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Gout and risk for subsequent coronary heart disease. The Meharry-Hopkins Study.
Arch Intern Med. 1997 Jul 14; 157(13):1436-40.AI

Abstract

BACKGROUND

Patients with gout are encountered frequently in clinical practice. Previous studies have suggested that hyperuricemia and gout may represent risk factors for coronary heart disease (CHD), the most common cause of death in American men.

METHODS

Prospectively collected data from 2 longitudinal cohort studies of former medical students--371 black men in the Meharry Cohort Study and 1181 white men in the Johns Hopkins Precursors Study--were analyzed. The development of gout and of CHD was determined by physician self-report, and validated by using published criteria. The risk for CHD associated with gout was evaluated using Cox proportional hazards analysis.

RESULTS

During a median follow-up of 30 years, there were 38 gout cases and 44 CHD events among the Meharry men, and 68 gout cases and 138 CHD events among the Hopkins men. Prior gout was not associated with an increased risk for incident CHD (relative risk = 1.20; 95% confidence interval, 0.37-3.92) among the Meharry men or among the Hopkins men (relative risk = 0.66; 95% confidence interval, 0.24-1.79). Multivariate analysis adjusted for known CHD risk factors did not alter these findings.

CONCLUSION

These results, in black and white male physicians, do not suggest a role in men for targeting gout identification in the primary prevention of CHD.

Authors+Show Affiliations

Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA. agelber@welchlink.welch.jhu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9224221

Citation

Gelber, A C., et al. "Gout and Risk for Subsequent Coronary Heart Disease. the Meharry-Hopkins Study." Archives of Internal Medicine, vol. 157, no. 13, 1997, pp. 1436-40.
Gelber AC, Klag MJ, Mead LA, et al. Gout and risk for subsequent coronary heart disease. The Meharry-Hopkins Study. Arch Intern Med. 1997;157(13):1436-40.
Gelber, A. C., Klag, M. J., Mead, L. A., Thomas, J., Thomas, D. J., Pearson, T. A., & Hochberg, M. C. (1997). Gout and risk for subsequent coronary heart disease. The Meharry-Hopkins Study. Archives of Internal Medicine, 157(13), 1436-40.
Gelber AC, et al. Gout and Risk for Subsequent Coronary Heart Disease. the Meharry-Hopkins Study. Arch Intern Med. 1997 Jul 14;157(13):1436-40. PubMed PMID: 9224221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gout and risk for subsequent coronary heart disease. The Meharry-Hopkins Study. AU - Gelber,A C, AU - Klag,M J, AU - Mead,L A, AU - Thomas,J, AU - Thomas,D J, AU - Pearson,T A, AU - Hochberg,M C, PY - 1997/7/14/pubmed PY - 1997/7/14/medline PY - 1997/7/14/entrez SP - 1436 EP - 40 JF - Archives of internal medicine JO - Arch Intern Med VL - 157 IS - 13 N2 - BACKGROUND: Patients with gout are encountered frequently in clinical practice. Previous studies have suggested that hyperuricemia and gout may represent risk factors for coronary heart disease (CHD), the most common cause of death in American men. METHODS: Prospectively collected data from 2 longitudinal cohort studies of former medical students--371 black men in the Meharry Cohort Study and 1181 white men in the Johns Hopkins Precursors Study--were analyzed. The development of gout and of CHD was determined by physician self-report, and validated by using published criteria. The risk for CHD associated with gout was evaluated using Cox proportional hazards analysis. RESULTS: During a median follow-up of 30 years, there were 38 gout cases and 44 CHD events among the Meharry men, and 68 gout cases and 138 CHD events among the Hopkins men. Prior gout was not associated with an increased risk for incident CHD (relative risk = 1.20; 95% confidence interval, 0.37-3.92) among the Meharry men or among the Hopkins men (relative risk = 0.66; 95% confidence interval, 0.24-1.79). Multivariate analysis adjusted for known CHD risk factors did not alter these findings. CONCLUSION: These results, in black and white male physicians, do not suggest a role in men for targeting gout identification in the primary prevention of CHD. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/9224221/Gout_and_risk_for_subsequent_coronary_heart_disease__The_Meharry_Hopkins_Study_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/157/pg/1436 DB - PRIME DP - Unbound Medicine ER -