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Congestive heart failure predicts the development of non-insulin-dependent diabetes mellitus in the elderly. The Osservatorio Geriatrico Regione Campania Group.
Diabetes Metab. 1997 Jun; 23(3):213-8.DM

Abstract

Congestive heart failure (CHF) is an insulin-resistant state which constitutes the main risk factor for the development of non-insulin-dependent diabetes mellitus (NIDDM). Our study investigated the predictive role of CHF on the development of NIDDM in 1,339 elderly subjects with a mean (+/- SD) age of 74.2 +/- 6.4 years. CHF had a 9.5% prevalence, and 14.7% of the subjects had NIDDM. After stratification by age, subjects between 80 and 84 years had the highest prevalence of CHF and a total of 29.6% of CHF patients had NIDDM. In multiple logistic regression analysis, CHF was associated with NIDDM [odds ration (OR) = 2.0, 95% confidence interval (CI) - 1.6-2.5] independent of age, sex, family history of diabetes, body mass index, (BMI), waist/hip ratio, and diastolic blood pressure. When only untreated CHF patients were taken into account, the association between CHF and NIDDM was even stronger (OR = 4.0, 95% CI = 3.4-5.8). When untreated CHF patients were grouped into those with low (I and II) and high (III and IV) New York Heart Association (NYHA) classes, the association of CHF and NIDDM was stronger with the worsening of CHF. In a longitudinal study, CHF predicted NIDDM independently of age, sex, family history of diabetes, BMI, waist/hip ratio, systolic and diastolic blood pressure, and therapy for CHF (OR = 1.4, 95% CI = 1.1-1.8). CHF was associated with a higher prevalence of NIDDM and was a risk factor for its development. Elevated FFA concentrations may play a pivotal role.

Authors+Show Affiliations

Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9233998

Citation

Amato, L, et al. "Congestive Heart Failure Predicts the Development of Non-insulin-dependent Diabetes Mellitus in the Elderly. the Osservatorio Geriatrico Regione Campania Group." Diabetes & Metabolism, vol. 23, no. 3, 1997, pp. 213-8.
Amato L, Paolisso G, Cacciatore F, et al. Congestive heart failure predicts the development of non-insulin-dependent diabetes mellitus in the elderly. The Osservatorio Geriatrico Regione Campania Group. Diabetes Metab. 1997;23(3):213-8.
Amato, L., Paolisso, G., Cacciatore, F., Ferrara, N., Ferrara, P., Canonico, S., Varricchio, M., & Rengo, F. (1997). Congestive heart failure predicts the development of non-insulin-dependent diabetes mellitus in the elderly. The Osservatorio Geriatrico Regione Campania Group. Diabetes & Metabolism, 23(3), 213-8.
Amato L, et al. Congestive Heart Failure Predicts the Development of Non-insulin-dependent Diabetes Mellitus in the Elderly. the Osservatorio Geriatrico Regione Campania Group. Diabetes Metab. 1997;23(3):213-8. PubMed PMID: 9233998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Congestive heart failure predicts the development of non-insulin-dependent diabetes mellitus in the elderly. The Osservatorio Geriatrico Regione Campania Group. AU - Amato,L, AU - Paolisso,G, AU - Cacciatore,F, AU - Ferrara,N, AU - Ferrara,P, AU - Canonico,S, AU - Varricchio,M, AU - Rengo,F, PY - 1997/6/1/pubmed PY - 2000/3/11/medline PY - 1997/6/1/entrez SP - 213 EP - 8 JF - Diabetes & metabolism JO - Diabetes Metab VL - 23 IS - 3 N2 - Congestive heart failure (CHF) is an insulin-resistant state which constitutes the main risk factor for the development of non-insulin-dependent diabetes mellitus (NIDDM). Our study investigated the predictive role of CHF on the development of NIDDM in 1,339 elderly subjects with a mean (+/- SD) age of 74.2 +/- 6.4 years. CHF had a 9.5% prevalence, and 14.7% of the subjects had NIDDM. After stratification by age, subjects between 80 and 84 years had the highest prevalence of CHF and a total of 29.6% of CHF patients had NIDDM. In multiple logistic regression analysis, CHF was associated with NIDDM [odds ration (OR) = 2.0, 95% confidence interval (CI) - 1.6-2.5] independent of age, sex, family history of diabetes, body mass index, (BMI), waist/hip ratio, and diastolic blood pressure. When only untreated CHF patients were taken into account, the association between CHF and NIDDM was even stronger (OR = 4.0, 95% CI = 3.4-5.8). When untreated CHF patients were grouped into those with low (I and II) and high (III and IV) New York Heart Association (NYHA) classes, the association of CHF and NIDDM was stronger with the worsening of CHF. In a longitudinal study, CHF predicted NIDDM independently of age, sex, family history of diabetes, BMI, waist/hip ratio, systolic and diastolic blood pressure, and therapy for CHF (OR = 1.4, 95% CI = 1.1-1.8). CHF was associated with a higher prevalence of NIDDM and was a risk factor for its development. Elevated FFA concentrations may play a pivotal role. SN - 1262-3636 UR - https://www.unboundmedicine.com/medline/citation/9233998/Congestive_heart_failure_predicts_the_development_of_non_insulin_dependent_diabetes_mellitus_in_the_elderly__The_Osservatorio_Geriatrico_Regione_Campania_Group_ DB - PRIME DP - Unbound Medicine ER -