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Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome.
Gynecol Endocrinol. 1997 Aug; 11(4):251-7.GE

Abstract

Forty-four hirsute patients with polycystic ovary syndrome were randomly treated with finasteride (5 mg daily) or flutamide (250 mg twice daily) for 6 consecutive months. Hirsutism was evaluated before and after therapy with the Ferriman-Gallwey score and with measurement of hair diameter (micron). The hairs were taken from four different body areas: the face, abdomen, thighs and forearm. The measurement was carried out with a micrometer applied to the optical microscope. Mean plasma concentrations of luteinizing hormone, follicle-stimulating hormone, 17 alpha-hydroxyprogesterone, androstenedione, testosterone, free testosterone, dehydroepiandrosterone sulfate, insulin, and sex hormone binding globulin were determined before and after therapy. Hematochemical examinations and side-effects were controlled after the treatment. After 6-months' therapy, both antiandrogens significantly reduced the Ferriman-Gallwey score and hair diameter in all the body areas. Finasteride reduced the Ferriman-Gallwey score by 25% and hair diameter by 16-25%; flutamide reduced the score by 20% and hair diameter by 15.3-22%. Abdominal hairs were more sensitive to both drugs. Flutamide induced a significant drop in total testosterone and dehydroepiandrosterone sulfate. No important side-effect or change in the hematochemical parameters was observed. Our data demonstrate that finasteride and flutamide are effective in the treatment of hirsutism in patients with polycystic ovary syndrome.

Authors+Show Affiliations

Department of Gynecologic Endocrinology, University of Brescia, Italy.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9272421

Citation

Falsetti, L, et al. "Treatment of Hirsutism By Finasteride and Flutamide in Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 11, no. 4, 1997, pp. 251-7.
Falsetti L, De Fusco D, Eleftheriou G, et al. Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome. Gynecol Endocrinol. 1997;11(4):251-7.
Falsetti, L., De Fusco, D., Eleftheriou, G., & Rosina, B. (1997). Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 11(4), 251-7.
Falsetti L, et al. Treatment of Hirsutism By Finasteride and Flutamide in Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 1997;11(4):251-7. PubMed PMID: 9272421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of hirsutism by finasteride and flutamide in women with polycystic ovary syndrome. AU - Falsetti,L, AU - De Fusco,D, AU - Eleftheriou,G, AU - Rosina,B, PY - 1997/8/1/pubmed PY - 1997/8/1/medline PY - 1997/8/1/entrez SP - 251 EP - 7 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 11 IS - 4 N2 - Forty-four hirsute patients with polycystic ovary syndrome were randomly treated with finasteride (5 mg daily) or flutamide (250 mg twice daily) for 6 consecutive months. Hirsutism was evaluated before and after therapy with the Ferriman-Gallwey score and with measurement of hair diameter (micron). The hairs were taken from four different body areas: the face, abdomen, thighs and forearm. The measurement was carried out with a micrometer applied to the optical microscope. Mean plasma concentrations of luteinizing hormone, follicle-stimulating hormone, 17 alpha-hydroxyprogesterone, androstenedione, testosterone, free testosterone, dehydroepiandrosterone sulfate, insulin, and sex hormone binding globulin were determined before and after therapy. Hematochemical examinations and side-effects were controlled after the treatment. After 6-months' therapy, both antiandrogens significantly reduced the Ferriman-Gallwey score and hair diameter in all the body areas. Finasteride reduced the Ferriman-Gallwey score by 25% and hair diameter by 16-25%; flutamide reduced the score by 20% and hair diameter by 15.3-22%. Abdominal hairs were more sensitive to both drugs. Flutamide induced a significant drop in total testosterone and dehydroepiandrosterone sulfate. No important side-effect or change in the hematochemical parameters was observed. Our data demonstrate that finasteride and flutamide are effective in the treatment of hirsutism in patients with polycystic ovary syndrome. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/9272421/Treatment_of_hirsutism_by_finasteride_and_flutamide_in_women_with_polycystic_ovary_syndrome_ L2 - https://www.tandfonline.com/doi/full/10.3109/09513599709152542 DB - PRIME DP - Unbound Medicine ER -