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Delta9-THC as a discriminative cue in pigeons: effects of delta8-THC, CBD, and CBN.
Arch Int Pharmacodyn Ther. 1977 Jul; 228(1):68-72.AI

Abstract

Pigeons, trained to discriminate the effects of i.m. injections of delta9-tetrahydrocannabinol (delta9-THC, 0.25 mg/kg) from the effects of the vehicle in a drug discrimination paradigm, were tested for generalization with the isomeric delta8-THC, cannabidiol (CBD) and cannabinol (CBN). When given in sufficient doses, delta8-THC and CBN were found to substitute for delta9-THC whereas CBD did not. CBD and CBN did not antagonize the stimulus effect of delta9-THC. The combination of CBN and delta9-THC rather appeared to accentuate the drug response.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

921403

Citation

Järbe, T U., et al. "Delta9-THC as a Discriminative Cue in Pigeons: Effects of delta8-THC, CBD, and CBN." Archives Internationales De Pharmacodynamie Et De Therapie, vol. 228, no. 1, 1977, pp. 68-72.
Järbe TU, Henriksson BG, Ohlin GC. Delta9-THC as a discriminative cue in pigeons: effects of delta8-THC, CBD, and CBN. Arch Int Pharmacodyn Ther. 1977;228(1):68-72.
Järbe, T. U., Henriksson, B. G., & Ohlin, G. C. (1977). Delta9-THC as a discriminative cue in pigeons: effects of delta8-THC, CBD, and CBN. Archives Internationales De Pharmacodynamie Et De Therapie, 228(1), 68-72.
Järbe TU, Henriksson BG, Ohlin GC. Delta9-THC as a Discriminative Cue in Pigeons: Effects of delta8-THC, CBD, and CBN. Arch Int Pharmacodyn Ther. 1977;228(1):68-72. PubMed PMID: 921403.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Delta9-THC as a discriminative cue in pigeons: effects of delta8-THC, CBD, and CBN. AU - Järbe,T U, AU - Henriksson,B G, AU - Ohlin,G C, PY - 1977/7/1/pubmed PY - 1977/7/1/medline PY - 1977/7/1/entrez SP - 68 EP - 72 JF - Archives internationales de pharmacodynamie et de therapie JO - Arch Int Pharmacodyn Ther VL - 228 IS - 1 N2 - Pigeons, trained to discriminate the effects of i.m. injections of delta9-tetrahydrocannabinol (delta9-THC, 0.25 mg/kg) from the effects of the vehicle in a drug discrimination paradigm, were tested for generalization with the isomeric delta8-THC, cannabidiol (CBD) and cannabinol (CBN). When given in sufficient doses, delta8-THC and CBN were found to substitute for delta9-THC whereas CBD did not. CBD and CBN did not antagonize the stimulus effect of delta9-THC. The combination of CBN and delta9-THC rather appeared to accentuate the drug response. SN - 0003-9780 UR - https://www.unboundmedicine.com/medline/citation/921403/Delta9_THC_as_a_discriminative_cue_in_pigeons:_effects_of_delta8_THC_CBD_and_CBN_ DB - PRIME DP - Unbound Medicine ER -