jr PY - 1997/6/1/pubmed PY - 2001/3/28/medline PY - 1997/6/1/entrez SP - 518 EP - 20 JF - American journal of surgery JO - Am J Surg VL - 173 IS - 6 N2 - BACKGROUND: Loss of heterozygosity (LOH) at chromosome 11q13 has been demonstrated in multiple endocrine neoplasia type I (MEN I) and sporadic parathyroid tumors, pituitary adenomas, and a few types of pancreatic endocrine tumors. Gastrinomas are the most common pancreatic endocrine tumor in MEN I. We hypothesized that all pancreatic endocrine tumors have LOH at 11q13, resulting in inactivation of the previously described tumor suppressor gene in this region. METHODS: We analyzed a sporadic gastrinoma, a MEN I-associated gastrinoma, and a nonfunctional pancreatic endocrine tumor from a patient with Von Hippel-Lindau (VHL) disease for LOH at seven loci at 11q13: D11S149, PYGM, D11S427, D11S546, SEA, D11S97, and D11S146. RESULTS AND CONCLUSIONS: We found LOH at 11q13 in all three tumors. The MEN I-associated gastrinoma we analyzed is the first tumor of this type to have LOH. This is also the first report of LOH at 11q13 in a pancreatic endocrine tumor from a patient with VHL. These findings suggest that the etiology of pancreatic endocrine tumor formation involves a common genetic pathway for sporadic, MEN I, and VHL tumors. SN - 0002-9610 UR - https://www.unboundmedicine.com/medline/citation/9207166/Pancreatic_endocrine_tumors_with_loss_of_heterozygosity_at_the_multiple_endocrine_neoplasia_type_I_locus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002961097000019 DB - PRIME DP - Unbound Medicine ER -