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Low serum HDL-cholesterol is associated with raised tumor necrosis factor-alpha during ENL reactions.
Int J Lepr Other Mycobact Dis. 1997 Mar; 65(1):1-11.IJ

Abstract

The concentrations of serum lipids and tumor necrosis factor (TNF) were measured in leprosy patients across the spectrum of the disease and in erythema nodosum leprosum (ENL) patients at the onset of the reaction and after the reaction had clinically subsided. Lepromatous/borderline lepromatous (LL/BL) patients had significantly higher serum triglyceride and lower HDL-cholesterol levels; there was no such change in the tuberculoid/borderline tuberculoid (TT/BT) patients. The household contacts (HC) of the LL/BL patients also had significantly lower serum HDL levels. ENL patients during the acute phase of the reaction had significantly lower total, LDL-, HDL-cholesterol levels compared to the stable LL/BL patients, and these changes were reversible to pre-ENL levels after the reaction had subsided. Serum TNF levels were significantly higher in household contacts and in LL/BL patients but were not statistically different in TT/BT patients. Serum TNF levels were also significantly higher during the acute phase of ENL, and declined after the clinical remission of the reaction to levels comparable with those of LL/BL patients. There was a significant negative correlation between serum TNF and HDL-cholesterol levels during and after ENL reaction. However, there was no such correlation between TNF and total or LDL-cholesterol levels in ENL patients. Our results suggest that the changes in HDL-cholesterol metabolism are a specific part of the host response to lepromatous leprosy and to the ENL reaction and may be mediated by increased TNF production.

Authors+Show Affiliations

Department of Physiology and Pharmacology, Aga Khan University, Karachi, Pakistan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9207748

Citation

Memon, R A., et al. "Low Serum HDL-cholesterol Is Associated With Raised Tumor Necrosis Factor-alpha During ENL Reactions." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 65, no. 1, 1997, pp. 1-11.
Memon RA, Kifayet A, Shahid F, et al. Low serum HDL-cholesterol is associated with raised tumor necrosis factor-alpha during ENL reactions. Int J Lepr Other Mycobact Dis. 1997;65(1):1-11.
Memon, R. A., Kifayet, A., Shahid, F., Lateef, A., Chiang, J., & Hussain, R. (1997). Low serum HDL-cholesterol is associated with raised tumor necrosis factor-alpha during ENL reactions. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 65(1), 1-11.
Memon RA, et al. Low Serum HDL-cholesterol Is Associated With Raised Tumor Necrosis Factor-alpha During ENL Reactions. Int J Lepr Other Mycobact Dis. 1997;65(1):1-11. PubMed PMID: 9207748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low serum HDL-cholesterol is associated with raised tumor necrosis factor-alpha during ENL reactions. AU - Memon,R A, AU - Kifayet,A, AU - Shahid,F, AU - Lateef,A, AU - Chiang,J, AU - Hussain,R, PY - 1997/3/1/pubmed PY - 1997/3/1/medline PY - 1997/3/1/entrez SP - 1 EP - 11 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 65 IS - 1 N2 - The concentrations of serum lipids and tumor necrosis factor (TNF) were measured in leprosy patients across the spectrum of the disease and in erythema nodosum leprosum (ENL) patients at the onset of the reaction and after the reaction had clinically subsided. Lepromatous/borderline lepromatous (LL/BL) patients had significantly higher serum triglyceride and lower HDL-cholesterol levels; there was no such change in the tuberculoid/borderline tuberculoid (TT/BT) patients. The household contacts (HC) of the LL/BL patients also had significantly lower serum HDL levels. ENL patients during the acute phase of the reaction had significantly lower total, LDL-, HDL-cholesterol levels compared to the stable LL/BL patients, and these changes were reversible to pre-ENL levels after the reaction had subsided. Serum TNF levels were significantly higher in household contacts and in LL/BL patients but were not statistically different in TT/BT patients. Serum TNF levels were also significantly higher during the acute phase of ENL, and declined after the clinical remission of the reaction to levels comparable with those of LL/BL patients. There was a significant negative correlation between serum TNF and HDL-cholesterol levels during and after ENL reaction. However, there was no such correlation between TNF and total or LDL-cholesterol levels in ENL patients. Our results suggest that the changes in HDL-cholesterol metabolism are a specific part of the host response to lepromatous leprosy and to the ENL reaction and may be mediated by increased TNF production. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/9207748/Low_serum_HDL_cholesterol_is_associated_with_raised_tumor_necrosis_factor_alpha_during_ENL_reactions_ L2 - https://medlineplus.gov/hdlthegoodcholesterol.html DB - PRIME DP - Unbound Medicine ER -