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Inhibitory effects of Korean folk medicine 'Hi-Chum' on histamine release from mast cells in vivo and in vitro.
J Ethnopharmacol. 1997 Jul; 57(2):73-9.JE

Abstract

The effect of aqueous extract of Siegesbeckia glabrescence (Compositae) whole plants (SGWP) on systemic or local anaphylaxis was studied. SGWP inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 1000 mg/kg. Oral administration of SGWP (100 mg/kg) showed a marked inhibition rate in local immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. When SGWP was pretreated at concentration ranging from 0.1 to 1000 mg/kg, the serum histamine levels were reduced in a dose-dependent manner. Moreover, SGWP dose-dependently inhibited the histamine release from peritoneal mast cells by compound 48/80. These results indicate that SGWP possess strong antianaphylactic activity by inhibition of histamine release from mast cells.

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Authors+Show Affiliations

Kang BK
Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, South Korea.
Lee EH
No affiliation info available
Kim HM
No affiliation info available

MeSH

AnaphylaxisAnimalsHistamine H1 AntagonistsHistamine ReleaseImmunoglobulin EMast CellsMedicine, TraditionalMiceMice, Inbred BALB CPlants, MedicinalRatsRats, Wistarp-Methoxy-N-methylphenethylamine

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9254108

Citation

Kang, B K., et al. "Inhibitory Effects of Korean Folk Medicine 'Hi-Chum' On Histamine Release From Mast Cells in Vivo and in Vitro." Journal of Ethnopharmacology, vol. 57, no. 2, 1997, pp. 73-9.
Kang BK, Lee EH, Kim HM. Inhibitory effects of Korean folk medicine 'Hi-Chum' on histamine release from mast cells in vivo and in vitro. J Ethnopharmacol. 1997;57(2):73-9.
Kang, B. K., Lee, E. H., & Kim, H. M. (1997). Inhibitory effects of Korean folk medicine 'Hi-Chum' on histamine release from mast cells in vivo and in vitro. Journal of Ethnopharmacology, 57(2), 73-9.
Kang BK, Lee EH, Kim HM. Inhibitory Effects of Korean Folk Medicine 'Hi-Chum' On Histamine Release From Mast Cells in Vivo and in Vitro. J Ethnopharmacol. 1997;57(2):73-9. PubMed PMID: 9254108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of Korean folk medicine 'Hi-Chum' on histamine release from mast cells in vivo and in vitro. AU - Kang,B K, AU - Lee,E H, AU - Kim,H M, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 73 EP - 9 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 57 IS - 2 N2 - The effect of aqueous extract of Siegesbeckia glabrescence (Compositae) whole plants (SGWP) on systemic or local anaphylaxis was studied. SGWP inhibited compound 48/80-induced systemic anaphylaxis 100% with a dose of 1000 mg/kg. Oral administration of SGWP (100 mg/kg) showed a marked inhibition rate in local immunoglobulin E (IgE)-mediated passive cutaneous anaphylaxis reaction. When SGWP was pretreated at concentration ranging from 0.1 to 1000 mg/kg, the serum histamine levels were reduced in a dose-dependent manner. Moreover, SGWP dose-dependently inhibited the histamine release from peritoneal mast cells by compound 48/80. These results indicate that SGWP possess strong antianaphylactic activity by inhibition of histamine release from mast cells. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/9254108/Inhibitory_effects_of_Korean_folk_medicine_'Hi_Chum'_on_histamine_release_from_mast_cells_in_vivo_and_in_vitro_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(97)00047-0 DB - PRIME DP - Unbound Medicine ER -