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Asterlingulatosides C and D, cytotoxic triterpenoid saponins from Aster lingulatus.
J Nat Prod. 1997 Jul; 60(7):743-6.JN

Abstract

A further investigation of Aster lingulatus has led to the isolation of two additional novel triterpene saponins, asterlingulatoside C [3-O-beta-D-glucopyranosyl-3 beta, 16 alpha-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-alpha- L- arabinopyranoside] (1) and asterlingulatoside D [3-O-beta-D-glucopyranosyl-3 beta,16 alpha-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-alpha-L- rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside] (2). Elucidation of the structures of 1 and 2 was mainly based on FABMS and 1D and 2D homonuclear and heteronuclear NMR techniques. Compounds 1 and 2 showed good inhibitory activity against DNA synthesis in human leukemia HL-60 cells with IC50 values of 8.8 and 6.1 microM, respectively.

Authors+Show Affiliations

Shao Y
Department of Plant Science, Cook College, Rutgers, State University of New Jersey, New Brunswich 08903, USA.
Ho CT
No affiliation info available
Chin CK
No affiliation info available
Poobrasert O
No affiliation info available
Yang SW
No affiliation info available
Cordell GA
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicHL-60 CellsHumansMagnetic Resonance SpectroscopyOleanolic AcidPlants, MedicinalSaponinsSpectrometry, Mass, Fast Atom BombardmentStructure-Activity Relationship

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9249983

Citation

Shao, Y, et al. "Asterlingulatosides C and D, Cytotoxic Triterpenoid Saponins From Aster Lingulatus." Journal of Natural Products, vol. 60, no. 7, 1997, pp. 743-6.
Shao Y, Ho CT, Chin CK, et al. Asterlingulatosides C and D, cytotoxic triterpenoid saponins from Aster lingulatus. J Nat Prod. 1997;60(7):743-6.
Shao, Y., Ho, C. T., Chin, C. K., Poobrasert, O., Yang, S. W., & Cordell, G. A. (1997). Asterlingulatosides C and D, cytotoxic triterpenoid saponins from Aster lingulatus. Journal of Natural Products, 60(7), 743-6.
Shao Y, et al. Asterlingulatosides C and D, Cytotoxic Triterpenoid Saponins From Aster Lingulatus. J Nat Prod. 1997;60(7):743-6. PubMed PMID: 9249983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Asterlingulatosides C and D, cytotoxic triterpenoid saponins from Aster lingulatus. AU - Shao,Y, AU - Ho,C T, AU - Chin,C K, AU - Poobrasert,O, AU - Yang,S W, AU - Cordell,G A, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 743 EP - 6 JF - Journal of natural products JO - J Nat Prod VL - 60 IS - 7 N2 - A further investigation of Aster lingulatus has led to the isolation of two additional novel triterpene saponins, asterlingulatoside C [3-O-beta-D-glucopyranosyl-3 beta, 16 alpha-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->4)-alpha-L-rhamnopyranosyl-(1-->2)-alpha- L- arabinopyranoside] (1) and asterlingulatoside D [3-O-beta-D-glucopyranosyl-3 beta,16 alpha-dihydroxyolean-12-en-28-oic acid 28-O-beta-D-xylopyranosyl-(1-->3)-beta-D-xylopyranosyl-(1-->4)-alpha-L- rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside] (2). Elucidation of the structures of 1 and 2 was mainly based on FABMS and 1D and 2D homonuclear and heteronuclear NMR techniques. Compounds 1 and 2 showed good inhibitory activity against DNA synthesis in human leukemia HL-60 cells with IC50 values of 8.8 and 6.1 microM, respectively. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/9249983/Asterlingulatosides_C_and_D_cytotoxic_triterpenoid_saponins_from_Aster_lingulatus_ L2 - https://doi.org/10.1021/np970080t DB - PRIME DP - Unbound Medicine ER -