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A prospective study of alcohol, smoking, caffeine, and the risk of duodenal ulcer in men.

Abstract

The associations between smoking, caffeine, and alcohol intake and the risk of duodenal ulcer have rarely been investigated prospectively. We examined these associations in a prospective cohort of 47,806 men, 40-75 years of age, using a mailed baseline questionnaire in 1986, with follow-up every 2 years through 1992. During 6 years of follow-up, we documented 138 newly diagnosed cases of duodenal ulcer. After adjustment for age, energy-adjusted dietary fiber, body mass index, and use of aspirin or other nonsteroidal antiinflammatory drugs, current smoking was not associated with a substantial risk of duodenal ulcer [relative risk (RR) = 1.07; 95% confidence interval (CI) = 0.61-1.89]. Overall, past smokers were not at increased risk compared with never-smokers (RR = 0.99; 95% CI = 0.69-1.42). Adjusting for other risk factors, alcohol intake (comparing those who drink > 30 gm of alcohol per day to nondrinkers) was not associated with higher risk of duodenal ulcer (RR = 0.74; 95% CI = 0.42-1.29). We observed little association between caffeine, caffeine-containing beverages, and decaffeinated coffee and the risk of duodenal ulcer. These results indicate that smoking is not associated with a substantial increase in risk of duodenal ulcer, nor is high intake of alcohol and caffeine.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.

    , , , ,

    Source

    Epidemiology (Cambridge, Mass.) 8:4 1997 Jul pg 420-4

    MeSH

    Adult
    Aged
    Alcohol Drinking
    Caffeine
    Confidence Intervals
    Duodenal Ulcer
    Health Personnel
    Humans
    Logistic Models
    Male
    Middle Aged
    Prospective Studies
    Risk
    Smoking
    United States

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9209857

    Citation

    Aldoori, W H., et al. "A Prospective Study of Alcohol, Smoking, Caffeine, and the Risk of Duodenal Ulcer in Men." Epidemiology (Cambridge, Mass.), vol. 8, no. 4, 1997, pp. 420-4.
    Aldoori WH, Giovannucci EL, Stampfer MJ, et al. A prospective study of alcohol, smoking, caffeine, and the risk of duodenal ulcer in men. Epidemiology. 1997;8(4):420-4.
    Aldoori, W. H., Giovannucci, E. L., Stampfer, M. J., Rimm, E. B., Wing, A. L., & Willett, W. C. (1997). A prospective study of alcohol, smoking, caffeine, and the risk of duodenal ulcer in men. Epidemiology (Cambridge, Mass.), 8(4), pp. 420-4.
    Aldoori WH, et al. A Prospective Study of Alcohol, Smoking, Caffeine, and the Risk of Duodenal Ulcer in Men. Epidemiology. 1997;8(4):420-4. PubMed PMID: 9209857.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - A prospective study of alcohol, smoking, caffeine, and the risk of duodenal ulcer in men. AU - Aldoori,W H, AU - Giovannucci,E L, AU - Stampfer,M J, AU - Rimm,E B, AU - Wing,A L, AU - Willett,W C, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 420 EP - 4 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 8 IS - 4 N2 - The associations between smoking, caffeine, and alcohol intake and the risk of duodenal ulcer have rarely been investigated prospectively. We examined these associations in a prospective cohort of 47,806 men, 40-75 years of age, using a mailed baseline questionnaire in 1986, with follow-up every 2 years through 1992. During 6 years of follow-up, we documented 138 newly diagnosed cases of duodenal ulcer. After adjustment for age, energy-adjusted dietary fiber, body mass index, and use of aspirin or other nonsteroidal antiinflammatory drugs, current smoking was not associated with a substantial risk of duodenal ulcer [relative risk (RR) = 1.07; 95% confidence interval (CI) = 0.61-1.89]. Overall, past smokers were not at increased risk compared with never-smokers (RR = 0.99; 95% CI = 0.69-1.42). Adjusting for other risk factors, alcohol intake (comparing those who drink > 30 gm of alcohol per day to nondrinkers) was not associated with higher risk of duodenal ulcer (RR = 0.74; 95% CI = 0.42-1.29). We observed little association between caffeine, caffeine-containing beverages, and decaffeinated coffee and the risk of duodenal ulcer. These results indicate that smoking is not associated with a substantial increase in risk of duodenal ulcer, nor is high intake of alcohol and caffeine. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/9209857/A_prospective_study_of_alcohol_smoking_caffeine_and_the_risk_of_duodenal_ulcer_in_men_ L2 - http://Insights.ovid.com/pubmed?pmid=9209857 DB - PRIME DP - Unbound Medicine ER -