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High-dose medroxyprogesterone acetate for the treatment of dysfunctional uterine bleeding in 24 adolescents.
Aust N Z J Obstet Gynaecol 1997; 37(2):228-31AN

Abstract

The objective of the study was to evaluate the effectiveness of high-dose oral medroxyprogesterone acetate therapy in the management of excessive dysfunctional uterine bleeding in adolescents. The study group consisted of 24 adolescents who were hospitalized with the diagnosis of excessive uterine bleeding and anaemia. Oral medroxyprogesterone acetate tablets were administered at a total dose of 60-120 mg during the first day of admission and 20 mg per day for the following 10 days. The blood loss was reduced to acceptable levels in all patients, and actually stopped in 6 (25%) within the first 24 hours of the treatment; bleeding ceased in 29.2%, 20.8% and 25% on the second, third and fourth days respectively. Significant correlation was identified between the initial haemoglobin concentration and the time required for cessation of bleeding (r2 = 0.5, p = 0.001). Rapid saturation of the endometrium with progestogens seems to be an highly effective mode of treatment for excessive dysfunctional uterine bleeding in adolescents.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Cerrahpaşa Medical Faculty, University of Istanbul, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9222474

Citation

Aksu, F, et al. "High-dose Medroxyprogesterone Acetate for the Treatment of Dysfunctional Uterine Bleeding in 24 Adolescents." The Australian & New Zealand Journal of Obstetrics & Gynaecology, vol. 37, no. 2, 1997, pp. 228-31.
Aksu F, Madazli R, Budak E, et al. High-dose medroxyprogesterone acetate for the treatment of dysfunctional uterine bleeding in 24 adolescents. Aust N Z J Obstet Gynaecol. 1997;37(2):228-31.
Aksu, F., Madazli, R., Budak, E., Cepni, I., & Benian, A. (1997). High-dose medroxyprogesterone acetate for the treatment of dysfunctional uterine bleeding in 24 adolescents. The Australian & New Zealand Journal of Obstetrics & Gynaecology, 37(2), pp. 228-31.
Aksu F, et al. High-dose Medroxyprogesterone Acetate for the Treatment of Dysfunctional Uterine Bleeding in 24 Adolescents. Aust N Z J Obstet Gynaecol. 1997;37(2):228-31. PubMed PMID: 9222474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-dose medroxyprogesterone acetate for the treatment of dysfunctional uterine bleeding in 24 adolescents. AU - Aksu,F, AU - Madazli,R, AU - Budak,E, AU - Cepni,I, AU - Benian,A, PY - 1997/5/1/pubmed PY - 1997/5/1/medline PY - 1997/5/1/entrez SP - 228 EP - 31 JF - The Australian & New Zealand journal of obstetrics & gynaecology JO - Aust N Z J Obstet Gynaecol VL - 37 IS - 2 N2 - The objective of the study was to evaluate the effectiveness of high-dose oral medroxyprogesterone acetate therapy in the management of excessive dysfunctional uterine bleeding in adolescents. The study group consisted of 24 adolescents who were hospitalized with the diagnosis of excessive uterine bleeding and anaemia. Oral medroxyprogesterone acetate tablets were administered at a total dose of 60-120 mg during the first day of admission and 20 mg per day for the following 10 days. The blood loss was reduced to acceptable levels in all patients, and actually stopped in 6 (25%) within the first 24 hours of the treatment; bleeding ceased in 29.2%, 20.8% and 25% on the second, third and fourth days respectively. Significant correlation was identified between the initial haemoglobin concentration and the time required for cessation of bleeding (r2 = 0.5, p = 0.001). Rapid saturation of the endometrium with progestogens seems to be an highly effective mode of treatment for excessive dysfunctional uterine bleeding in adolescents. SN - 0004-8666 UR - https://www.unboundmedicine.com/medline/citation/9222474/High_dose_medroxyprogesterone_acetate_for_the_treatment_of_dysfunctional_uterine_bleeding_in_24_adolescents_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0004-8666&date=1997&volume=37&issue=2&spage=228 DB - PRIME DP - Unbound Medicine ER -