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Changes in biochemical indicators of iron status during iron repletion and depletion in monkeys.
Ann Nutr Metab. 1997; 41(2):126-36.AN

Abstract

Different modes of iron depletion and repletion were studied in monkeys to understand the sequential changes in and the relative importance of different biochemical indicators of iron status. Six control monkeys were divided into two groups, one was fed an iron-deficient diet (group 1) and the other underwent phlebotomy in addition to receiving an iron-deficient diet (group 2). Previously iron-depleted monkeys were subdivided into 4 groups of 3 animals each. While one group was continued on the iron-deficient diet (group 3), the second group received parenteral iron (group 4), the third group (group 5) received a sufficient-iron-containing diet, and the fourth group was fed 50% of the iron requirement. All indicators of iron status like hemoglobin (Hb), erythrocyte protoporphyrin (EPP), serum transferrin saturation and serum ferritin were monitored periodically, in addition to liver and bone marrow iron. all the indicators except serum ferritin and liver iron showed a decrease in group 2. On the other hand, animals receiving parenteral iron (group 4) showed an increase in all the parameters except serum ferritin. The dietary supplementation produced an increase in Hb and a decrease in EPP only (groups 5 and 6). There was a significant positive correlation between changes in bone marrow iron and Hb concentration depending on the severity of depletion and repletion. Both serum ferritin and liver iron did not respond to changes in dietary iron. Another parameter which responded to repletion was EPP. Serum ferritin and liver iron did not respond to changes in dietary iron or was not sensitive to subclinical iron deficiency. The results indicate that change in Hb is more sensitive to detect the deficiency of iron. It was also observed that different parameters respond variably under different modes of depletion and repletion.

Authors+Show Affiliations

National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania PO, Hyderabad, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9267587

Citation

Sreeramulu, D, et al. "Changes in Biochemical Indicators of Iron Status During Iron Repletion and Depletion in Monkeys." Annals of Nutrition & Metabolism, vol. 41, no. 2, 1997, pp. 126-36.
Sreeramulu D, Nair KM, Qadri SS, et al. Changes in biochemical indicators of iron status during iron repletion and depletion in monkeys. Ann Nutr Metab. 1997;41(2):126-36.
Sreeramulu, D., Nair, K. M., Qadri, S. S., Rao, K. V., & Sivakumar, B. (1997). Changes in biochemical indicators of iron status during iron repletion and depletion in monkeys. Annals of Nutrition & Metabolism, 41(2), 126-36.
Sreeramulu D, et al. Changes in Biochemical Indicators of Iron Status During Iron Repletion and Depletion in Monkeys. Ann Nutr Metab. 1997;41(2):126-36. PubMed PMID: 9267587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in biochemical indicators of iron status during iron repletion and depletion in monkeys. AU - Sreeramulu,D, AU - Nair,K M, AU - Qadri,S S, AU - Rao,K V, AU - Sivakumar,B, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 126 EP - 36 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 41 IS - 2 N2 - Different modes of iron depletion and repletion were studied in monkeys to understand the sequential changes in and the relative importance of different biochemical indicators of iron status. Six control monkeys were divided into two groups, one was fed an iron-deficient diet (group 1) and the other underwent phlebotomy in addition to receiving an iron-deficient diet (group 2). Previously iron-depleted monkeys were subdivided into 4 groups of 3 animals each. While one group was continued on the iron-deficient diet (group 3), the second group received parenteral iron (group 4), the third group (group 5) received a sufficient-iron-containing diet, and the fourth group was fed 50% of the iron requirement. All indicators of iron status like hemoglobin (Hb), erythrocyte protoporphyrin (EPP), serum transferrin saturation and serum ferritin were monitored periodically, in addition to liver and bone marrow iron. all the indicators except serum ferritin and liver iron showed a decrease in group 2. On the other hand, animals receiving parenteral iron (group 4) showed an increase in all the parameters except serum ferritin. The dietary supplementation produced an increase in Hb and a decrease in EPP only (groups 5 and 6). There was a significant positive correlation between changes in bone marrow iron and Hb concentration depending on the severity of depletion and repletion. Both serum ferritin and liver iron did not respond to changes in dietary iron. Another parameter which responded to repletion was EPP. Serum ferritin and liver iron did not respond to changes in dietary iron or was not sensitive to subclinical iron deficiency. The results indicate that change in Hb is more sensitive to detect the deficiency of iron. It was also observed that different parameters respond variably under different modes of depletion and repletion. SN - 0250-6807 UR - https://www.unboundmedicine.com/medline/citation/9267587/Changes_in_biochemical_indicators_of_iron_status_during_iron_repletion_and_depletion_in_monkeys_ L2 - https://www.karger.com?DOI=10.1159/000177988 DB - PRIME DP - Unbound Medicine ER -