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Quantitative estimation of retinal nerve fiber layer height in glaucoma and the relationship with optic nerve head topography and visual field.
J Glaucoma. 1997 Aug; 6(4):221-30.JG

Abstract

PURPOSE

The authors estimated the retinal nerve fiber layer height (RNFLH) measurements in patients with glaucoma compared with those in age-matched healthy subjects as obtained by the laser scanning tomography and assessed the relationship between RNFLH measurements and optic and visual field status.

METHODS

Parameters of optic nerve head topography and RNFLH were evaluated in 125 eyes of 21 healthy subjects and 104 patients with glaucoma using the Heidelberg Retina Tomograph ([HRT] Heidelberg Engineering GmbH, Heidelberg, Germany) for the entire disc area and for the superior 70 degrees (50 degrees temporal and 20 degrees nasal to the vertical midline) and inferior 70 degrees sectors of the optic disc. The mean deviation of the visual field, as determined by the Humphrey program 24-2 (Humphrey Instruments, Inc., San Leonardo, CA, U.S.A) was calculated in the entire field and in the superior and inferior Bjerrum area.

RESULT

Retinal nerve fiber layer height parameters (mean RNFLH and RNFL cross-sectional area) were decreased significantly in patients with glaucoma compared with healthy individuals. Retinal nerve fiber layer height parameters was correlated strongly with rim volume, rim area, and cup/disc area ratio. Of the various topography measures, retinal nerve fiber layer (RNFL) parameters and cup/disc area ratio showed the strongest correlation with visual field mean deviation in patients with glaucoma.

CONCLUSION

Retinal nerve fiber layer height measures were reduced substantially in patients with glaucoma compared with age-matched healthy subjects. Retinal nerve fiber layer height was correlated strongly with topographic optic disc parameters and visual field changes in patients with glaucoma.

Authors+Show Affiliations

William and Anna Goldberg Glaucoma Service, Wills Eye Hospital, Jefferson Medical College, Philadelphia, Pennsylvania 19107, U.S.A.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9264301

Citation

Eid, T M., et al. "Quantitative Estimation of Retinal Nerve Fiber Layer Height in Glaucoma and the Relationship With Optic Nerve Head Topography and Visual Field." Journal of Glaucoma, vol. 6, no. 4, 1997, pp. 221-30.
Eid TM, Spaeth GL, Katz LJ, et al. Quantitative estimation of retinal nerve fiber layer height in glaucoma and the relationship with optic nerve head topography and visual field. J Glaucoma. 1997;6(4):221-30.
Eid, T. M., Spaeth, G. L., Katz, L. J., Azuara-Blanco, A., Agusburger, J., & Nicholl, J. (1997). Quantitative estimation of retinal nerve fiber layer height in glaucoma and the relationship with optic nerve head topography and visual field. Journal of Glaucoma, 6(4), 221-30.
Eid TM, et al. Quantitative Estimation of Retinal Nerve Fiber Layer Height in Glaucoma and the Relationship With Optic Nerve Head Topography and Visual Field. J Glaucoma. 1997;6(4):221-30. PubMed PMID: 9264301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantitative estimation of retinal nerve fiber layer height in glaucoma and the relationship with optic nerve head topography and visual field. AU - Eid,T M, AU - Spaeth,G L, AU - Katz,L J, AU - Azuara-Blanco,A, AU - Agusburger,J, AU - Nicholl,J, PY - 1997/8/1/pubmed PY - 1997/8/1/medline PY - 1997/8/1/entrez SP - 221 EP - 30 JF - Journal of glaucoma JO - J Glaucoma VL - 6 IS - 4 N2 - PURPOSE: The authors estimated the retinal nerve fiber layer height (RNFLH) measurements in patients with glaucoma compared with those in age-matched healthy subjects as obtained by the laser scanning tomography and assessed the relationship between RNFLH measurements and optic and visual field status. METHODS: Parameters of optic nerve head topography and RNFLH were evaluated in 125 eyes of 21 healthy subjects and 104 patients with glaucoma using the Heidelberg Retina Tomograph ([HRT] Heidelberg Engineering GmbH, Heidelberg, Germany) for the entire disc area and for the superior 70 degrees (50 degrees temporal and 20 degrees nasal to the vertical midline) and inferior 70 degrees sectors of the optic disc. The mean deviation of the visual field, as determined by the Humphrey program 24-2 (Humphrey Instruments, Inc., San Leonardo, CA, U.S.A) was calculated in the entire field and in the superior and inferior Bjerrum area. RESULT: Retinal nerve fiber layer height parameters (mean RNFLH and RNFL cross-sectional area) were decreased significantly in patients with glaucoma compared with healthy individuals. Retinal nerve fiber layer height parameters was correlated strongly with rim volume, rim area, and cup/disc area ratio. Of the various topography measures, retinal nerve fiber layer (RNFL) parameters and cup/disc area ratio showed the strongest correlation with visual field mean deviation in patients with glaucoma. CONCLUSION: Retinal nerve fiber layer height measures were reduced substantially in patients with glaucoma compared with age-matched healthy subjects. Retinal nerve fiber layer height was correlated strongly with topographic optic disc parameters and visual field changes in patients with glaucoma. SN - 1057-0829 UR - https://www.unboundmedicine.com/medline/citation/9264301/Quantitative_estimation_of_retinal_nerve_fiber_layer_height_in_glaucoma_and_the_relationship_with_optic_nerve_head_topography_and_visual_field_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=9264301.ui DB - PRIME DP - Unbound Medicine ER -