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Role of gonadal steroids in determining sexual differences in expression of Fos-related antigens in tyrosine hydroxylase-immunoreactive neurons in subdivisions of the hypothalamic arcuate nucleus.
Endocrinology. 1997 Sep; 138(9):3804-10.E

Abstract

Dual immunohistochemistry was employed to examine the role of gonadal steroids in determining sexual differences in the expression of Fos and its related antigens (FRA) in tuberoinfundibular dopaminergic (TIDA) neurons located in the dorsomedial (DM-) and ventrolateral (VL-) subdivisions of the arcuate nucleus (ARC). In the DM-ARC, there was no sexual difference in the number of tyrosine hydroxylase (TH)-immunoreactive (-IR) perikarya, but the number of these containing FRA-IR was greater in females than in males in all but the most caudal region. In the VL-ARC, there were more TH-IR perikarya in males than in females, but there was no sexual difference in the numbers of those containing FRA-IR throughout the entire rostrocaudal extent of this nucleus. Ovariectomy decreased the number of TH-IR perikarya containing FRA-IR in the DM-ARC, but not in the VL-ARC, whereas orchidectomy increased the number of TH-IR perikayra containing FRA-IR in both the DM-ARC and VL-ARC. These gonadectomy-induced effects were reversed by estrogen and testosterone, respectively. These results reveal gonadal steroid-dependent sexual differences in the regulation of immediate early gene expression in anatomically discrete subpopulations of TIDA neurons. In females, estrogen stimulates FRA expression in TIDA neurons in the DM-ARC, whereas in males, testosterone inhibits FRA expression in TIDA neurons in both the DM-ARC and the VL-ARC.

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Authors+Show Affiliations

Cheung S
Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824-1317, USA. cheungs@pilot.msu.edu
Will YM
No affiliation info available
Hentschel K
No affiliation info available
Moore KE
No affiliation info available
Lookingland KJ
No affiliation info available

MeSH

AnimalsArcuate Nucleus of HypothalamusEstradiolEstrogensFemaleGene ExpressionGenes, fosImmunohistochemistryMaleNeuronsOrchiectomyOvariectomyProto-Oncogene Proteins c-fosRatsSex CharacteristicsTestosteroneTyrosine 3-Monooxygenase

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

9275068

Citation

Cheung, S, et al. "Role of Gonadal Steroids in Determining Sexual Differences in Expression of Fos-related Antigens in Tyrosine Hydroxylase-immunoreactive Neurons in Subdivisions of the Hypothalamic Arcuate Nucleus." Endocrinology, vol. 138, no. 9, 1997, pp. 3804-10.
Cheung S, Will YM, Hentschel K, et al. Role of gonadal steroids in determining sexual differences in expression of Fos-related antigens in tyrosine hydroxylase-immunoreactive neurons in subdivisions of the hypothalamic arcuate nucleus. Endocrinology. 1997;138(9):3804-10.
Cheung, S., Will, Y. M., Hentschel, K., Moore, K. E., & Lookingland, K. J. (1997). Role of gonadal steroids in determining sexual differences in expression of Fos-related antigens in tyrosine hydroxylase-immunoreactive neurons in subdivisions of the hypothalamic arcuate nucleus. Endocrinology, 138(9), 3804-10.
Cheung S, et al. Role of Gonadal Steroids in Determining Sexual Differences in Expression of Fos-related Antigens in Tyrosine Hydroxylase-immunoreactive Neurons in Subdivisions of the Hypothalamic Arcuate Nucleus. Endocrinology. 1997;138(9):3804-10. PubMed PMID: 9275068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of gonadal steroids in determining sexual differences in expression of Fos-related antigens in tyrosine hydroxylase-immunoreactive neurons in subdivisions of the hypothalamic arcuate nucleus. AU - Cheung,S, AU - Will,Y M, AU - Hentschel,K, AU - Moore,K E, AU - Lookingland,K J, PY - 1997/9/1/pubmed PY - 1997/9/1/medline PY - 1997/9/1/entrez SP - 3804 EP - 10 JF - Endocrinology JO - Endocrinology VL - 138 IS - 9 N2 - Dual immunohistochemistry was employed to examine the role of gonadal steroids in determining sexual differences in the expression of Fos and its related antigens (FRA) in tuberoinfundibular dopaminergic (TIDA) neurons located in the dorsomedial (DM-) and ventrolateral (VL-) subdivisions of the arcuate nucleus (ARC). In the DM-ARC, there was no sexual difference in the number of tyrosine hydroxylase (TH)-immunoreactive (-IR) perikarya, but the number of these containing FRA-IR was greater in females than in males in all but the most caudal region. In the VL-ARC, there were more TH-IR perikarya in males than in females, but there was no sexual difference in the numbers of those containing FRA-IR throughout the entire rostrocaudal extent of this nucleus. Ovariectomy decreased the number of TH-IR perikarya containing FRA-IR in the DM-ARC, but not in the VL-ARC, whereas orchidectomy increased the number of TH-IR perikayra containing FRA-IR in both the DM-ARC and VL-ARC. These gonadectomy-induced effects were reversed by estrogen and testosterone, respectively. These results reveal gonadal steroid-dependent sexual differences in the regulation of immediate early gene expression in anatomically discrete subpopulations of TIDA neurons. In females, estrogen stimulates FRA expression in TIDA neurons in the DM-ARC, whereas in males, testosterone inhibits FRA expression in TIDA neurons in both the DM-ARC and the VL-ARC. SN - 0013-7227 UR - https://www.unboundmedicine.com/medline/citation/9275068/Role_of_gonadal_steroids_in_determining_sexual_differences_in_expression_of_Fos_related_antigens_in_tyrosine_hydroxylase_immunoreactive_neurons_in_subdivisions_of_the_hypothalamic_arcuate_nucleus_ L2 - https://academic.oup.com/endo/article-lookup/doi/10.1210/endo.138.9.5411 DB - PRIME DP - Unbound Medicine ER -