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Seasonal variation in low density lipoprotein oxidation and antioxidant status.

Abstract

Accumulating evidence indicates that oxidative modification of low-density lipoproteins is atherogenic and that antioxidants may play a role in protection of LDL against oxidation. Several studies have reported a seasonal fluctuation in antioxidant levels, but to date nothing is known about seasonal fluctuations in parameters of oxidizability. We collected blood from 10 volunteers at four different periods over one year (February, May, September and December), and measured the amount of plasma lipids, plasma antioxidants, lipid and fatty acid composition of the LDL particle, LDL antioxidant content, LDL particle size and oxidation parameters (lag time and propagation rate). No seasonal fluctuation for lag time and propagation rate of copper ion-induced LDL oxidation was found. Small seasonal fluctuations were observed for some determinants of LDL oxidation, e.g. plasma and LDL vitamin E and LDL particle size, and for plasma lipids, plasma and LDL lutein and LDL beta-carotene. Fatty acid composition of LDL did not change during the year. The main determinant of oxidation susceptibility was the fatty acid composition of LDL. We conclude that LDL oxidation parameters do not change over the year.

Authors+Show Affiliations

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Department of Consumers Research and Epidemiology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands.

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Source

Free radical research 27:1 1997 Jul pg 89-96

MeSH

Adult
Antioxidants
Cholesterol
Cholesterol, LDL
Fatty Acids
Female
Humans
Lipids
Lipoproteins, LDL
Lutein
Male
Middle Aged
Oxidation-Reduction
Seasons
Vitamin E

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9269583

Citation

Van de Vijver, L P., et al. "Seasonal Variation in Low Density Lipoprotein Oxidation and Antioxidant Status." Free Radical Research, vol. 27, no. 1, 1997, pp. 89-96.
Van de Vijver LP, Van Duyvenvoorde W, Buytenhek R, et al. Seasonal variation in low density lipoprotein oxidation and antioxidant status. Free Radic Res. 1997;27(1):89-96.
Van de Vijver, L. P., Van Duyvenvoorde, W., Buytenhek, R., Van der Laarse, A., Kardinaal, A. F., Van Den Berg, H., & Princen, H. M. (1997). Seasonal variation in low density lipoprotein oxidation and antioxidant status. Free Radical Research, 27(1), pp. 89-96.
Van de Vijver LP, et al. Seasonal Variation in Low Density Lipoprotein Oxidation and Antioxidant Status. Free Radic Res. 1997;27(1):89-96. PubMed PMID: 9269583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seasonal variation in low density lipoprotein oxidation and antioxidant status. AU - Van de Vijver,L P, AU - Van Duyvenvoorde,W, AU - Buytenhek,R, AU - Van der Laarse,A, AU - Kardinaal,A F, AU - Van Den Berg,H, AU - Princen,H M, PY - 1997/7/1/pubmed PY - 1997/7/1/medline PY - 1997/7/1/entrez SP - 89 EP - 96 JF - Free radical research JO - Free Radic. Res. VL - 27 IS - 1 N2 - Accumulating evidence indicates that oxidative modification of low-density lipoproteins is atherogenic and that antioxidants may play a role in protection of LDL against oxidation. Several studies have reported a seasonal fluctuation in antioxidant levels, but to date nothing is known about seasonal fluctuations in parameters of oxidizability. We collected blood from 10 volunteers at four different periods over one year (February, May, September and December), and measured the amount of plasma lipids, plasma antioxidants, lipid and fatty acid composition of the LDL particle, LDL antioxidant content, LDL particle size and oxidation parameters (lag time and propagation rate). No seasonal fluctuation for lag time and propagation rate of copper ion-induced LDL oxidation was found. Small seasonal fluctuations were observed for some determinants of LDL oxidation, e.g. plasma and LDL vitamin E and LDL particle size, and for plasma lipids, plasma and LDL lutein and LDL beta-carotene. Fatty acid composition of LDL did not change during the year. The main determinant of oxidation susceptibility was the fatty acid composition of LDL. We conclude that LDL oxidation parameters do not change over the year. SN - 1071-5762 UR - https://www.unboundmedicine.com/medline/citation/9269583/Seasonal_variation_in_low_density_lipoprotein_oxidation_and_antioxidant_status_ L2 - https://medlineplus.gov/antioxidants.html DB - PRIME DP - Unbound Medicine ER -