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Effects of oral supplementation of coenzyme Q10 on 31P-NMR detected skeletal muscle energy metabolism in middle-aged post-polio subjects and normal volunteers.
Mol Aspects Med. 1997; 18 Suppl:S291-8.MA

Abstract

The effects of oral supplementation of 100 mg coenzyme Q10 (CoQ10) for 6 months on muscle energy metabolism during exercise and recovery were evaluated in middle-aged post-polio (n = 3) and healthy subjects (n = 4) by the use of phosphorus-31 nuclear magnetic resonance spectroscopy. The metabolic response to isometric plantar flexion at 60% of maximal voluntary contraction force (MVC) for 1.5 min was determined in gastrocnemius muscles before, after 3- (3MO) and 6-month (6MO) of CoQ10 supplementation. The MVC of plantar flexion was unchanged following CoQ10 supplementation. The resting Pi/PCr ratio in gastrocnemius muscles of all subjects decreased after 3MO- and 6MO-CoQ10 (P < 0.05). The post-polio individuals showed a progressive decrease in this ratio, while less pronounced changes were observed in the control subjects. Similarly, the post-polio individuals showed a lower Pi/PCr ratio at the end of 60% MVC in both 3MO- and 6MO-CoQ10, whereas no change in the ratio was observed in the control subjects. A less pronounced decrease in muscle pH was observed at the end of 60% MVC in both 3MO- and 6MO-CoQ10 in the post-polio individuals, but not in the control subjects. No systematic difference in end-exercise ATP was observed between the three phases in both groups. The half-time of recovery for PCr decreased in all subjects after 6MO-CoQ10 supplementation (P < 0.05). The results suggest that CoQ10 supplementation affects muscle energy metabolism in post-polio individuals to a greater extent than in control subjects. The mechanism for this effect is not clear, but may involve an effect of CoQ10 on peripheral circulation in the calf muscles, its action in mitochondrial oxidative phosphorylation and/or its antioxidant potential.

Authors+Show Affiliations

Department of Medical Biochemistry and Genetics, Panum Institute, University of Copenhagen, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9266539

Citation

Mizuno, M, et al. "Effects of Oral Supplementation of Coenzyme Q10 On 31P-NMR Detected Skeletal Muscle Energy Metabolism in Middle-aged Post-polio Subjects and Normal Volunteers." Molecular Aspects of Medicine, vol. 18 Suppl, 1997, pp. S291-8.
Mizuno M, Quistorff B, Theorell H, et al. Effects of oral supplementation of coenzyme Q10 on 31P-NMR detected skeletal muscle energy metabolism in middle-aged post-polio subjects and normal volunteers. Mol Aspects Med. 1997;18 Suppl:S291-8.
Mizuno, M., Quistorff, B., Theorell, H., Theorell, M., & Chance, B. (1997). Effects of oral supplementation of coenzyme Q10 on 31P-NMR detected skeletal muscle energy metabolism in middle-aged post-polio subjects and normal volunteers. Molecular Aspects of Medicine, 18 Suppl, S291-8.
Mizuno M, et al. Effects of Oral Supplementation of Coenzyme Q10 On 31P-NMR Detected Skeletal Muscle Energy Metabolism in Middle-aged Post-polio Subjects and Normal Volunteers. Mol Aspects Med. 1997;18 Suppl:S291-8. PubMed PMID: 9266539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of oral supplementation of coenzyme Q10 on 31P-NMR detected skeletal muscle energy metabolism in middle-aged post-polio subjects and normal volunteers. AU - Mizuno,M, AU - Quistorff,B, AU - Theorell,H, AU - Theorell,M, AU - Chance,B, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - S291 EP - 8 JF - Molecular aspects of medicine JO - Mol. Aspects Med. VL - 18 Suppl N2 - The effects of oral supplementation of 100 mg coenzyme Q10 (CoQ10) for 6 months on muscle energy metabolism during exercise and recovery were evaluated in middle-aged post-polio (n = 3) and healthy subjects (n = 4) by the use of phosphorus-31 nuclear magnetic resonance spectroscopy. The metabolic response to isometric plantar flexion at 60% of maximal voluntary contraction force (MVC) for 1.5 min was determined in gastrocnemius muscles before, after 3- (3MO) and 6-month (6MO) of CoQ10 supplementation. The MVC of plantar flexion was unchanged following CoQ10 supplementation. The resting Pi/PCr ratio in gastrocnemius muscles of all subjects decreased after 3MO- and 6MO-CoQ10 (P < 0.05). The post-polio individuals showed a progressive decrease in this ratio, while less pronounced changes were observed in the control subjects. Similarly, the post-polio individuals showed a lower Pi/PCr ratio at the end of 60% MVC in both 3MO- and 6MO-CoQ10, whereas no change in the ratio was observed in the control subjects. A less pronounced decrease in muscle pH was observed at the end of 60% MVC in both 3MO- and 6MO-CoQ10 in the post-polio individuals, but not in the control subjects. No systematic difference in end-exercise ATP was observed between the three phases in both groups. The half-time of recovery for PCr decreased in all subjects after 6MO-CoQ10 supplementation (P < 0.05). The results suggest that CoQ10 supplementation affects muscle energy metabolism in post-polio individuals to a greater extent than in control subjects. The mechanism for this effect is not clear, but may involve an effect of CoQ10 on peripheral circulation in the calf muscles, its action in mitochondrial oxidative phosphorylation and/or its antioxidant potential. SN - 0098-2997 UR - https://www.unboundmedicine.com/medline/citation/9266539/Effects_of_oral_supplementation_of_coenzyme_Q10_on_31P_NMR_detected_skeletal_muscle_energy_metabolism_in_middle_aged_post_polio_subjects_and_normal_volunteers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0098-2997(97)00001-0 DB - PRIME DP - Unbound Medicine ER -