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The effect of decaffeination of coffee on gastro-oesophageal reflux in patients with reflux disease.
Aliment Pharmacol Ther 1997; 11(3):483-6AP

Abstract

BACKGROUND

Patients with reflux disease often complain of heartburn after ingestion of coffee. Induction of gastro-oesophageal reflux has been demonstrated by pH-metry following the intake of coffee in healthy volunteers. The reflux was reduced when the coffee had undergone a decaffeination process. The aim of this study was to investigate the effect of decaffeination of coffee on reflux in patients with reflux disease.

METHODS

Seventeen reflux patients underwent two osesophageal 3-h pH measurements. The patients received, in a double-blind study design in a randomized order, 300 mL of either regular or decaffeinated coffee together with a standardized breakfast. The fraction time oesophageal pH < 4 was calculated during the three postprandial hours.

RESULTS

For regular coffee the fraction time was calculated to a median of 17.9% with a range of 0.7-56.6%. The fraction time was significantly reduced to 3.1% (0-49.9%) after ingestion of decaffeinated coffee.

CONCLUSION

The amount of gastro-oesophageal reflux induced by the intake of regular coffee in patients with reflux disease can be reduce by the decaffeination of coffee.

Authors+Show Affiliations

Department of Gastroenterology, Hospital Bogenhausen, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9218070

Citation

Pehl, C, et al. "The Effect of Decaffeination of Coffee On Gastro-oesophageal Reflux in Patients With Reflux Disease." Alimentary Pharmacology & Therapeutics, vol. 11, no. 3, 1997, pp. 483-6.
Pehl C, Pfeiffer A, Wendl B, et al. The effect of decaffeination of coffee on gastro-oesophageal reflux in patients with reflux disease. Aliment Pharmacol Ther. 1997;11(3):483-6.
Pehl, C., Pfeiffer, A., Wendl, B., & Kaess, H. (1997). The effect of decaffeination of coffee on gastro-oesophageal reflux in patients with reflux disease. Alimentary Pharmacology & Therapeutics, 11(3), pp. 483-6.
Pehl C, et al. The Effect of Decaffeination of Coffee On Gastro-oesophageal Reflux in Patients With Reflux Disease. Aliment Pharmacol Ther. 1997;11(3):483-6. PubMed PMID: 9218070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of decaffeination of coffee on gastro-oesophageal reflux in patients with reflux disease. AU - Pehl,C, AU - Pfeiffer,A, AU - Wendl,B, AU - Kaess,H, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 483 EP - 6 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 11 IS - 3 N2 - BACKGROUND: Patients with reflux disease often complain of heartburn after ingestion of coffee. Induction of gastro-oesophageal reflux has been demonstrated by pH-metry following the intake of coffee in healthy volunteers. The reflux was reduced when the coffee had undergone a decaffeination process. The aim of this study was to investigate the effect of decaffeination of coffee on reflux in patients with reflux disease. METHODS: Seventeen reflux patients underwent two osesophageal 3-h pH measurements. The patients received, in a double-blind study design in a randomized order, 300 mL of either regular or decaffeinated coffee together with a standardized breakfast. The fraction time oesophageal pH < 4 was calculated during the three postprandial hours. RESULTS: For regular coffee the fraction time was calculated to a median of 17.9% with a range of 0.7-56.6%. The fraction time was significantly reduced to 3.1% (0-49.9%) after ingestion of decaffeinated coffee. CONCLUSION: The amount of gastro-oesophageal reflux induced by the intake of regular coffee in patients with reflux disease can be reduce by the decaffeination of coffee. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/9218070/full_citation L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0269-2813&amp;date=1997&amp;volume=11&amp;issue=3&amp;spage=483 DB - PRIME DP - Unbound Medicine ER -