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Normal recovery of the stratum corneum barrier function following damage induced by tape stripping in patients with atopic dermatitis.
Br J Dermatol. 1997 Jun; 136(6):966-7.BJ

Abstract

Patients with atopic dermatitis (AD) constantly inflict mechanical damage to their skin by scratching induced by pruritus. On excoriated lesions of the cheek we found exceedingly high levels of transepidermal water loss (TEWL) as compared to those in the normal skin of healthy subjects. However, it is not clear whether the skin of patients with AD also shows an abnormally slow recovery after mechanical damage. We compared the recovery of the barrier function of the stratum corneum (SC), after its complete removal by tape stripping, in patients with AD and age-matched healthy control subjects. On the normal-looking skin of the flexor forearm, we found no difference in the recovery process of the water barrier function of the SC between the two groups. This suggests that ability to reconstruct SC barrier function after mechanical damage is not impaired in AD patients.

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Authors+Show Affiliations

Tanaka M
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Zhen YX
No affiliation info available
Tagami H
No affiliation info available

MeSH

AdultCell Membrane PermeabilityDermatitis, AtopicEpidermisFaceFemaleHumansMaleWater Loss, InsensibleWound Healing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9217838

Citation

Tanaka, M, et al. "Normal Recovery of the Stratum Corneum Barrier Function Following Damage Induced By Tape Stripping in Patients With Atopic Dermatitis." The British Journal of Dermatology, vol. 136, no. 6, 1997, pp. 966-7.
Tanaka M, Zhen YX, Tagami H. Normal recovery of the stratum corneum barrier function following damage induced by tape stripping in patients with atopic dermatitis. Br J Dermatol. 1997;136(6):966-7.
Tanaka, M., Zhen, Y. X., & Tagami, H. (1997). Normal recovery of the stratum corneum barrier function following damage induced by tape stripping in patients with atopic dermatitis. The British Journal of Dermatology, 136(6), 966-7.
Tanaka M, Zhen YX, Tagami H. Normal Recovery of the Stratum Corneum Barrier Function Following Damage Induced By Tape Stripping in Patients With Atopic Dermatitis. Br J Dermatol. 1997;136(6):966-7. PubMed PMID: 9217838.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Normal recovery of the stratum corneum barrier function following damage induced by tape stripping in patients with atopic dermatitis. AU - Tanaka,M, AU - Zhen,Y X, AU - Tagami,H, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 966 EP - 7 JF - The British journal of dermatology JO - Br J Dermatol VL - 136 IS - 6 N2 - Patients with atopic dermatitis (AD) constantly inflict mechanical damage to their skin by scratching induced by pruritus. On excoriated lesions of the cheek we found exceedingly high levels of transepidermal water loss (TEWL) as compared to those in the normal skin of healthy subjects. However, it is not clear whether the skin of patients with AD also shows an abnormally slow recovery after mechanical damage. We compared the recovery of the barrier function of the stratum corneum (SC), after its complete removal by tape stripping, in patients with AD and age-matched healthy control subjects. On the normal-looking skin of the flexor forearm, we found no difference in the recovery process of the water barrier function of the SC between the two groups. This suggests that ability to reconstruct SC barrier function after mechanical damage is not impaired in AD patients. SN - 0007-0963 UR - https://www.unboundmedicine.com/medline/citation/9217838/Normal_recovery_of_the_stratum_corneum_barrier_function_following_damage_induced_by_tape_stripping_in_patients_with_atopic_dermatitis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1997&volume=136&issue=6&spage=966 DB - PRIME DP - Unbound Medicine ER -