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RETRACTED ARTICLE

Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness.
Can J Anaesth. 1997 Aug; 44(8):820-4.CJ

Abstract

PURPOSE

Motion sickness is one of the patient-related factors associated with postoperative nausea and vomiting (PONV). This study was undertaken to assess the efficacy of granisetron, droperidol and metoclopramide for preventing PONV in female patients with a history of motion sickness undergoing major gynaecological surgery.

METHODS

In a prospective, randomized, placebo-controlled, double-blind study, 120 patients received either 1.25 mg droperidol, 10 mg metoclopramide, 40 micrograms.kg-1 granisetron or placebo (saline) iv immediately before induction of anaesthesia. A standardized anaesthetic technique and postoperative analgesia were used in all patients. During the first 24 hr after anaesthesia, the incidence of PONV and adverse events were recorded by nursing-staff.

RESULTS

The treatment groups were similar for patient demographics, types of surgery, anaesthetics administered and opioid given. The incidence of PONV was 70%, 50%, 57% and 23% in the placebo, droperidol, metoclopramide and granisetron groups, respectively (P < 0.05; overall chi 2 test). No difference in the incidence of adverse events was observed in either group.

CONCLUSION

Granisetron is a better prophylactic antiemetic than droperidol or metoclopramide in female patients with a history of motion sickness undergoing major gynaecological surgery.

Authors+Show Affiliations

Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Ibaraki, Japan.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Retracted Publication

Language

eng

PubMed ID

9260009

Citation

Fujii, Y, et al. "Prevention of PONV With Granisetron, Droperidol and Metoclopramide in Female Patients With History of Motion Sickness." Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, vol. 44, no. 8, 1997, pp. 820-4.
Fujii Y, Toyooka H, Tanaka H. Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. Can J Anaesth. 1997;44(8):820-4.
Fujii, Y., Toyooka, H., & Tanaka, H. (1997). Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie, 44(8), 820-4.
Fujii Y, Toyooka H, Tanaka H. Prevention of PONV With Granisetron, Droperidol and Metoclopramide in Female Patients With History of Motion Sickness. Can J Anaesth. 1997;44(8):820-4. PubMed PMID: 9260009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of PONV with granisetron, droperidol and metoclopramide in female patients with history of motion sickness. AU - Fujii,Y, AU - Toyooka,H, AU - Tanaka,H, PY - 1997/8/1/pubmed PY - 1997/8/1/medline PY - 1997/8/1/entrez SP - 820 EP - 4 JF - Canadian journal of anaesthesia = Journal canadien d'anesthesie JO - Can J Anaesth VL - 44 IS - 8 N2 - PURPOSE: Motion sickness is one of the patient-related factors associated with postoperative nausea and vomiting (PONV). This study was undertaken to assess the efficacy of granisetron, droperidol and metoclopramide for preventing PONV in female patients with a history of motion sickness undergoing major gynaecological surgery. METHODS: In a prospective, randomized, placebo-controlled, double-blind study, 120 patients received either 1.25 mg droperidol, 10 mg metoclopramide, 40 micrograms.kg-1 granisetron or placebo (saline) iv immediately before induction of anaesthesia. A standardized anaesthetic technique and postoperative analgesia were used in all patients. During the first 24 hr after anaesthesia, the incidence of PONV and adverse events were recorded by nursing-staff. RESULTS: The treatment groups were similar for patient demographics, types of surgery, anaesthetics administered and opioid given. The incidence of PONV was 70%, 50%, 57% and 23% in the placebo, droperidol, metoclopramide and granisetron groups, respectively (P < 0.05; overall chi 2 test). No difference in the incidence of adverse events was observed in either group. CONCLUSION: Granisetron is a better prophylactic antiemetic than droperidol or metoclopramide in female patients with a history of motion sickness undergoing major gynaecological surgery. SN - 0832-610X UR - https://www.unboundmedicine.com/medline/citation/9260009/Prevention_of_PONV_with_granisetron_droperidol_and_metoclopramide_in_female_patients_with_history_of_motion_sickness_ L2 - https://dx.doi.org/10.1007/BF03013157 DB - PRIME DP - Unbound Medicine ER -