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Relationship between pentosidine levels in serum and urine and activity in rheumatoid arthritis.

Abstract

Pentosidine is one of the advanced glycation end-products and is formed by glycosylation and oxidation. The aim of this study is to investigate the relationship between serum and urinary pentosidine levels and the activity of rheumatoid arthritis (RA). Using HPLC with column switching, we measured pentosidine in serum and urine from 77 patients with RA and 62 normal control subjects. The clinical features, blood biochemistry and activity of inflammation were examined in RA patients. Serum and urinary pentosidine in RA were significantly higher than in controls. Pentosidine significantly correlated with age, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor, joint score and Lansbury Index in RA. The levels of pentosidine were higher in patients with active RA than in those with inactive RA. Serum and urine levels of pentosidine correlated with the activity of RA, and serum and urinary pentosidine may be a significant and novel marker for evaluating the disease status and the activity of RA.

Authors+Show Affiliations

,

Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, Japan.

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Source

British journal of rheumatology 36:6 1997 Jun pg 637-42

MeSH

Adult
Aged
Arginine
Arthritis, Rheumatoid
Body Fluids
Chromatography, High Pressure Liquid
Cross-Linking Reagents
Female
Humans
Lysine
Middle Aged

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

9236672

Citation

Takahashi, M, et al. "Relationship Between Pentosidine Levels in Serum and Urine and Activity in Rheumatoid Arthritis." British Journal of Rheumatology, vol. 36, no. 6, 1997, pp. 637-42.
Takahashi M, Suzuki M, Kushida K, et al. Relationship between pentosidine levels in serum and urine and activity in rheumatoid arthritis. Br J Rheumatol. 1997;36(6):637-42.
Takahashi, M., Suzuki, M., Kushida, K., Miyamoto, S., & Inoue, T. (1997). Relationship between pentosidine levels in serum and urine and activity in rheumatoid arthritis. British Journal of Rheumatology, 36(6), pp. 637-42.
Takahashi M, et al. Relationship Between Pentosidine Levels in Serum and Urine and Activity in Rheumatoid Arthritis. Br J Rheumatol. 1997;36(6):637-42. PubMed PMID: 9236672.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between pentosidine levels in serum and urine and activity in rheumatoid arthritis. AU - Takahashi,M, AU - Suzuki,M, AU - Kushida,K, AU - Miyamoto,S, AU - Inoue,T, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 637 EP - 42 JF - British journal of rheumatology JO - Br. J. Rheumatol. VL - 36 IS - 6 N2 - Pentosidine is one of the advanced glycation end-products and is formed by glycosylation and oxidation. The aim of this study is to investigate the relationship between serum and urinary pentosidine levels and the activity of rheumatoid arthritis (RA). Using HPLC with column switching, we measured pentosidine in serum and urine from 77 patients with RA and 62 normal control subjects. The clinical features, blood biochemistry and activity of inflammation were examined in RA patients. Serum and urinary pentosidine in RA were significantly higher than in controls. Pentosidine significantly correlated with age, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor, joint score and Lansbury Index in RA. The levels of pentosidine were higher in patients with active RA than in those with inactive RA. Serum and urine levels of pentosidine correlated with the activity of RA, and serum and urinary pentosidine may be a significant and novel marker for evaluating the disease status and the activity of RA. SN - 0263-7103 UR - https://www.unboundmedicine.com/medline/citation/9236672/Relationship_between_pentosidine_levels_in_serum_and_urine_and_activity_in_rheumatoid_arthritis_ L2 - http://www.diseaseinfosearch.org/result/592 DB - PRIME DP - Unbound Medicine ER -