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The results of intraoperative consultations in 181 ductal carcinomas in situ of the breast.
Cancer. 1997 Jul 01; 80(1):75-9.C

Abstract

BACKGROUND

The utility of frozen section (FS) examination in the intraoperative management of breast lesions is well established. The accuracy of FS in the diagnosis of borderline noninvasive or preinvasive breast lesions is uncertain.

METHODS

The authors retrospectively reviewed the results of intraoperative consultations/frozen section examinations of 181 ductal carcinomas in situ (DCIS) of the breast. Various clinical and pathologic factors were analyzed and correlated with FS diagnosis.

RESULTS

FS examination was performed on 153 cases (85%) and only macroscopic examination on 28 cases (15%). FS diagnoses were as follows: DCIS in 76 cases (50%), atypical ductal hyperplasia/suspicious for DCIS in 8 cases (5%), benign in 55 cases (36%), deferred in 13 cases (8%), and invasive carcinoma in 1 case. FS accuracy, false-negative rate, and false-positive rate were 55%, 36%, and 0.6%, respectively. Sampling error was the main reason for the low detection rate, and technical inadequacy was a major factor contributing to interpretive problems. In multivariate regression analysis, FS accuracy was significantly associated with the clinical presentation of a palpable mass (odds ratio [OR] = 4.16, 95% confidence interval [CI]: 2.04-8.45), the macroscopic finding of a mass (OR = 3.03, 95% CI: 1.45-6.67), and necrosis (OR = 3.13, 95% CI: 1.4-6.67).

CONCLUSIONS

The authors concluded that the accuracy of FS diagnosis of DCIS was low, mainly due to sampling error. In general, FS examination should not be performed when no lesion/mass is identified by macroscopic examination.

Authors+Show Affiliations

The Institute of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Ohio 44106, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9210711

Citation

Cheng, L, et al. "The Results of Intraoperative Consultations in 181 Ductal Carcinomas in Situ of the Breast." Cancer, vol. 80, no. 1, 1997, pp. 75-9.
Cheng L, Al-Kaisi NK, Liu AY, et al. The results of intraoperative consultations in 181 ductal carcinomas in situ of the breast. Cancer. 1997;80(1):75-9.
Cheng, L., Al-Kaisi, N. K., Liu, A. Y., & Gordon, N. H. (1997). The results of intraoperative consultations in 181 ductal carcinomas in situ of the breast. Cancer, 80(1), 75-9.
Cheng L, et al. The Results of Intraoperative Consultations in 181 Ductal Carcinomas in Situ of the Breast. Cancer. 1997 Jul 1;80(1):75-9. PubMed PMID: 9210711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The results of intraoperative consultations in 181 ductal carcinomas in situ of the breast. AU - Cheng,L, AU - Al-Kaisi,N K, AU - Liu,A Y, AU - Gordon,N H, PY - 1997/7/1/pubmed PY - 2000/6/20/medline PY - 1997/7/1/entrez SP - 75 EP - 9 JF - Cancer JO - Cancer VL - 80 IS - 1 N2 - BACKGROUND: The utility of frozen section (FS) examination in the intraoperative management of breast lesions is well established. The accuracy of FS in the diagnosis of borderline noninvasive or preinvasive breast lesions is uncertain. METHODS: The authors retrospectively reviewed the results of intraoperative consultations/frozen section examinations of 181 ductal carcinomas in situ (DCIS) of the breast. Various clinical and pathologic factors were analyzed and correlated with FS diagnosis. RESULTS: FS examination was performed on 153 cases (85%) and only macroscopic examination on 28 cases (15%). FS diagnoses were as follows: DCIS in 76 cases (50%), atypical ductal hyperplasia/suspicious for DCIS in 8 cases (5%), benign in 55 cases (36%), deferred in 13 cases (8%), and invasive carcinoma in 1 case. FS accuracy, false-negative rate, and false-positive rate were 55%, 36%, and 0.6%, respectively. Sampling error was the main reason for the low detection rate, and technical inadequacy was a major factor contributing to interpretive problems. In multivariate regression analysis, FS accuracy was significantly associated with the clinical presentation of a palpable mass (odds ratio [OR] = 4.16, 95% confidence interval [CI]: 2.04-8.45), the macroscopic finding of a mass (OR = 3.03, 95% CI: 1.45-6.67), and necrosis (OR = 3.13, 95% CI: 1.4-6.67). CONCLUSIONS: The authors concluded that the accuracy of FS diagnosis of DCIS was low, mainly due to sampling error. In general, FS examination should not be performed when no lesion/mass is identified by macroscopic examination. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/9210711/The_results_of_intraoperative_consultations_in_181_ductal_carcinomas_in_situ_of_the_breast_ L2 - https://medlineplus.gov/breastcancer.html DB - PRIME DP - Unbound Medicine ER -