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Pharmacokinetics and tissue localization of antisense oligonucleotides in balloon-injured pig coronary arteries after local delivery with an iontophoretic balloon catheter.
Cathet Cardiovasc Diagn. 1997 Jul; 41(3):354-9.CC

Abstract

When delivered locally to the arterial wall by passive fluid transfer systems such as perforated balloons, water-soluble compounds in aqueous solution are not readily taken up by tissue, show low levels of cellular localization, and are quickly lost by wash-out. One approach to improve delivery is addition of an "active" component to the catheter system to change the nature of the drug-to-tissue interaction. Using an iontophoretic balloon catheter to deliver antisense oligonucleotide (ODN) to pig coronary arteries after balloon angioplasty, we determined the quantity and localization of ODN in the tissue. By radiolabeling, 7.3 +/- 2.4 micrograms ODN was present at 30 min, 1.5 +/- 0.6 at 2 h, 0.52 +/- 0.35 at 24 h, and 0.26 +/- 0.11 at 7 d. By fluorescent labeling, circumferential medial uptake and adventitial delivery at the site of medial injury was observed, with primarily cellular localization. The iontophoretic catheter thus appears to be a useful device for ODN delivery to arterial tissue.

Authors+Show Affiliations

Andreas Gruentzig Cardiovascular Center, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA. keith_robinson@email.eusch.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9213036

Citation

Robinson, K A., et al. "Pharmacokinetics and Tissue Localization of Antisense Oligonucleotides in Balloon-injured Pig Coronary Arteries After Local Delivery With an Iontophoretic Balloon Catheter." Catheterization and Cardiovascular Diagnosis, vol. 41, no. 3, 1997, pp. 354-9.
Robinson KA, Chronos NA, Schieffer E, et al. Pharmacokinetics and tissue localization of antisense oligonucleotides in balloon-injured pig coronary arteries after local delivery with an iontophoretic balloon catheter. Cathet Cardiovasc Diagn. 1997;41(3):354-9.
Robinson, K. A., Chronos, N. A., Schieffer, E., Palmer, S. J., Cipolla, G. D., Milner, P. G., Walsh, R. G., & King, S. B. (1997). Pharmacokinetics and tissue localization of antisense oligonucleotides in balloon-injured pig coronary arteries after local delivery with an iontophoretic balloon catheter. Catheterization and Cardiovascular Diagnosis, 41(3), 354-9.
Robinson KA, et al. Pharmacokinetics and Tissue Localization of Antisense Oligonucleotides in Balloon-injured Pig Coronary Arteries After Local Delivery With an Iontophoretic Balloon Catheter. Cathet Cardiovasc Diagn. 1997;41(3):354-9. PubMed PMID: 9213036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics and tissue localization of antisense oligonucleotides in balloon-injured pig coronary arteries after local delivery with an iontophoretic balloon catheter. AU - Robinson,K A, AU - Chronos,N A, AU - Schieffer,E, AU - Palmer,S J, AU - Cipolla,G D, AU - Milner,P G, AU - Walsh,R G, AU - King,S B,3rd PY - 1997/7/1/pubmed PY - 2000/6/20/medline PY - 1997/7/1/entrez SP - 354 EP - 9 JF - Catheterization and cardiovascular diagnosis JO - Cathet Cardiovasc Diagn VL - 41 IS - 3 N2 - When delivered locally to the arterial wall by passive fluid transfer systems such as perforated balloons, water-soluble compounds in aqueous solution are not readily taken up by tissue, show low levels of cellular localization, and are quickly lost by wash-out. One approach to improve delivery is addition of an "active" component to the catheter system to change the nature of the drug-to-tissue interaction. Using an iontophoretic balloon catheter to deliver antisense oligonucleotide (ODN) to pig coronary arteries after balloon angioplasty, we determined the quantity and localization of ODN in the tissue. By radiolabeling, 7.3 +/- 2.4 micrograms ODN was present at 30 min, 1.5 +/- 0.6 at 2 h, 0.52 +/- 0.35 at 24 h, and 0.26 +/- 0.11 at 7 d. By fluorescent labeling, circumferential medial uptake and adventitial delivery at the site of medial injury was observed, with primarily cellular localization. The iontophoretic catheter thus appears to be a useful device for ODN delivery to arterial tissue. SN - 0098-6569 UR - https://www.unboundmedicine.com/medline/citation/9213036/Pharmacokinetics_and_tissue_localization_of_antisense_oligonucleotides_in_balloon_injured_pig_coronary_arteries_after_local_delivery_with_an_iontophoretic_balloon_catheter_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0098-6569&date=1997&volume=41&issue=3&spage=354 DB - PRIME DP - Unbound Medicine ER -