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A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.
Genome Res. 1997 Jul; 7(7):725-35.GR

Abstract

Multiple endocrine neoplasia type 1 (MEN 1) is an inherited cancer syndrome in which affected individuals develop multiple parathyroid, enteropancreatic, and pituitary tumors. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis places the MEN1 gene within a 2-Mb interval flanked by the markers D11S1883 and D11S449. Loss of heterozygosity studies in MEN 1 and sporadic tumors suggest that the MEN1 gene encodes a tumor suppressor and have helped to narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Focusing on this smaller MEN1 interval, we have identified and mapped 12 transcripts to this 600-kb region. A precise ordered map of 33 transcripts, including 12 genes known to map to this region, was generated for the 2.8-Mb D11S480-D11S913 interval. Fifteen candidate genes (of which 10 were examined exhaustively) were evaluated by Southern blot and/or dideoxy fingerprinting analysis to identify the gene harboring disease-causing mutations.

Authors

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Pub Type(s)

Letter
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9253601

Citation

Guru, S C., et al. "A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus." Genome Research, vol. 7, no. 7, 1997, pp. 725-35.
Guru SC, Agarwal SK, Manickam P, et al. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. Genome Res. 1997;7(7):725-35.
Guru, S. C., Agarwal, S. K., Manickam, P., Olufemi, S. E., Crabtree, J. S., Weisemann, J. M., Kester, M. B., Kim, Y. S., Wang, Y., Emmert-Buck, M. R., Liotta, L. A., Spiegel, A. M., Boguski, M. S., Roe, B. A., Collins, F. S., Marx, S. J., Burns, L., & Chandrasekharappa, S. C. (1997). A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. Genome Research, 7(7), 725-35.
Guru SC, et al. A Transcript Map for the 2.8-Mb Region Containing the Multiple Endocrine Neoplasia Type 1 Locus. Genome Res. 1997;7(7):725-35. PubMed PMID: 9253601.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. AU - Guru,S C, AU - Agarwal,S K, AU - Manickam,P, AU - Olufemi,S E, AU - Crabtree,J S, AU - Weisemann,J M, AU - Kester,M B, AU - Kim,Y S, AU - Wang,Y, AU - Emmert-Buck,M R, AU - Liotta,L A, AU - Spiegel,A M, AU - Boguski,M S, AU - Roe,B A, AU - Collins,F S, AU - Marx,S J, AU - Burns,L, AU - Chandrasekharappa,S C, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 725 EP - 35 JF - Genome research JO - Genome Res VL - 7 IS - 7 N2 - Multiple endocrine neoplasia type 1 (MEN 1) is an inherited cancer syndrome in which affected individuals develop multiple parathyroid, enteropancreatic, and pituitary tumors. The locus for MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis places the MEN1 gene within a 2-Mb interval flanked by the markers D11S1883 and D11S449. Loss of heterozygosity studies in MEN 1 and sporadic tumors suggest that the MEN1 gene encodes a tumor suppressor and have helped to narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Focusing on this smaller MEN1 interval, we have identified and mapped 12 transcripts to this 600-kb region. A precise ordered map of 33 transcripts, including 12 genes known to map to this region, was generated for the 2.8-Mb D11S480-D11S913 interval. Fifteen candidate genes (of which 10 were examined exhaustively) were evaluated by Southern blot and/or dideoxy fingerprinting analysis to identify the gene harboring disease-causing mutations. SN - 1088-9051 UR - https://www.unboundmedicine.com/medline/citation/9253601/A_transcript_map_for_the_2_8_Mb_region_containing_the_multiple_endocrine_neoplasia_type_1_locus_ L2 - http://genome.cshlp.org/cgi/pmidlookup?view=long&pmid=9253601 DB - PRIME DP - Unbound Medicine ER -