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The histamine H1-antagonist chlorpheniramine facilitates learning in aged rats.
Neurosci Lett. 1997 Jun 27; 229(2):89-92.NL

Abstract

The effect of the histamine H1-receptor antagonist chlorpheniramine on inhibitory avoidance conditioning was investigated in 31-month-old rats, using a one-trial step-through avoidance task. Immediately after the learning trial, old rats were injected intraperitoneally with 5 or 10 mg/kg d-chlorpheniramine. Control groups included vehicle-injected old and adult (4-month-old) rats and a group of aged animals given an injection of 10 mg/kg chlorpheniramine 5 h after the training trial. When tested 24 h after training, aged rats receiving 10 mg/kg chlorpheniramine exhibited longer step-through latencies than vehicle-treated old controls, indicative of superior learning of the task. The hypermnestic effects of 10 mg/kg chlorpheniramine were no longer evident when injection was performed 5 h, rather than immediately after the learning trial, ruling out enduring proactive effects of the treatment on test performance. Furthermore, vehicle-treated old rats showed poorer inhibitory avoidance performance than vehicle-treated adult controls. Thus, the improvement in performance after the 10 mg/kg dose of chlorpheniramine can be interpreted in terms of a compensation of performance deficits in the old rats.

Authors+Show Affiliations

Institute of Physiological Psychology and Center for Biological and Medical Research, Heinrich-Heine-University of Düsseldorf, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9223598

Citation

Frisch, C, et al. "The Histamine H1-antagonist Chlorpheniramine Facilitates Learning in Aged Rats." Neuroscience Letters, vol. 229, no. 2, 1997, pp. 89-92.
Frisch C, Hasenöhrl RU, Huston JP. The histamine H1-antagonist chlorpheniramine facilitates learning in aged rats. Neurosci Lett. 1997;229(2):89-92.
Frisch, C., Hasenöhrl, R. U., & Huston, J. P. (1997). The histamine H1-antagonist chlorpheniramine facilitates learning in aged rats. Neuroscience Letters, 229(2), 89-92.
Frisch C, Hasenöhrl RU, Huston JP. The Histamine H1-antagonist Chlorpheniramine Facilitates Learning in Aged Rats. Neurosci Lett. 1997 Jun 27;229(2):89-92. PubMed PMID: 9223598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The histamine H1-antagonist chlorpheniramine facilitates learning in aged rats. AU - Frisch,C, AU - Hasenöhrl,R U, AU - Huston,J P, PY - 1997/6/27/pubmed PY - 1997/6/27/medline PY - 1997/6/27/entrez SP - 89 EP - 92 JF - Neuroscience letters JO - Neurosci Lett VL - 229 IS - 2 N2 - The effect of the histamine H1-receptor antagonist chlorpheniramine on inhibitory avoidance conditioning was investigated in 31-month-old rats, using a one-trial step-through avoidance task. Immediately after the learning trial, old rats were injected intraperitoneally with 5 or 10 mg/kg d-chlorpheniramine. Control groups included vehicle-injected old and adult (4-month-old) rats and a group of aged animals given an injection of 10 mg/kg chlorpheniramine 5 h after the training trial. When tested 24 h after training, aged rats receiving 10 mg/kg chlorpheniramine exhibited longer step-through latencies than vehicle-treated old controls, indicative of superior learning of the task. The hypermnestic effects of 10 mg/kg chlorpheniramine were no longer evident when injection was performed 5 h, rather than immediately after the learning trial, ruling out enduring proactive effects of the treatment on test performance. Furthermore, vehicle-treated old rats showed poorer inhibitory avoidance performance than vehicle-treated adult controls. Thus, the improvement in performance after the 10 mg/kg dose of chlorpheniramine can be interpreted in terms of a compensation of performance deficits in the old rats. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/9223598/The_histamine_H1_antagonist_chlorpheniramine_facilitates_learning_in_aged_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304394097004229 DB - PRIME DP - Unbound Medicine ER -