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Lipids, apolipoprotein-E genotypes and other risk factors of patients with coronary artery disease in Curaçao.
West Indian Med J. 1997 Jun; 46(2):47-52.WI

Abstract

We studied lipids, apolipoprotein-E (apo-epsilon) genotypes and other coronary artery disease (CAD) risk factors of 67 CAD patients (male/female ratio 5) in Curaçao. Compared with 57 controls, male CAD patients had higher cholesterol, triglycerides, LDL-cholesterol, apo-B and decreased HDL-cholesterol and HDL-cholesterol/cholesterol concentrations. Other CAD risk factors were: increased fasting glucose and HbA1c concentrations, decreased creatinine clearance, and increased prevalences of lipoprotein (a) concentration > 500 mg/l, renal disease, hyperhomocysteinaemia, diabetes mellitus type II (DM-II), positive CAD family history and cigarette smoking. Male CAD patients had higher plasma alpha-tocopheroleq. Compared with 29 female controls, female CAD patients had higher fasting plasma glucose and HbA1c concentrations, and prevalence of DM-II. Predicting factors for CAD development in the whole CAD group were: DM-II, cigarette smoking, apo-epsilon 3/epsilon 4 and apo-epsilon 4/epsilon 4 Apo-epsilon 4 was associated with lower HDL- and higher LDL-cholesterol concentrations. There is a need for local studies on improvement of diabetic control, reference values of lipoprotein (a) and homocysteine concentrations, on apolipoprotein (a) phenotypes, causes of hyperhomocysteinaemia, and dietary influences on CAD development in subjects who carry the apo-epsilon 4 allele.

Authors+Show Affiliations

Central Laboratory for Clinical Chemistry, University Hospital Gröningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9260534

Citation

Brouwer, D A., et al. "Lipids, apolipoprotein-E Genotypes and Other Risk Factors of Patients With Coronary Artery Disease in Curaçao." The West Indian Medical Journal, vol. 46, no. 2, 1997, pp. 47-52.
Brouwer DA, Leerink CB, Steward HN, et al. Lipids, apolipoprotein-E genotypes and other risk factors of patients with coronary artery disease in Curaçao. West Indian Med J. 1997;46(2):47-52.
Brouwer, D. A., Leerink, C. B., Steward, H. N., Kroon, T. A., Suverkropp, G. H., Römer, J. W., Volmer, M., & Muskiet, F. A. (1997). Lipids, apolipoprotein-E genotypes and other risk factors of patients with coronary artery disease in Curaçao. The West Indian Medical Journal, 46(2), 47-52.
Brouwer DA, et al. Lipids, apolipoprotein-E Genotypes and Other Risk Factors of Patients With Coronary Artery Disease in Curaçao. West Indian Med J. 1997;46(2):47-52. PubMed PMID: 9260534.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lipids, apolipoprotein-E genotypes and other risk factors of patients with coronary artery disease in Curaçao. AU - Brouwer,D A, AU - Leerink,C B, AU - Steward,H N, AU - Kroon,T A, AU - Suverkropp,G H, AU - Römer,J W, AU - Volmer,M, AU - Muskiet,F A, PY - 1997/6/1/pubmed PY - 1997/6/1/medline PY - 1997/6/1/entrez SP - 47 EP - 52 JF - The West Indian medical journal JO - West Indian Med J VL - 46 IS - 2 N2 - We studied lipids, apolipoprotein-E (apo-epsilon) genotypes and other coronary artery disease (CAD) risk factors of 67 CAD patients (male/female ratio 5) in Curaçao. Compared with 57 controls, male CAD patients had higher cholesterol, triglycerides, LDL-cholesterol, apo-B and decreased HDL-cholesterol and HDL-cholesterol/cholesterol concentrations. Other CAD risk factors were: increased fasting glucose and HbA1c concentrations, decreased creatinine clearance, and increased prevalences of lipoprotein (a) concentration > 500 mg/l, renal disease, hyperhomocysteinaemia, diabetes mellitus type II (DM-II), positive CAD family history and cigarette smoking. Male CAD patients had higher plasma alpha-tocopheroleq. Compared with 29 female controls, female CAD patients had higher fasting plasma glucose and HbA1c concentrations, and prevalence of DM-II. Predicting factors for CAD development in the whole CAD group were: DM-II, cigarette smoking, apo-epsilon 3/epsilon 4 and apo-epsilon 4/epsilon 4 Apo-epsilon 4 was associated with lower HDL- and higher LDL-cholesterol concentrations. There is a need for local studies on improvement of diabetic control, reference values of lipoprotein (a) and homocysteine concentrations, on apolipoprotein (a) phenotypes, causes of hyperhomocysteinaemia, and dietary influences on CAD development in subjects who carry the apo-epsilon 4 allele. SN - 0043-3144 UR - https://www.unboundmedicine.com/medline/citation/9260534/Lipids_apolipoprotein_E_genotypes_and_other_risk_factors_of_patients_with_coronary_artery_disease_in_Curaçao_ DB - PRIME DP - Unbound Medicine ER -