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The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype.
J Bone Miner Res. 1997 Aug; 12(8):1241-5.JB

Abstract

Recent studies suggest that variations of the vitamin D receptor (VDR) gene are related to bone mineral density (BMD). In this study, we examined the effect of vitamin D3 supplementation on BMD at the femoral neck in relation to VDR genotype. We analyzed 81 women, age 70 years and over, who participated in a placebo-controlled clinical trial on the effect of vitamin D3 supplementation (400 IU daily for at least 2 years) on BMD and fracture incidence. VDR genotype was based on the presence (b) or absence (B) of the BsmI restriction site. Mean BMD of the right and left femoral neck was measured at baseline and after 1 and 2 years. Dietary calcium, body mass index, and years since menopause were assessed at baseline while biochemical markers were measured at baseline and after 1 year. There was no difference among the BB, Bb, and bb genotype for baseline measurements of BMD at the femoral neck (mean and SD, g/cm2: 0.70 (0.10), 0.71 (0.12), and 0.69 (0.10), respectively), nor for any of the biochemical indices. The mean increase of BMD in the vitamin D group relative to the placebo group, expressed as percentage of baseline BMD, was significantly higher (p = 0.03) in the BB (delta BMD: 4.4%, p = 0.04) and Bb genotype (delta BMD: 4.2%, p = 0.007) compared with the bb genotype (delta BMD: -0.3%, p = 0.61). No significant changes were found for any of the other measured parameters. The VDR genotype-dependent effect of vitamin D supplementation in these elderly subjects suggest a functional involvement of VDR gene variants in determining BMD.

Authors+Show Affiliations

Institute for Research in Extramural Medicine (EMGO Institute), Vrije Universiteit, Amsterdam, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9258754

Citation

Graafmans, W C., et al. "The Effect of Vitamin D Supplementation On the Bone Mineral Density of the Femoral Neck Is Associated With Vitamin D Receptor Genotype." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 12, no. 8, 1997, pp. 1241-5.
Graafmans WC, Lips P, Ooms ME, et al. The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype. J Bone Miner Res. 1997;12(8):1241-5.
Graafmans, W. C., Lips, P., Ooms, M. E., van Leeuwen, J. P., Pols, H. A., & Uitterlinden, A. G. (1997). The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 12(8), 1241-5.
Graafmans WC, et al. The Effect of Vitamin D Supplementation On the Bone Mineral Density of the Femoral Neck Is Associated With Vitamin D Receptor Genotype. J Bone Miner Res. 1997;12(8):1241-5. PubMed PMID: 9258754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of vitamin D supplementation on the bone mineral density of the femoral neck is associated with vitamin D receptor genotype. AU - Graafmans,W C, AU - Lips,P, AU - Ooms,M E, AU - van Leeuwen,J P, AU - Pols,H A, AU - Uitterlinden,A G, PY - 1997/8/1/pubmed PY - 1997/8/1/medline PY - 1997/8/1/entrez SP - 1241 EP - 5 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 12 IS - 8 N2 - Recent studies suggest that variations of the vitamin D receptor (VDR) gene are related to bone mineral density (BMD). In this study, we examined the effect of vitamin D3 supplementation on BMD at the femoral neck in relation to VDR genotype. We analyzed 81 women, age 70 years and over, who participated in a placebo-controlled clinical trial on the effect of vitamin D3 supplementation (400 IU daily for at least 2 years) on BMD and fracture incidence. VDR genotype was based on the presence (b) or absence (B) of the BsmI restriction site. Mean BMD of the right and left femoral neck was measured at baseline and after 1 and 2 years. Dietary calcium, body mass index, and years since menopause were assessed at baseline while biochemical markers were measured at baseline and after 1 year. There was no difference among the BB, Bb, and bb genotype for baseline measurements of BMD at the femoral neck (mean and SD, g/cm2: 0.70 (0.10), 0.71 (0.12), and 0.69 (0.10), respectively), nor for any of the biochemical indices. The mean increase of BMD in the vitamin D group relative to the placebo group, expressed as percentage of baseline BMD, was significantly higher (p = 0.03) in the BB (delta BMD: 4.4%, p = 0.04) and Bb genotype (delta BMD: 4.2%, p = 0.007) compared with the bb genotype (delta BMD: -0.3%, p = 0.61). No significant changes were found for any of the other measured parameters. The VDR genotype-dependent effect of vitamin D supplementation in these elderly subjects suggest a functional involvement of VDR gene variants in determining BMD. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/9258754/The_effect_of_vitamin_D_supplementation_on_the_bone_mineral_density_of_the_femoral_neck_is_associated_with_vitamin_D_receptor_genotype_ L2 - https://doi.org/10.1359/jbmr.1997.12.8.1241 DB - PRIME DP - Unbound Medicine ER -