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Anemia following renal transplantation: erythropoietin response and iron deficiency.
Clin Transplant. 1997 Aug; 11(4):313-5.CT

Abstract

To define the etiology of anemia post-renal transplantation, we assessed hematologic parameters and EPO levels in 38 anemic and 16 non-anemic control renal transplant recipients (RTRs) with varying degrees of allograft function at periods > 3 months post-transplantation. Significant differences between the two groups were found for serum creatinine (Cr) 291.7 +/- 26.5 vs. 203.3 +/- 26.5 mumol/l, p < 0.01; iron 9.3 +/- 0.92 vs. 13.6 +/- 1.7 mumol/l, p < 0.05; and ferritin 345.5 +/- 90.8 vs. 91.1 +/- 18.5 micrograms/l, p < 0.01. Serum EPO levels were inappropriately low in anemic patients with no significant correlation between EPO and Cr or hematocrit (Hct) levels. Serum iron was the only predictive factor for anemia on regression analysis (p < 0.05). Ferritin levels did not correlate with serum iron or Hct, and may be falsely elevated in iron deficient RTRs. Iron deficiency, poor renal function and inappropriately low EPO levels are major contributors to the 12% of our outpatient renal transplant population who are anemic.

Authors+Show Affiliations

Department of Medicine, State University of New York Health Science Center at Brooklyn 11203, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9267720

Citation

Miles, A M., et al. "Anemia Following Renal Transplantation: Erythropoietin Response and Iron Deficiency." Clinical Transplantation, vol. 11, no. 4, 1997, pp. 313-5.
Miles AM, Markell MS, Daskalakis P, et al. Anemia following renal transplantation: erythropoietin response and iron deficiency. Clin Transplant. 1997;11(4):313-5.
Miles, A. M., Markell, M. S., Daskalakis, P., Sumrani, N. B., Hong, J., Sommer, B. G., & Friedman, E. A. (1997). Anemia following renal transplantation: erythropoietin response and iron deficiency. Clinical Transplantation, 11(4), 313-5.
Miles AM, et al. Anemia Following Renal Transplantation: Erythropoietin Response and Iron Deficiency. Clin Transplant. 1997;11(4):313-5. PubMed PMID: 9267720.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anemia following renal transplantation: erythropoietin response and iron deficiency. AU - Miles,A M, AU - Markell,M S, AU - Daskalakis,P, AU - Sumrani,N B, AU - Hong,J, AU - Sommer,B G, AU - Friedman,E A, PY - 1997/8/1/pubmed PY - 1997/8/1/medline PY - 1997/8/1/entrez SP - 313 EP - 5 JF - Clinical transplantation JO - Clin Transplant VL - 11 IS - 4 N2 - To define the etiology of anemia post-renal transplantation, we assessed hematologic parameters and EPO levels in 38 anemic and 16 non-anemic control renal transplant recipients (RTRs) with varying degrees of allograft function at periods > 3 months post-transplantation. Significant differences between the two groups were found for serum creatinine (Cr) 291.7 +/- 26.5 vs. 203.3 +/- 26.5 mumol/l, p < 0.01; iron 9.3 +/- 0.92 vs. 13.6 +/- 1.7 mumol/l, p < 0.05; and ferritin 345.5 +/- 90.8 vs. 91.1 +/- 18.5 micrograms/l, p < 0.01. Serum EPO levels were inappropriately low in anemic patients with no significant correlation between EPO and Cr or hematocrit (Hct) levels. Serum iron was the only predictive factor for anemia on regression analysis (p < 0.05). Ferritin levels did not correlate with serum iron or Hct, and may be falsely elevated in iron deficient RTRs. Iron deficiency, poor renal function and inappropriately low EPO levels are major contributors to the 12% of our outpatient renal transplant population who are anemic. SN - 0902-0063 UR - https://www.unboundmedicine.com/medline/citation/9267720/Anemia_following_renal_transplantation:_erythropoietin_response_and_iron_deficiency_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=9267720.ui DB - PRIME DP - Unbound Medicine ER -