Tags

Type your tag names separated by a space and hit enter

Eosinophilia and intracranial worm recovery in interleukin-5 transgenic and interleukin-5 receptor alpha chain-knockout mice infected with Angiostrongylus cantonensis.
Parasitol Res. 1997; 83(6):583-90.PR

Abstract

We infected interleukin-5 (IL-5)-transgenic (IL-5-Tg) and IL-5 receptor alpha knockout (IL-5R alpha -/-) mice with Angiostrongylus cantonensis to determine the possible roles of IL-5 and eosinophils in A. cantonensis infection in mice. IL-5-Tg mice demonstrated significantly higher eosinophilia in bone marrow, blood and cerebrospinal fluid (CSF), lower intracranial worm recovery and smaller female worms than naive C3H/HeN mice. Both IL-5-Tg and C3H/HeN mice evoked antigen-specific serum and CSF IgA antibody responses as early as days 5 and 7 postinfection, respectively. Prominent eosinophil infiltration was noted around intracranial worms in the subarachnoid spaces of the mouse brains; eosinophils adhering to the worm surface were degranulated. In contrast, IL-5R alpha -/- mice yielded a higher worm recovery than wild-type or heterozygous mice at day 20 postinfection and failed to provoke CSF eosinophilia. These findings indicate that A. cantonensis infection in the mouse causes IL-5 production and subsequent CSF eosinophilia, the latter probably being involved in the killing of intracranial worms.

Authors+Show Affiliations

Department of Parasitology, Akita University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9211511

Citation

Sugaya, H, et al. "Eosinophilia and Intracranial Worm Recovery in Interleukin-5 Transgenic and Interleukin-5 Receptor Alpha Chain-knockout Mice Infected With Angiostrongylus Cantonensis." Parasitology Research, vol. 83, no. 6, 1997, pp. 583-90.
Sugaya H, Aoki M, Yoshida T, et al. Eosinophilia and intracranial worm recovery in interleukin-5 transgenic and interleukin-5 receptor alpha chain-knockout mice infected with Angiostrongylus cantonensis. Parasitol Res. 1997;83(6):583-90.
Sugaya, H., Aoki, M., Yoshida, T., Takatsu, K., & Yoshimura, K. (1997). Eosinophilia and intracranial worm recovery in interleukin-5 transgenic and interleukin-5 receptor alpha chain-knockout mice infected with Angiostrongylus cantonensis. Parasitology Research, 83(6), 583-90.
Sugaya H, et al. Eosinophilia and Intracranial Worm Recovery in Interleukin-5 Transgenic and Interleukin-5 Receptor Alpha Chain-knockout Mice Infected With Angiostrongylus Cantonensis. Parasitol Res. 1997;83(6):583-90. PubMed PMID: 9211511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eosinophilia and intracranial worm recovery in interleukin-5 transgenic and interleukin-5 receptor alpha chain-knockout mice infected with Angiostrongylus cantonensis. AU - Sugaya,H, AU - Aoki,M, AU - Yoshida,T, AU - Takatsu,K, AU - Yoshimura,K, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 583 EP - 90 JF - Parasitology research JO - Parasitol Res VL - 83 IS - 6 N2 - We infected interleukin-5 (IL-5)-transgenic (IL-5-Tg) and IL-5 receptor alpha knockout (IL-5R alpha -/-) mice with Angiostrongylus cantonensis to determine the possible roles of IL-5 and eosinophils in A. cantonensis infection in mice. IL-5-Tg mice demonstrated significantly higher eosinophilia in bone marrow, blood and cerebrospinal fluid (CSF), lower intracranial worm recovery and smaller female worms than naive C3H/HeN mice. Both IL-5-Tg and C3H/HeN mice evoked antigen-specific serum and CSF IgA antibody responses as early as days 5 and 7 postinfection, respectively. Prominent eosinophil infiltration was noted around intracranial worms in the subarachnoid spaces of the mouse brains; eosinophils adhering to the worm surface were degranulated. In contrast, IL-5R alpha -/- mice yielded a higher worm recovery than wild-type or heterozygous mice at day 20 postinfection and failed to provoke CSF eosinophilia. These findings indicate that A. cantonensis infection in the mouse causes IL-5 production and subsequent CSF eosinophilia, the latter probably being involved in the killing of intracranial worms. SN - 0932-0113 UR - https://www.unboundmedicine.com/medline/citation/9211511/Eosinophilia_and_intracranial_worm_recovery_in_interleukin_5_transgenic_and_interleukin_5_receptor_alpha_chain_knockout_mice_infected_with_Angiostrongylus_cantonensis_ L2 - https://dx.doi.org/10.1007/s004360050302 DB - PRIME DP - Unbound Medicine ER -