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Genetic association between susceptibility to Parkinson's disease and alpha1-antichymotrypsin polymorphism.
Brain Res. 1997 Jun 06; 759(1):153-5.BR

Abstract

The apolipoprotein E (ApoE*) gene is a major risk factor of developing Alzheimer's disease (AD) and the alpha1-antichymotrypsin (ACT) polymorphism is likely to modify susceptibility of the ApoE* gene for AD. Because pathogenesis of AD is partly similar to that in idiopathic Parkinson's disease (PD), we investigated the distribution of genotypes of the ApoE and the ACT in patients with PD. The number of individuals with two copies of the ACT-A allele (ACT-AA genotype) in patients with PD increased significantly compared to that in healthy controls (19.9% versus 8.3%, P < 0.02), and the ACT-A allele frequency in patients with PD was significantly higher than that in healthy controls (chi2 = 5.96, df = 1, P < 0.015). The odds ratio for developing PD in individuals with the ACT-AA genotype was 3.36 compared to individuals with two copies of another allele, the ACT-T allele (ACT-TT genotype). There was no association between ApoE genotypes and susceptibility to PD. These data suggest that the etiological basis of PD might be partly similar to that of AD and the ACT gene might be one of the susceptibility factors for PD.

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Authors+Show Affiliations

Yamamoto M
Department of Neurology, Kagawa Prefectural Central Hospital, Takamatsu, Japan. dryama@mall.netwave.or.jp
Kondo I
No affiliation info available
Ogawa N
No affiliation info available
Asanuma M
No affiliation info available
Yamashita Y
No affiliation info available
Mizuno Y
No affiliation info available

MeSH

AdultAgedAged, 80 and overAllelesApolipoproteins EFemaleGene DosageGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedParkinson DiseasePolymorphism, Geneticalpha 1-Antichymotrypsin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9219874

Citation

Yamamoto, M, et al. "Genetic Association Between Susceptibility to Parkinson's Disease and Alpha1-antichymotrypsin Polymorphism." Brain Research, vol. 759, no. 1, 1997, pp. 153-5.
Yamamoto M, Kondo I, Ogawa N, et al. Genetic association between susceptibility to Parkinson's disease and alpha1-antichymotrypsin polymorphism. Brain Res. 1997;759(1):153-5.
Yamamoto, M., Kondo, I., Ogawa, N., Asanuma, M., Yamashita, Y., & Mizuno, Y. (1997). Genetic association between susceptibility to Parkinson's disease and alpha1-antichymotrypsin polymorphism. Brain Research, 759(1), 153-5.
Yamamoto M, et al. Genetic Association Between Susceptibility to Parkinson's Disease and Alpha1-antichymotrypsin Polymorphism. Brain Res. 1997 Jun 6;759(1):153-5. PubMed PMID: 9219874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic association between susceptibility to Parkinson's disease and alpha1-antichymotrypsin polymorphism. AU - Yamamoto,M, AU - Kondo,I, AU - Ogawa,N, AU - Asanuma,M, AU - Yamashita,Y, AU - Mizuno,Y, PY - 1997/6/6/pubmed PY - 1997/6/6/medline PY - 1997/6/6/entrez SP - 153 EP - 5 JF - Brain research JO - Brain Res VL - 759 IS - 1 N2 - The apolipoprotein E (ApoE*) gene is a major risk factor of developing Alzheimer's disease (AD) and the alpha1-antichymotrypsin (ACT) polymorphism is likely to modify susceptibility of the ApoE* gene for AD. Because pathogenesis of AD is partly similar to that in idiopathic Parkinson's disease (PD), we investigated the distribution of genotypes of the ApoE and the ACT in patients with PD. The number of individuals with two copies of the ACT-A allele (ACT-AA genotype) in patients with PD increased significantly compared to that in healthy controls (19.9% versus 8.3%, P < 0.02), and the ACT-A allele frequency in patients with PD was significantly higher than that in healthy controls (chi2 = 5.96, df = 1, P < 0.015). The odds ratio for developing PD in individuals with the ACT-AA genotype was 3.36 compared to individuals with two copies of another allele, the ACT-T allele (ACT-TT genotype). There was no association between ApoE genotypes and susceptibility to PD. These data suggest that the etiological basis of PD might be partly similar to that of AD and the ACT gene might be one of the susceptibility factors for PD. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/9219874/Genetic_association_between_susceptibility_to_Parkinson's_disease_and_alpha1_antichymotrypsin_polymorphism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-8993(97)00330-2 DB - PRIME DP - Unbound Medicine ER -