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Interaction of exercise training and chronic ethanol ingestion on hepatic and plasma antioxidant system in rat.
J Appl Toxicol. 1997 May-Jun; 17(3):189-94.JA

Abstract

This study was undertaken in order to investigate the interactive effects of exercise training and chronic ethanol consumption on the antioxidant system in rat liver and plasma. Fisher-344 rats were treated in separate groups as follows: sedentary control (SC); exercise training (ET) for 6.5 weeks; ethanol 20% (2.0 g kg-1, p.o.) for 6.5 weeks; and ET and ethanol administration. In liver, ET significantly decreased the malondialdehyde (MDA) level (73% of SC). Chronic ethanol significantly increased catalase (CAT) activity and MDA levels (126% and 135% of SC), respectively, and also depleted the reduced glutathione (GSH) level and the reduced to oxidized glutathione (GSH/GSSG) ratio (81% and 38% of SC), respectively. Exercise training plus ethanol significantly increased CAT and glutathione reductase (GR) activity (126% and 118% of SC), respectively, and decreased the MDA level (67% of SC). In plasma, ethanol significantly enhanced CAT activity and MDA levels (173% and 221% of SC), respectively. Ethanol ingestion also increased the CAT/superoxide dismutase (SOD) ratio (216% of SC) in plasma. Training plus ethanol ingestion significantly increased CAT activity and MDA levels (208% and 148% of SC), respectively, and increased CAT/SOD and glutathione peroxidase (GSH-Px)/SOD ratios (279% and 142% of SC), respectively. The data indicate that the combination of exercise and ethanol ingestion resulted in an enhanced hepatic CAT and GR activity to eliminate H2O2 and to maintain endogenous GSH levels. Thus, training ameliorated the ethanol-induced oxidative injury in the liver. The ratio of CAT/SOD in plasma increased twofold due to chronic ethanol intake and threefold due to the combination, which may be used as an index of oxidative stress.

Authors+Show Affiliations

Department of Pharmacology, Southern Illinois University School of Medicine, Springfield 62794-1222, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9250541

Citation

Husain, K, and S M. Somani. "Interaction of Exercise Training and Chronic Ethanol Ingestion On Hepatic and Plasma Antioxidant System in Rat." Journal of Applied Toxicology : JAT, vol. 17, no. 3, 1997, pp. 189-94.
Husain K, Somani SM. Interaction of exercise training and chronic ethanol ingestion on hepatic and plasma antioxidant system in rat. J Appl Toxicol. 1997;17(3):189-94.
Husain, K., & Somani, S. M. (1997). Interaction of exercise training and chronic ethanol ingestion on hepatic and plasma antioxidant system in rat. Journal of Applied Toxicology : JAT, 17(3), 189-94.
Husain K, Somani SM. Interaction of Exercise Training and Chronic Ethanol Ingestion On Hepatic and Plasma Antioxidant System in Rat. J Appl Toxicol. 1997 May-Jun;17(3):189-94. PubMed PMID: 9250541.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of exercise training and chronic ethanol ingestion on hepatic and plasma antioxidant system in rat. AU - Husain,K, AU - Somani,S M, PY - 1997/5/1/pubmed PY - 2000/6/20/medline PY - 1997/5/1/entrez SP - 189 EP - 94 JF - Journal of applied toxicology : JAT JO - J Appl Toxicol VL - 17 IS - 3 N2 - This study was undertaken in order to investigate the interactive effects of exercise training and chronic ethanol consumption on the antioxidant system in rat liver and plasma. Fisher-344 rats were treated in separate groups as follows: sedentary control (SC); exercise training (ET) for 6.5 weeks; ethanol 20% (2.0 g kg-1, p.o.) for 6.5 weeks; and ET and ethanol administration. In liver, ET significantly decreased the malondialdehyde (MDA) level (73% of SC). Chronic ethanol significantly increased catalase (CAT) activity and MDA levels (126% and 135% of SC), respectively, and also depleted the reduced glutathione (GSH) level and the reduced to oxidized glutathione (GSH/GSSG) ratio (81% and 38% of SC), respectively. Exercise training plus ethanol significantly increased CAT and glutathione reductase (GR) activity (126% and 118% of SC), respectively, and decreased the MDA level (67% of SC). In plasma, ethanol significantly enhanced CAT activity and MDA levels (173% and 221% of SC), respectively. Ethanol ingestion also increased the CAT/superoxide dismutase (SOD) ratio (216% of SC) in plasma. Training plus ethanol ingestion significantly increased CAT activity and MDA levels (208% and 148% of SC), respectively, and increased CAT/SOD and glutathione peroxidase (GSH-Px)/SOD ratios (279% and 142% of SC), respectively. The data indicate that the combination of exercise and ethanol ingestion resulted in an enhanced hepatic CAT and GR activity to eliminate H2O2 and to maintain endogenous GSH levels. Thus, training ameliorated the ethanol-induced oxidative injury in the liver. The ratio of CAT/SOD in plasma increased twofold due to chronic ethanol intake and threefold due to the combination, which may be used as an index of oxidative stress. SN - 0260-437X UR - https://www.unboundmedicine.com/medline/citation/9250541/Interaction_of_exercise_training_and_chronic_ethanol_ingestion_on_hepatic_and_plasma_antioxidant_system_in_rat_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0260-437X&date=1997&volume=17&issue=3&spage=189 DB - PRIME DP - Unbound Medicine ER -