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Serological responses to infection with B. pertussis.
Dev Biol Stand. 1997; 89:213-20.DB

Abstract

The results of serological assays performed during the Italian controlled efficacy trial of two acellular vaccines and one whole-cell vaccine against pertussis are described and discussed. We examined 312 episodes of suspected pertussis disease confirmed by B. pertussis isolation, and 2862 episodes without any evidence of B. pertussis or B. parapertussis infection. Higher mean log ELISA titres for IgG to pertussis toxin (PT) were found in the acute-phase serum specimens of those children vaccinated with the acellular pertussis vaccines and particularly in the SmithKline Beecham DTaP vaccine group. These apparently anamnestic responses were responsible for the observed differences in ELISA diagnostic sensitivity exhibited by IgG to PT and by IgG to filamentous haemagglutinin (FHA). We observed minimal IgA responses to PT but vigorous IgA responses to FHA in the convalescent-phase serum specimens for the acellular pertussis vaccine groups, which contributed to the sensitivity of the serological series of assays for diagnostic purposes.

Authors+Show Affiliations

Università degli Studi di Palermo-Dipartimento di Igiene e Microbiologia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9272353

Citation

Giammanco, A, et al. "Serological Responses to Infection With B. Pertussis." Developments in Biological Standardization, vol. 89, 1997, pp. 213-20.
Giammanco A, Taormina S, Genovese M, et al. Serological responses to infection with B. pertussis. Dev Biol Stand. 1997;89:213-20.
Giammanco, A., Taormina, S., Genovese, M., Mangiaracina, G., Giammanco, G., & Chiarini, A. (1997). Serological responses to infection with B. pertussis. Developments in Biological Standardization, 89, 213-20.
Giammanco A, et al. Serological Responses to Infection With B. Pertussis. Dev Biol Stand. 1997;89:213-20. PubMed PMID: 9272353.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serological responses to infection with B. pertussis. AU - Giammanco,A, AU - Taormina,S, AU - Genovese,M, AU - Mangiaracina,G, AU - Giammanco,G, AU - Chiarini,A, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 213 EP - 20 JF - Developments in biological standardization JO - Dev Biol Stand VL - 89 N2 - The results of serological assays performed during the Italian controlled efficacy trial of two acellular vaccines and one whole-cell vaccine against pertussis are described and discussed. We examined 312 episodes of suspected pertussis disease confirmed by B. pertussis isolation, and 2862 episodes without any evidence of B. pertussis or B. parapertussis infection. Higher mean log ELISA titres for IgG to pertussis toxin (PT) were found in the acute-phase serum specimens of those children vaccinated with the acellular pertussis vaccines and particularly in the SmithKline Beecham DTaP vaccine group. These apparently anamnestic responses were responsible for the observed differences in ELISA diagnostic sensitivity exhibited by IgG to PT and by IgG to filamentous haemagglutinin (FHA). We observed minimal IgA responses to PT but vigorous IgA responses to FHA in the convalescent-phase serum specimens for the acellular pertussis vaccine groups, which contributed to the sensitivity of the serological series of assays for diagnostic purposes. SN - 0301-5149 UR - https://www.unboundmedicine.com/medline/citation/9272353/Serological_responses_to_infection_with_B__pertussis_ L2 - https://medlineplus.gov/tetanusdiphtheriaandpertussisvaccines.html DB - PRIME DP - Unbound Medicine ER -