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Immunosuppression induced by acute solar-simulated ultraviolet exposure in humans: prevention by a sunscreen with a sun protection factor of 15 and high UVA protection.
J Am Acad Dermatol. 1997 Aug; 37(2 Pt 1):187-94.JA

Abstract

BACKGROUND

Cutaneous exposure to UVB radiation impairs the induction of contact hypersensitivity (CHS). Variable results have been found among studies examining the use of sunscreens to prevent UV-induced immunosuppression.

OBJECTIVE

Our purpose was to determine whether solar-simulated exposure of human skin resulted in an impairment of CHS responses and whether the preapplication of an intermediate sun protection factor (SPF) sunscreen could prevent this locally UV-induced immunosuppression.

METHODS

Irritant and CHS responses to dinitrochlorobenzene (DNCB) were randomly assessed in 160 human volunteers with or without UV exposure and with or without prior application of an SPF 15 sunscreen with high UVA protection. DNCB sensitization was performed 3 days after acute UV irradiation corresponding to 3 minimal erythema doses.

RESULTS

After solar-simulated UV exposure, the percentage of positive responses to DNCB sensitization dropped from 95% to 50% (p = 0.003). Prior application of the sunscreen formulation did not modify the percentage of positive responses (90%) and maintained the immunization rate at 85% among volunteers exposed to UV.

CONCLUSION

A localized sunburn can impair the afferent arm of CHS reactions in humans. The use of intermediate SPF sunscreens with high UVA protection adequately protects from the suppression of CHS responses that occurs after acute solar-simulated UV exposure.

Authors+Show Affiliations

Laboratory of Drug Toxicology, University of Montpellier, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9270502

Citation

Serre, I, et al. "Immunosuppression Induced By Acute Solar-simulated Ultraviolet Exposure in Humans: Prevention By a Sunscreen With a Sun Protection Factor of 15 and High UVA Protection." Journal of the American Academy of Dermatology, vol. 37, no. 2 Pt 1, 1997, pp. 187-94.
Serre I, Cano JP, Picot MC, et al. Immunosuppression induced by acute solar-simulated ultraviolet exposure in humans: prevention by a sunscreen with a sun protection factor of 15 and high UVA protection. J Am Acad Dermatol. 1997;37(2 Pt 1):187-94.
Serre, I., Cano, J. P., Picot, M. C., Meynadier, J., & Meunier, L. (1997). Immunosuppression induced by acute solar-simulated ultraviolet exposure in humans: prevention by a sunscreen with a sun protection factor of 15 and high UVA protection. Journal of the American Academy of Dermatology, 37(2 Pt 1), 187-94.
Serre I, et al. Immunosuppression Induced By Acute Solar-simulated Ultraviolet Exposure in Humans: Prevention By a Sunscreen With a Sun Protection Factor of 15 and High UVA Protection. J Am Acad Dermatol. 1997;37(2 Pt 1):187-94. PubMed PMID: 9270502.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunosuppression induced by acute solar-simulated ultraviolet exposure in humans: prevention by a sunscreen with a sun protection factor of 15 and high UVA protection. AU - Serre,I, AU - Cano,J P, AU - Picot,M C, AU - Meynadier,J, AU - Meunier,L, PY - 1997/8/1/pubmed PY - 1997/8/1/medline PY - 1997/8/1/entrez SP - 187 EP - 94 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 37 IS - 2 Pt 1 N2 - BACKGROUND: Cutaneous exposure to UVB radiation impairs the induction of contact hypersensitivity (CHS). Variable results have been found among studies examining the use of sunscreens to prevent UV-induced immunosuppression. OBJECTIVE: Our purpose was to determine whether solar-simulated exposure of human skin resulted in an impairment of CHS responses and whether the preapplication of an intermediate sun protection factor (SPF) sunscreen could prevent this locally UV-induced immunosuppression. METHODS: Irritant and CHS responses to dinitrochlorobenzene (DNCB) were randomly assessed in 160 human volunteers with or without UV exposure and with or without prior application of an SPF 15 sunscreen with high UVA protection. DNCB sensitization was performed 3 days after acute UV irradiation corresponding to 3 minimal erythema doses. RESULTS: After solar-simulated UV exposure, the percentage of positive responses to DNCB sensitization dropped from 95% to 50% (p = 0.003). Prior application of the sunscreen formulation did not modify the percentage of positive responses (90%) and maintained the immunization rate at 85% among volunteers exposed to UV. CONCLUSION: A localized sunburn can impair the afferent arm of CHS reactions in humans. The use of intermediate SPF sunscreens with high UVA protection adequately protects from the suppression of CHS responses that occurs after acute solar-simulated UV exposure. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/9270502/Immunosuppression_induced_by_acute_solar_simulated_ultraviolet_exposure_in_humans:_prevention_by_a_sunscreen_with_a_sun_protection_factor_of_15_and_high_UVA_protection_ DB - PRIME DP - Unbound Medicine ER -