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Cytokeratins, CEA, and mucin histochemistry in the diagnosis and characterization of extramammary Paget's disease.
Am J Clin Pathol. 1997 Jul; 108(1):6-12.AJ

Abstract

To identify a sensitive marker for extramammary Paget's disease and to identify histochemical and immunohistochemical features that suggest occult pelvic cancer in patients with extramammary Paget's disease, we retrieved all cases between 1983 and 1992 with a Standardized Nomenclature of Medicine code of extramammary Paget's disease in the Vanderbilt University Medical Center (Nashville, Tenn) surgical pathology archives. All were stained for alcian blue/dPAS (periodic acid-Schiff), mucicarmine, AE1/AE3, cytokeratin (CAM 5.2), cytokeratin (CK) 7, CK 20, carcinoembryonic antigen (CEA), orthokeratin, prostate-specific antigen, and S-100. Sixteen cases (2 men, 14 women) were retrieved. Two had pelvic malignancies: one rectal adenocarcinoma and one transitional carcinoma. Only CK7 marked all cases. Mucins were sensitive but focal, a potential problem in small biopsy specimens. The transitional tumor had a unique staining profile (CEA- and mucin-negative). CK20 strongly marked Paget cells associated with rectal cancer; its presence suggests a large bowel lesion but is not specific. No case expressed prostate-specific antigen; its presence in a man suggests prostatic carcinoma.

Authors+Show Affiliations

Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2561, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9208972

Citation

Battles, O E., et al. "Cytokeratins, CEA, and Mucin Histochemistry in the Diagnosis and Characterization of Extramammary Paget's Disease." American Journal of Clinical Pathology, vol. 108, no. 1, 1997, pp. 6-12.
Battles OE, Page DL, Johnson JE. Cytokeratins, CEA, and mucin histochemistry in the diagnosis and characterization of extramammary Paget's disease. Am J Clin Pathol. 1997;108(1):6-12.
Battles, O. E., Page, D. L., & Johnson, J. E. (1997). Cytokeratins, CEA, and mucin histochemistry in the diagnosis and characterization of extramammary Paget's disease. American Journal of Clinical Pathology, 108(1), 6-12.
Battles OE, Page DL, Johnson JE. Cytokeratins, CEA, and Mucin Histochemistry in the Diagnosis and Characterization of Extramammary Paget's Disease. Am J Clin Pathol. 1997;108(1):6-12. PubMed PMID: 9208972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokeratins, CEA, and mucin histochemistry in the diagnosis and characterization of extramammary Paget's disease. AU - Battles,O E, AU - Page,D L, AU - Johnson,J E, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 6 EP - 12 JF - American journal of clinical pathology JO - Am. J. Clin. Pathol. VL - 108 IS - 1 N2 - To identify a sensitive marker for extramammary Paget's disease and to identify histochemical and immunohistochemical features that suggest occult pelvic cancer in patients with extramammary Paget's disease, we retrieved all cases between 1983 and 1992 with a Standardized Nomenclature of Medicine code of extramammary Paget's disease in the Vanderbilt University Medical Center (Nashville, Tenn) surgical pathology archives. All were stained for alcian blue/dPAS (periodic acid-Schiff), mucicarmine, AE1/AE3, cytokeratin (CAM 5.2), cytokeratin (CK) 7, CK 20, carcinoembryonic antigen (CEA), orthokeratin, prostate-specific antigen, and S-100. Sixteen cases (2 men, 14 women) were retrieved. Two had pelvic malignancies: one rectal adenocarcinoma and one transitional carcinoma. Only CK7 marked all cases. Mucins were sensitive but focal, a potential problem in small biopsy specimens. The transitional tumor had a unique staining profile (CEA- and mucin-negative). CK20 strongly marked Paget cells associated with rectal cancer; its presence suggests a large bowel lesion but is not specific. No case expressed prostate-specific antigen; its presence in a man suggests prostatic carcinoma. SN - 0002-9173 UR - https://www.unboundmedicine.com/medline/citation/9208972/Cytokeratins_CEA_and_mucin_histochemistry_in_the_diagnosis_and_characterization_of_extramammary_Paget's_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9208972.ui DB - PRIME DP - Unbound Medicine ER -