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Isolation of a new Orientia tsutsugamushi serotype.
Microbiol Immunol. 1997; 41(6):437-43.MI

Abstract

Orientia tsutsugamushi, the etiological agent of scrub typhus, is an antigenically diverse organism and many serologically distinct strains have been identified. The 56 kDa protein of O. tsutsugamushi, a major protein in the outer membrane, has been thought to be responsible for this antigenic variability. A strain of O. tsutsugamushi isolated in Korea cross-reacted with both Gilliam strain-specific and Karp strain-specific monoclonal antibodies. When its 56 kDa protein gene was cloned and analyzed, its sequence showed variation especially between 1,200 and 1,250 bp, showing that this isolate is a new O. tsutsugamushi strain.

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Authors+Show Affiliations

Seong SY
Department of Microbiology, Seoul National University College of Medicine, Republic of Korea.
Park SG
No affiliation info available
Kim HR
No affiliation info available
Han TH
No affiliation info available
Kang JS
No affiliation info available
Choi MS
No affiliation info available
Kim IS
No affiliation info available
Chang WH
No affiliation info available

MeSH

Amino Acid SequenceAntibodies, BacterialAntibodies, MonoclonalAntibody SpecificityAntigenic VariationAntigens, BacterialBacterial Outer Membrane ProteinsBase SequenceGenes, BacterialHumansKoreaMolecular Sequence DataOrientia tsutsugamushiPolymerase Chain ReactionScrub TyphusSequence Analysis, DNASequence Homology, Amino AcidSerotyping

Pub Type(s)

Case Reports
Comparative Study
Journal Article

Language

eng

PubMed ID

9251054

Citation

Seong, S Y., et al. "Isolation of a New Orientia Tsutsugamushi Serotype." Microbiology and Immunology, vol. 41, no. 6, 1997, pp. 437-43.
Seong SY, Park SG, Kim HR, et al. Isolation of a new Orientia tsutsugamushi serotype. Microbiol Immunol. 1997;41(6):437-43.
Seong, S. Y., Park, S. G., Kim, H. R., Han, T. H., Kang, J. S., Choi, M. S., Kim, I. S., & Chang, W. H. (1997). Isolation of a new Orientia tsutsugamushi serotype. Microbiology and Immunology, 41(6), 437-43.
Seong SY, et al. Isolation of a New Orientia Tsutsugamushi Serotype. Microbiol Immunol. 1997;41(6):437-43. PubMed PMID: 9251054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation of a new Orientia tsutsugamushi serotype. AU - Seong,S Y, AU - Park,S G, AU - Kim,H R, AU - Han,T H, AU - Kang,J S, AU - Choi,M S, AU - Kim,I S, AU - Chang,W H, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 437 EP - 43 JF - Microbiology and immunology JO - Microbiol Immunol VL - 41 IS - 6 N2 - Orientia tsutsugamushi, the etiological agent of scrub typhus, is an antigenically diverse organism and many serologically distinct strains have been identified. The 56 kDa protein of O. tsutsugamushi, a major protein in the outer membrane, has been thought to be responsible for this antigenic variability. A strain of O. tsutsugamushi isolated in Korea cross-reacted with both Gilliam strain-specific and Karp strain-specific monoclonal antibodies. When its 56 kDa protein gene was cloned and analyzed, its sequence showed variation especially between 1,200 and 1,250 bp, showing that this isolate is a new O. tsutsugamushi strain. SN - 0385-5600 UR - https://www.unboundmedicine.com/medline/citation/9251054/Isolation_of_a_new_Orientia_tsutsugamushi_serotype_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0385-5600&date=1997&volume=41&issue=6&spage=437 DB - PRIME DP - Unbound Medicine ER -