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Serum immunoglobulins and the risk of rheumatoid arthritis.
Ann Rheum Dis. 1997 Jun; 56(6):351-6.AR

Abstract

OBJECTIVE

Rheumatoid arthritis (RA) is associated with several autoantibodies that can precede the clinical disease. The immunoglobulin concentrations in serum samples before illness were studied to learn more about the immunological process before RA.

METHODS

A case-control study was nested within a Finnish cohort of 19,072 adults who had neither arthritis nor a history of it at the baseline examination during 1973-1977. By late 1989, 124 had developed RA, of which 89 were positive for rheumatoid factor (RF). Three controls per each incident case were individually matched for sex, age, and municipality. The concentrations of IgG, IgA, and IgM were measured from stored serum samples.

RESULTS

Serum IgG before illness was found to be directly proportional to the risk of RF positive RA, and a non-linear association was present between serum IgA and the risk of RF positive RA. These associations were constant between men and women and other subgroups of the study population and not confounded by serum orosomucoid concentration, level of education, smoking, alcohol intake or body mass index. As adjusted for these factors, the odds ratios (95% confidence intervals) of RF positive RA in the lowest, mid, and highest tertiles of IgG distribution were 1.00, 1.55 (0.81, 2.97), and 2.22 (1.16, 4.26), and in the tertiles of IgA 1.00, 2.23 (1.14, 4.36), and 1.78 (0.89, 3.57), respectively. The associations persisted throughout the entire observation period but were most distinct when the period to the onset of clinical RA was > or = 10 years. IgM carried no predictive significance. None of the serum immunoglobulins predicted the development of RF negative RA.

CONCLUSIONS

Increased IgG levels may reflect some, at present unknown process in the early events leading to the development of RA, typically occurring > or = 10 years before the onset of clinical disease.

Authors+Show Affiliations

National Public Health Institute, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9227163

Citation

Aho, K, et al. "Serum Immunoglobulins and the Risk of Rheumatoid Arthritis." Annals of the Rheumatic Diseases, vol. 56, no. 6, 1997, pp. 351-6.
Aho K, Heliövaara M, Knekt P, et al. Serum immunoglobulins and the risk of rheumatoid arthritis. Ann Rheum Dis. 1997;56(6):351-6.
Aho, K., Heliövaara, M., Knekt, P., Reunanen, A., Aromaa, A., Leino, A., Kurki, P., Heikkilä, R., & Palosuo, T. (1997). Serum immunoglobulins and the risk of rheumatoid arthritis. Annals of the Rheumatic Diseases, 56(6), 351-6.
Aho K, et al. Serum Immunoglobulins and the Risk of Rheumatoid Arthritis. Ann Rheum Dis. 1997;56(6):351-6. PubMed PMID: 9227163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum immunoglobulins and the risk of rheumatoid arthritis. AU - Aho,K, AU - Heliövaara,M, AU - Knekt,P, AU - Reunanen,A, AU - Aromaa,A, AU - Leino,A, AU - Kurki,P, AU - Heikkilä,R, AU - Palosuo,T, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 351 EP - 6 JF - Annals of the rheumatic diseases JO - Ann Rheum Dis VL - 56 IS - 6 N2 - OBJECTIVE: Rheumatoid arthritis (RA) is associated with several autoantibodies that can precede the clinical disease. The immunoglobulin concentrations in serum samples before illness were studied to learn more about the immunological process before RA. METHODS: A case-control study was nested within a Finnish cohort of 19,072 adults who had neither arthritis nor a history of it at the baseline examination during 1973-1977. By late 1989, 124 had developed RA, of which 89 were positive for rheumatoid factor (RF). Three controls per each incident case were individually matched for sex, age, and municipality. The concentrations of IgG, IgA, and IgM were measured from stored serum samples. RESULTS: Serum IgG before illness was found to be directly proportional to the risk of RF positive RA, and a non-linear association was present between serum IgA and the risk of RF positive RA. These associations were constant between men and women and other subgroups of the study population and not confounded by serum orosomucoid concentration, level of education, smoking, alcohol intake or body mass index. As adjusted for these factors, the odds ratios (95% confidence intervals) of RF positive RA in the lowest, mid, and highest tertiles of IgG distribution were 1.00, 1.55 (0.81, 2.97), and 2.22 (1.16, 4.26), and in the tertiles of IgA 1.00, 2.23 (1.14, 4.36), and 1.78 (0.89, 3.57), respectively. The associations persisted throughout the entire observation period but were most distinct when the period to the onset of clinical RA was > or = 10 years. IgM carried no predictive significance. None of the serum immunoglobulins predicted the development of RF negative RA. CONCLUSIONS: Increased IgG levels may reflect some, at present unknown process in the early events leading to the development of RA, typically occurring > or = 10 years before the onset of clinical disease. SN - 0003-4967 UR - https://www.unboundmedicine.com/medline/citation/9227163/Serum_immunoglobulins_and_the_risk_of_rheumatoid_arthritis_ L2 - https://ard.bmj.com/lookup/pmidlookup?view=long&pmid=9227163 DB - PRIME DP - Unbound Medicine ER -