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Differences in skin-prick and patch-test reactivity are related to the heterogeneity of atopic eczema in infants.
Allergy 1997; 52(7):755-9A

Abstract

Current data indicate an obvious relation between food allergy and atopic eczema in infants. However, diagnostic methods for food allergy need to be supplemented. The objective was to study the relevance of food patch testing in the detection of food allergy in correlation with oral food challenge and skin prick tests in atopic infants. Infants with atopic eczema (n = 113) aged 2-24 months were studied. Each patient was subjected to double-blind, placebo-controlled, or open cow's milk challenge, and skin prick and patch tests. Polysensitization, as judged from skin test results, was common in patients with atopic eczema (79/113). Cow's milk challenge was positive in 54/113 infants; reactions were immediate in 36/54 and delayed in 18/54. Immediate-type reactions were associated with skin prick test positivity and delayed reactions with patch test positivity. Altogether 26% of the cow's milk-allergic infants were detected by patch testing only. Patch testing improved the accuracy of skin testing in the diagnosis of food allergy in infants with atopic eczema, but it needs to be standardized. Polysensitization appears to be more common than generally believed among infants with atopic eczema.

Authors+Show Affiliations

Department of Dermatology, Tampere University Hospital, Finland.No affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9265992

Citation

Kekki, O M., et al. "Differences in Skin-prick and Patch-test Reactivity Are Related to the Heterogeneity of Atopic Eczema in Infants." Allergy, vol. 52, no. 7, 1997, pp. 755-9.
Kekki OM, Turjanmaa K, Isolauri E. Differences in skin-prick and patch-test reactivity are related to the heterogeneity of atopic eczema in infants. Allergy. 1997;52(7):755-9.
Kekki, O. M., Turjanmaa, K., & Isolauri, E. (1997). Differences in skin-prick and patch-test reactivity are related to the heterogeneity of atopic eczema in infants. Allergy, 52(7), pp. 755-9.
Kekki OM, Turjanmaa K, Isolauri E. Differences in Skin-prick and Patch-test Reactivity Are Related to the Heterogeneity of Atopic Eczema in Infants. Allergy. 1997;52(7):755-9. PubMed PMID: 9265992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in skin-prick and patch-test reactivity are related to the heterogeneity of atopic eczema in infants. AU - Kekki,O M, AU - Turjanmaa,K, AU - Isolauri,E, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 755 EP - 9 JF - Allergy JO - Allergy VL - 52 IS - 7 N2 - Current data indicate an obvious relation between food allergy and atopic eczema in infants. However, diagnostic methods for food allergy need to be supplemented. The objective was to study the relevance of food patch testing in the detection of food allergy in correlation with oral food challenge and skin prick tests in atopic infants. Infants with atopic eczema (n = 113) aged 2-24 months were studied. Each patient was subjected to double-blind, placebo-controlled, or open cow's milk challenge, and skin prick and patch tests. Polysensitization, as judged from skin test results, was common in patients with atopic eczema (79/113). Cow's milk challenge was positive in 54/113 infants; reactions were immediate in 36/54 and delayed in 18/54. Immediate-type reactions were associated with skin prick test positivity and delayed reactions with patch test positivity. Altogether 26% of the cow's milk-allergic infants were detected by patch testing only. Patch testing improved the accuracy of skin testing in the diagnosis of food allergy in infants with atopic eczema, but it needs to be standardized. Polysensitization appears to be more common than generally believed among infants with atopic eczema. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/9265992/Differences_in_skin_prick_and_patch_test_reactivity_are_related_to_the_heterogeneity_of_atopic_eczema_in_infants_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0105-4538&date=1997&volume=52&issue=7&spage=755 DB - PRIME DP - Unbound Medicine ER -