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Neurological and psychiatric predictors of mortality in patients with Alzheimer disease in California.

Abstract

OBJECTIVE

To determine whether neurological and psychiatric symptoms predict survival time among patients with Alzheimer disease (AD) after adjusting for the influence of sociodemographic variables, health conditions, and dementia severity separately for men and women.

DESIGN

The sample consisted of 936 men and women diagnosed as having probable or possible AD at 1 of 7 Alzheimer's Disease Diagnostic and Treatment Centers throughout California from 1986 through 1990. Data on dementia severity, comorbid conditions, and demographic characteristics were collected at the time of AD diagnosis. Data on vital status and dates of death were obtained by linking the patient file to several administrative databases maintained by the California State and federal governments. The mean length of follow-up was 31 months. Data were analyzed with Kaplan-Meier survival curves and Cox proportional hazards models.

RESULTS

Men had shorter survival times than did women (log-rank test, 30.93, P < .001). Among men, but not women, survival times were negatively associated with selected neurological and psychiatric symptoms. Among women, but not men, a history of cardiovascular conditions was associated with poorer survival.

CONCLUSIONS

Patterns of survival and predictors of survival time among patients with AD differ by sex. Future studies of survival and progression of AD need to examine men and women separately.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Biostatistics, University of California, San Francisco, USA.

    , ,

    Source

    Archives of neurology 54:7 1997 Jul pg 878-85

    MeSH

    Age of Onset
    Aged
    Aged, 80 and over
    Alzheimer Disease
    California
    Female
    Humans
    Male
    Neurologic Examination
    Sex Factors
    Survival Analysis

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    9236577

    Citation

    Moritz, D J., et al. "Neurological and Psychiatric Predictors of Mortality in Patients With Alzheimer Disease in California." Archives of Neurology, vol. 54, no. 7, 1997, pp. 878-85.
    Moritz DJ, Fox PJ, Luscombe FA, et al. Neurological and psychiatric predictors of mortality in patients with Alzheimer disease in California. Arch Neurol. 1997;54(7):878-85.
    Moritz, D. J., Fox, P. J., Luscombe, F. A., & Kraemer, H. C. (1997). Neurological and psychiatric predictors of mortality in patients with Alzheimer disease in California. Archives of Neurology, 54(7), pp. 878-85.
    Moritz DJ, et al. Neurological and Psychiatric Predictors of Mortality in Patients With Alzheimer Disease in California. Arch Neurol. 1997;54(7):878-85. PubMed PMID: 9236577.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Neurological and psychiatric predictors of mortality in patients with Alzheimer disease in California. AU - Moritz,D J, AU - Fox,P J, AU - Luscombe,F A, AU - Kraemer,H C, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 878 EP - 85 JF - Archives of neurology JO - Arch. Neurol. VL - 54 IS - 7 N2 - OBJECTIVE: To determine whether neurological and psychiatric symptoms predict survival time among patients with Alzheimer disease (AD) after adjusting for the influence of sociodemographic variables, health conditions, and dementia severity separately for men and women. DESIGN: The sample consisted of 936 men and women diagnosed as having probable or possible AD at 1 of 7 Alzheimer's Disease Diagnostic and Treatment Centers throughout California from 1986 through 1990. Data on dementia severity, comorbid conditions, and demographic characteristics were collected at the time of AD diagnosis. Data on vital status and dates of death were obtained by linking the patient file to several administrative databases maintained by the California State and federal governments. The mean length of follow-up was 31 months. Data were analyzed with Kaplan-Meier survival curves and Cox proportional hazards models. RESULTS: Men had shorter survival times than did women (log-rank test, 30.93, P < .001). Among men, but not women, survival times were negatively associated with selected neurological and psychiatric symptoms. Among women, but not men, a history of cardiovascular conditions was associated with poorer survival. CONCLUSIONS: Patterns of survival and predictors of survival time among patients with AD differ by sex. Future studies of survival and progression of AD need to examine men and women separately. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/9236577/Neurological_and_psychiatric_predictors_of_mortality_in_patients_with_Alzheimer_disease_in_California_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/54/pg/878 DB - PRIME DP - Unbound Medicine ER -