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Influence of hepatitis C virus genotypes and HIV infection on histological severity of chronic hepatitis C. The Hepatitis/HIV Spanish Study Group.
Am J Gastroenterol. 1997 Jul; 92(7):1130-4.AJ

Abstract

OBJECTIVES

The factors influencing the histological severity of chronic hepatitis C (CHC) have not been well established. We therefore investigated the effect of hepatitis C virus (HCV) genotypes and human immunodeficiency virus (HIV) infection on histological liver damage in a cohort of intravenous drug users with CHC.

METHODS

We analyzed the histological activity score and the HCV genotypes in 59 HCV-RNA-positive patients with biopsy-proven CHC. Forty-eight (81%) of them had concomitant HIV infection with a CD4+ cell count above 200 x 10(6) cells/L and an absence of AIDS-defining conditions. Multivariate analysis was performed to determine the features associated with the histological severity.

RESULTS

Minimal/mild hepatitis was found in 16 patients (27%), moderate chronic hepatitis in 29 (49%), and severe chronic hepatitis in 14 (24%). Patients with HCV subtype 1b had a higher histological score than others (8.7 +/- 3.3 vs. 6.5 +/- 3.2, p = 0.012), either as single or mixed infections. In multivariate analysis, HIV-infected individuals had a higher score of piecemeal necrosis (OR = 21.7, p = 0.002) and a higher stage of fibrosis (OR = 17.9, p = 0.004) than patients without HIV infection. HIV infection and HCV genotype 1b were found to be independent factors of histological severity.

CONCLUSIONS

Liver damage in patients with CHC seems to be directly influenced by HCV subtypes. Infection by HCV subtype 1b is closely associated with more severe forms of liver pathology. Furthermore, the presence of HIV infection is an independent factor associated with more aggressive histological damage. In these patients, higher degrees of piecemeal necrosis and fibrosis are commonly seen.

Authors+Show Affiliations

Centro Nacional de Epidemiología, Instítuto de Salud Carlos III, and Hospital Ramón y Cajal, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

9219784

Citation

García-Samaniego, J, et al. "Influence of Hepatitis C Virus Genotypes and HIV Infection On Histological Severity of Chronic Hepatitis C. the Hepatitis/HIV Spanish Study Group." The American Journal of Gastroenterology, vol. 92, no. 7, 1997, pp. 1130-4.
García-Samaniego J, Soriano V, Castilla J, et al. Influence of hepatitis C virus genotypes and HIV infection on histological severity of chronic hepatitis C. The Hepatitis/HIV Spanish Study Group. Am J Gastroenterol. 1997;92(7):1130-4.
García-Samaniego, J., Soriano, V., Castilla, J., Bravo, R., Moreno, A., Carbó, J., Iñiguez, A., González, J., & Muñoz, F. (1997). Influence of hepatitis C virus genotypes and HIV infection on histological severity of chronic hepatitis C. The Hepatitis/HIV Spanish Study Group. The American Journal of Gastroenterology, 92(7), 1130-4.
García-Samaniego J, et al. Influence of Hepatitis C Virus Genotypes and HIV Infection On Histological Severity of Chronic Hepatitis C. the Hepatitis/HIV Spanish Study Group. Am J Gastroenterol. 1997;92(7):1130-4. PubMed PMID: 9219784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of hepatitis C virus genotypes and HIV infection on histological severity of chronic hepatitis C. The Hepatitis/HIV Spanish Study Group. AU - García-Samaniego,J, AU - Soriano,V, AU - Castilla,J, AU - Bravo,R, AU - Moreno,A, AU - Carbó,J, AU - Iñiguez,A, AU - González,J, AU - Muñoz,F, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 1130 EP - 4 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 92 IS - 7 N2 - OBJECTIVES: The factors influencing the histological severity of chronic hepatitis C (CHC) have not been well established. We therefore investigated the effect of hepatitis C virus (HCV) genotypes and human immunodeficiency virus (HIV) infection on histological liver damage in a cohort of intravenous drug users with CHC. METHODS: We analyzed the histological activity score and the HCV genotypes in 59 HCV-RNA-positive patients with biopsy-proven CHC. Forty-eight (81%) of them had concomitant HIV infection with a CD4+ cell count above 200 x 10(6) cells/L and an absence of AIDS-defining conditions. Multivariate analysis was performed to determine the features associated with the histological severity. RESULTS: Minimal/mild hepatitis was found in 16 patients (27%), moderate chronic hepatitis in 29 (49%), and severe chronic hepatitis in 14 (24%). Patients with HCV subtype 1b had a higher histological score than others (8.7 +/- 3.3 vs. 6.5 +/- 3.2, p = 0.012), either as single or mixed infections. In multivariate analysis, HIV-infected individuals had a higher score of piecemeal necrosis (OR = 21.7, p = 0.002) and a higher stage of fibrosis (OR = 17.9, p = 0.004) than patients without HIV infection. HIV infection and HCV genotype 1b were found to be independent factors of histological severity. CONCLUSIONS: Liver damage in patients with CHC seems to be directly influenced by HCV subtypes. Infection by HCV subtype 1b is closely associated with more severe forms of liver pathology. Furthermore, the presence of HIV infection is an independent factor associated with more aggressive histological damage. In these patients, higher degrees of piecemeal necrosis and fibrosis are commonly seen. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/9219784/Influence_of_hepatitis_C_virus_genotypes_and_HIV_infection_on_histological_severity_of_chronic_hepatitis_C__The_Hepatitis/HIV_Spanish_Study_Group_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -