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Preoperative D-dimer plasma assay is not a predictor of clinical outcome for patients with advanced ovarian cancer.
Gynecol Oncol. 1997 Jul; 66(1):85-8.GO

Abstract

D-dimer (DD) plasma levels are significantly higher in patients with ovarian cancer than in those with benign ovarian masses. The aim of this paper is to assess whether preoperative DD plasma assay has a prognostic relevance for 35 patients with advanced ovarian cancer receiving platinum-based chemotherapy. Preoperative DD levels ranged from 162 to 3720 ng/ml. The 25, 50, and 75% quartiles of DD levels were 1600, 1894, and 2069 ng/ml, respectively. Preoperative DD levels correlated neither with the common clinicopathological prognostic variables nor with the disease status at the end of first-line chemotherapy. Survival was related to residual disease after initial surgery (> or =2 cm vs <2 cm, P = 0.003), but not to preoperative DD levels. In conclusion, the present data seem to show that preoperative DD plasma assay is not a predictor of clinical outcome for patients with advanced ovarian cancer.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, University of Pisa, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

9234926

Citation

Gadducci, A, et al. "Preoperative D-dimer Plasma Assay Is Not a Predictor of Clinical Outcome for Patients With Advanced Ovarian Cancer." Gynecologic Oncology, vol. 66, no. 1, 1997, pp. 85-8.
Gadducci A, Marrai R, Baicchi U, et al. Preoperative D-dimer plasma assay is not a predictor of clinical outcome for patients with advanced ovarian cancer. Gynecol Oncol. 1997;66(1):85-8.
Gadducci, A., Marrai, R., Baicchi, U., Ferdeghini, M., Fanucchi, A., Weiss, C., & Genazzani, A. R. (1997). Preoperative D-dimer plasma assay is not a predictor of clinical outcome for patients with advanced ovarian cancer. Gynecologic Oncology, 66(1), 85-8.
Gadducci A, et al. Preoperative D-dimer Plasma Assay Is Not a Predictor of Clinical Outcome for Patients With Advanced Ovarian Cancer. Gynecol Oncol. 1997;66(1):85-8. PubMed PMID: 9234926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preoperative D-dimer plasma assay is not a predictor of clinical outcome for patients with advanced ovarian cancer. AU - Gadducci,A, AU - Marrai,R, AU - Baicchi,U, AU - Ferdeghini,M, AU - Fanucchi,A, AU - Weiss,C, AU - Genazzani,A R, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 85 EP - 8 JF - Gynecologic oncology JO - Gynecol Oncol VL - 66 IS - 1 N2 - D-dimer (DD) plasma levels are significantly higher in patients with ovarian cancer than in those with benign ovarian masses. The aim of this paper is to assess whether preoperative DD plasma assay has a prognostic relevance for 35 patients with advanced ovarian cancer receiving platinum-based chemotherapy. Preoperative DD levels ranged from 162 to 3720 ng/ml. The 25, 50, and 75% quartiles of DD levels were 1600, 1894, and 2069 ng/ml, respectively. Preoperative DD levels correlated neither with the common clinicopathological prognostic variables nor with the disease status at the end of first-line chemotherapy. Survival was related to residual disease after initial surgery (> or =2 cm vs <2 cm, P = 0.003), but not to preoperative DD levels. In conclusion, the present data seem to show that preoperative DD plasma assay is not a predictor of clinical outcome for patients with advanced ovarian cancer. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/9234926/Preoperative_D_dimer_plasma_assay_is_not_a_predictor_of_clinical_outcome_for_patients_with_advanced_ovarian_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(97)94704-1 DB - PRIME DP - Unbound Medicine ER -