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Moderate maternal alcohol consumption and risk of spontaneous abortion.
Epidemiology 1997; 8(5):509-14E

Abstract

Maternal alcoholism is known to have adverse effects on reproduction and fetal development, but the effects of moderate consumption remain controversial. In a previous case-control study, we found a doubled risk of spontaneous abortion with an average consumption of seven or more drinks per week during the first trimester. To confirm this finding while avoiding potential biases from the case-control design, we examined moderate alcohol consumption in a prospective cohort study of over 5,000 pregnant women. An interview in the first trimester asked about alcohol consumption during the week before interview ("during the first trimester") and before pregnancy. We found an increased risk of spontaneous abortion in women who drank more than three drinks per week during the first trimester, with an adjusted odds ratio (OR) of 2.3 [95% confidence interval (CI) = 1.1-4.5]. The increased risk associated with this moderate alcohol consumption may be higher in first than in second trimester abortions, and it is even higher in the first 10 weeks (OR = 3.8; 95% CI = 1.7-8.7), based on small numbers. Consumption of alcohol before pregnancy was not strongly associated with spontaneous abortion.

Authors+Show Affiliations

Reproductive Epidemiology Section, Department of Health Services, Berkeley, CA 94704, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9270952

Citation

Windham, G C., et al. "Moderate Maternal Alcohol Consumption and Risk of Spontaneous Abortion." Epidemiology (Cambridge, Mass.), vol. 8, no. 5, 1997, pp. 509-14.
Windham GC, Von Behren J, Fenster L, et al. Moderate maternal alcohol consumption and risk of spontaneous abortion. Epidemiology. 1997;8(5):509-14.
Windham, G. C., Von Behren, J., Fenster, L., Schaefer, C., & Swan, S. H. (1997). Moderate maternal alcohol consumption and risk of spontaneous abortion. Epidemiology (Cambridge, Mass.), 8(5), pp. 509-14.
Windham GC, et al. Moderate Maternal Alcohol Consumption and Risk of Spontaneous Abortion. Epidemiology. 1997;8(5):509-14. PubMed PMID: 9270952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate maternal alcohol consumption and risk of spontaneous abortion. AU - Windham,G C, AU - Von Behren,J, AU - Fenster,L, AU - Schaefer,C, AU - Swan,S H, PY - 1997/9/1/pubmed PY - 1997/9/1/medline PY - 1997/9/1/entrez SP - 509 EP - 14 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 8 IS - 5 N2 - Maternal alcoholism is known to have adverse effects on reproduction and fetal development, but the effects of moderate consumption remain controversial. In a previous case-control study, we found a doubled risk of spontaneous abortion with an average consumption of seven or more drinks per week during the first trimester. To confirm this finding while avoiding potential biases from the case-control design, we examined moderate alcohol consumption in a prospective cohort study of over 5,000 pregnant women. An interview in the first trimester asked about alcohol consumption during the week before interview ("during the first trimester") and before pregnancy. We found an increased risk of spontaneous abortion in women who drank more than three drinks per week during the first trimester, with an adjusted odds ratio (OR) of 2.3 [95% confidence interval (CI) = 1.1-4.5]. The increased risk associated with this moderate alcohol consumption may be higher in first than in second trimester abortions, and it is even higher in the first 10 weeks (OR = 3.8; 95% CI = 1.7-8.7), based on small numbers. Consumption of alcohol before pregnancy was not strongly associated with spontaneous abortion. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/9270952/Moderate_maternal_alcohol_consumption_and_risk_of_spontaneous_abortion_ L2 - http://dx.doi.org/10.1097/00001648-199709000-00007 DB - PRIME DP - Unbound Medicine ER -