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Effect of cholecystokinin-A receptor blockade on lipid-induced gastric relaxation in humans.
Am J Physiol. 1997 Jul; 273(1 Pt 1):G118-23.AJ

Abstract

The purpose of this study was to assess the role of endogenous cholecystokinin (CCK) in regulating fat-induced changes in human gastric relaxation. Proximal gastric pressure-volume relationships were determined in 12 healthy volunteers during a series of gastric distensions, both fasting and after intragastric instillation of 250 ml of 10% Intralipid. All subjects were studied twice, in a randomized, double-blind study, during intravenous infusion of either loxiglumide (CCK-A antagonist) or saline. For each distension, intragastric pressure and compliance were determined together with perception intensity. During saline infusion, Intralipid reduced intragastric pressure (prelipid, 11.7 +/- 0.8; postlipid, 9.7 +/- 0.6 mmHg; P = 0.002) and increased compliance (pressure-volume slope values: prelipid, 87.6 +/- 9.7; postlipid, 47.2 +/- 7; P < 0.01). Loxiglumide infusion during fasting exerted no effect on either intragastric pressure or compliance. After lipid, however, loxiglumide abolished the expected postlipid reduction in intragastric pressure (prelipid, 12.1 +/- 0.7; postlipid, 11.5 +/- 0.8 mmHg; P = 0.4) but did not consistently abolish the postlipid increase in compliance. Loxiglumide exerted no effect on the cumulative perception score or on the volume at perception threshold, although it prevented the fat-induced reduction in pressure at perception threshold [control: prelipid, 15.4 +/- 1.1; postlipid, 10.7 +/- 0.5 (P < 0.05); loxiglumide: prelipid, 13.8 +/- 1.5; postlipid, 12.2 +/- 0.9 (P > 0.05)]. Endogenous CCK or CCK-A receptors therefore play a role in the fat-induced reduction of intragastric pressure and might also modulate gastric perception after lipid.

Authors+Show Affiliations

Department of Medicine, Hope Hospital, University of Manchester School of Medicine, Salford, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9252517

Citation

Mesquita, M A., et al. "Effect of cholecystokinin-A Receptor Blockade On Lipid-induced Gastric Relaxation in Humans." The American Journal of Physiology, vol. 273, no. 1 Pt 1, 1997, pp. G118-23.
Mesquita MA, Thompson DG, Troncon LE, et al. Effect of cholecystokinin-A receptor blockade on lipid-induced gastric relaxation in humans. Am J Physiol. 1997;273(1 Pt 1):G118-23.
Mesquita, M. A., Thompson, D. G., Troncon, L. E., D'Amato, M., Rovati, L. C., & Barlow, J. (1997). Effect of cholecystokinin-A receptor blockade on lipid-induced gastric relaxation in humans. The American Journal of Physiology, 273(1 Pt 1), G118-23.
Mesquita MA, et al. Effect of cholecystokinin-A Receptor Blockade On Lipid-induced Gastric Relaxation in Humans. Am J Physiol. 1997;273(1 Pt 1):G118-23. PubMed PMID: 9252517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cholecystokinin-A receptor blockade on lipid-induced gastric relaxation in humans. AU - Mesquita,M A, AU - Thompson,D G, AU - Troncon,L E, AU - D'Amato,M, AU - Rovati,L C, AU - Barlow,J, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - G118 EP - 23 JF - The American journal of physiology JO - Am J Physiol VL - 273 IS - 1 Pt 1 N2 - The purpose of this study was to assess the role of endogenous cholecystokinin (CCK) in regulating fat-induced changes in human gastric relaxation. Proximal gastric pressure-volume relationships were determined in 12 healthy volunteers during a series of gastric distensions, both fasting and after intragastric instillation of 250 ml of 10% Intralipid. All subjects were studied twice, in a randomized, double-blind study, during intravenous infusion of either loxiglumide (CCK-A antagonist) or saline. For each distension, intragastric pressure and compliance were determined together with perception intensity. During saline infusion, Intralipid reduced intragastric pressure (prelipid, 11.7 +/- 0.8; postlipid, 9.7 +/- 0.6 mmHg; P = 0.002) and increased compliance (pressure-volume slope values: prelipid, 87.6 +/- 9.7; postlipid, 47.2 +/- 7; P < 0.01). Loxiglumide infusion during fasting exerted no effect on either intragastric pressure or compliance. After lipid, however, loxiglumide abolished the expected postlipid reduction in intragastric pressure (prelipid, 12.1 +/- 0.7; postlipid, 11.5 +/- 0.8 mmHg; P = 0.4) but did not consistently abolish the postlipid increase in compliance. Loxiglumide exerted no effect on the cumulative perception score or on the volume at perception threshold, although it prevented the fat-induced reduction in pressure at perception threshold [control: prelipid, 15.4 +/- 1.1; postlipid, 10.7 +/- 0.5 (P < 0.05); loxiglumide: prelipid, 13.8 +/- 1.5; postlipid, 12.2 +/- 0.9 (P > 0.05)]. Endogenous CCK or CCK-A receptors therefore play a role in the fat-induced reduction of intragastric pressure and might also modulate gastric perception after lipid. SN - 0002-9513 UR - https://www.unboundmedicine.com/medline/citation/9252517/Effect_of_cholecystokinin_A_receptor_blockade_on_lipid_induced_gastric_relaxation_in_humans_ L2 - https://journals.physiology.org/doi/10.1152/ajpgi.1997.273.1.G118?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -